Hnf1a ELISA Kit for Mouse(Mus musculus) | EIAab.comHnf1a ELISA Kit for Mouse(Mus musculus)

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Hnf1a (Gene name),

Hepatocyte nuclear factor 1-alpha (Protein name ), HNF1A_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Hnf1a(Hnf-1;Hnf-1a;Tcf1);

Protein name:

Hepatocyte nuclear factor 1-alpha(HNF-1-alpha;HNF-1A);

Alternative:

Transcription factor 1(TCF-1);Liver-specific transcription factor LF-B1(LFB1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds DNA as a dimer. Interacts with PCBD1. Heterotetramer with PCBD1; formed by a dimer of dimers.

Function:

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

628

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

628:

SNGHSHLLPS | NHSVIETFIS | TQMASSSQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P22361

STRING:

10090.ENSMUSP00000031535

Pfam:

PF04814

SMR:

P22361

KEGG:

mmu:21405

UniGene:

Mm.332607

Uniprot:

P22361

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ELISA Kit for Mouse HNF-1-alpha

Cat.:

E15024r

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Manual:

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96T

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ELISA Kit for Mouse HNF-1-alpha

Cat.:

E15024h

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96T

ELISA Kit for Mouse HNF-1-alpha

Cat.:

E15024m

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96T

ELISA Kit for Mouse HNF-1-alpha

Cat.:

E15024c

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96T

CLIA Kit for Mouse HNF-1-alpha

Cat.:

U15024r

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96T

CLIA Kit for Mouse HNF-1-alpha

Cat.:

U15024h

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96T

CLIA Kit for Mouse HNF-1-alpha

Cat.:

U15024c

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96T

CLIA Kit for Mouse HNF-1-alpha

Cat.:

U15024m

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Packing:

96T

Polyclonal Antibody for Mouse HNF-1-alpha

Cat.:

P15024Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse HNF-1-alpha

Cat.:

P15024Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse HNF-1-alpha

Cat.:

P15024Rb-m

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40ug/0.2ml

Monoclonal Antibody for Mouse HNF-1-alpha

Protein for Mouse HNF-1-alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1."
Kuo C.J. , Conley P.B. , Hsieh C.L. , Francke U. , Crabtree G.R.
Proc. Natl. Acad. Sci. U.S.A.87:9838-9842(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1)."
Bach I. , Pontoglio M. , Yaniv M.
Nucleic Acids Res.20:4199-4204(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE STRUCTURE
4.

"Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse."
Lee Y.H. , Sauer B. , Gonzalez F.J.
Mol. Cell. Biol.18:3059-3068(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
5.

"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H. , Ye M. , Dong J. , Han G. , Jiang X. , Wu R. , Zou H.
J. Proteome Res.7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
6.

"Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver."
Servitja J.M. , Pignatelli M. , Maestro M.A. , Cardalda C. , Boj S.F. , Lozano J. , Blanco E. , Lafuente A. , McCarthy M.I. , Sumoy L. , Guigo R. , Ferrer J.
Mol. Cell. Biol.29:2945-2959(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"High-resolution structure of the HNF-1alpha dimerization domain."
Rose R.B. , Endrizzi J.A. , Cronk J.D. , Holton J. , Alber T.
Biochemistry39:15062-15070(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.0 ANGSTROMS) OF 1-32;SUBUNIT
8.

"Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha."
Rose R.B. , Bayle J.H. , Endrizzi J.A. , Cronk J.D. , Crabtree G.R. , Alber T.
Nat. Struct. Biol.7:744-748(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 1-32 IN COMPLEX WITH PCBD1;SUBUNIT;FUNCTION
9.

"The dimerization domain of HNF-1alpha: structure and plasticity of an intertwined four-helix bundle with application to diabetes mellitus."
Narayana N. , Hua Q. , Weiss M.A.
J. Mol. Biol.310:635-658(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 2-32;SUBUNIT

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