Gene name:
Hspa8 (Hsc70;Hsc73) ;
Protein name:
Heat shock cognate 71 kDa protein ;
Alternative:
Heat shock 70 kDa protein 8 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 and BAG1. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation (By similarity). Interacts with DNAJC7.
Function:
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone.
Subcellular Location:
Cytoplasm
Melanosome
Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
Protein Attributes:
50:
MSKGPAVGID | LGTTYSCVGV | FQHGKVEIIA | NDQGNRTTPS | YVAFTDTERL |
100:
IGDAAKNQVA | MNPTNTVFDA | KRLIGRRFDD | AVVQSDMKHW | PFMVVNDAGR |
150:
PKVQVEYKGE | TKSFYPEEVS | SMVLTKMKEI | AEAYLGKTVT | NAVVTVPAYF |
200:
NDSQRQATKD | AGTIAGLNVL | RIINEPTAAA | IAYGLDKKVG | AERNVLIFDL |
250:
GGGTFDVSIL | TIEDGIFEVK | STAGDTHLGG | EDFDNRMVNH | FIAEFKRKHK |
300:
KDISENKRAV | RRLRTACERA | KRTLSSSTQA | SIEIDSLYEG | IDFYTSITRA |
350:
RFEELNADLF | RGTLDPVEKA | LRDAKLDKSQ | IHDIVLVGGS | TRIPKIQKLL |
400:
QDFFNGKELN | KSINPDEAVA | YGAAVQAAIL | SGDKSENVQD | LLLLDVTPLS |
450:
LGIETAGGVM | TVLIKRNTTI | PTKQTQTFTT | YSDNQPGVLI | QVYEGERAMT |
500:
KDNNLLGKFE | LTGIPPAPRG | VPQIEVTFDI | DANGILNVSA | VDKSTGKENK |
550:
ITITNDKGRL | SKEDIERMVQ | EAEKYKAEDE | KQRDKVSSKN | SLESYAFNMK |
600:
ATVEDEKLQG | KINDEDKQKI | LDKCNEIISW | LDKNQTAEKE | EFEHQQKELE |
646:
KVCNPIITKL | YQSAGGMPGG | MPGGFPGGGA | PPSGGASSGP | TIEEVD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Chicken
Human
Mouse
Bovine
ELISA Kit for Rat Heat shock cognate 71 kDa protein
ELISA Kit for Rat Heat shock cognate 71 kDa protein
ELISA Kit for Rat Heat shock cognate 71 kDa protein
ELISA Kit for Rat Heat shock cognate 71 kDa protein
ELISA Kit for Rat Heat shock cognate 71 kDa protein
CLIA Kit for Rat Heat shock cognate 71 kDa protein
CLIA Kit for Rat Heat shock cognate 71 kDa protein
CLIA Kit for Rat Heat shock cognate 71 kDa protein
CLIA Kit for Rat Heat shock cognate 71 kDa protein
CLIA Kit for Rat Heat shock cognate 71 kDa protein
Polyclonal Antibody for Rat Heat shock cognate 71 kDa protein
Polyclonal Antibody for Rat Heat shock cognate 71 kDa protein
Polyclonal Antibody for Rat Heat shock cognate 71 kDa protein
Polyclonal Antibody for Rat Heat shock cognate 71 kDa protein
Polyclonal Antibody for Rat Heat shock cognate 71 kDa protein
Monoclonal Antibody for Rat Heat shock cognate 71 kDa protein
Monoclonal Antibody for Rat Heat shock cognate 71 kDa protein
Monoclonal Antibody for Rat Heat shock cognate 71 kDa protein
Monoclonal Antibody for Rat Heat shock cognate 71 kDa protein
Monoclonal Antibody for Rat Heat shock cognate 71 kDa protein
Protein for Rat Heat shock cognate 71 kDa protein
Protein for Rat Heat shock cognate 71 kDa protein
Protein for Rat Heat shock cognate 71 kDa protein
Protein for Rat Heat shock cognate 71 kDa protein
Protein for Rat Heat shock cognate 71 kDa protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Heart .
tissue :
Pituitary .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 4-36; 57-71; 77-108; 127-155; 160-171; 237-246; 300-319; 349-357; 424-447; 452-458; 518-526; 540-550; 584-597 AND 602-609;IDENTIFICATION BY MASS SPECTROMETRY
strain :
Sprague-Dawley .
tissue :
Brain .
tissue :
Hippocampus .
tissue :
Spinal cord .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DNAJC7
6.
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Cited for : STRUCTURE BY NMR OF 385-543