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Index > Protein center > HVCN1(Gene name) > Human
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  • HVCN1 (Gene name),
  • Voltage-gated hydrogen channel 1 (Protein name ),  HVCN1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    HVCN1(UNQ578/PRO1140;VSOP);
    Protein name:
    Voltage-gated hydrogen channel 1;
    Alternative:
    Voltage sensor domain-only protein;Hydrogen voltage-gated channel 1(HV1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    273
    Sequence:
    50:
    MATWDEKAVT | RRAKVAPAER | MSKFLRHFTV | VGDDYHAWNI | NYKKWENEEE | 
    100:
    EEEEEQPPPT | PVSGEEGRAA | APDVAPAPGP | APRAPLDFRG | MLRKLFSSHR | 
    150:
    FQVIIICLVV | LDALLVLAEL | ILDLKIIQPD | KNNYAAMVFH | YMSITILVFF | 
    200:
    MMEIIFKLFV | FRLEFFHHKF | EILDAVVVVV | SFILDIVLLF | QEHQFEALGL | 
    250:
    LILLRLWRVA | RIINGIIISV | KTRSERQLLR | LKQMNVQLAA | KIQHLEFSCS | 
    273:
    EKEQEIERLN | KLLRQHGLLG | EVN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    KEGG:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Voltage-gated hydrogen channel 1
    ELISA Kit for Human Voltage-gated hydrogen channel 1
    ELISA Kit for Human Voltage-gated hydrogen channel 1
    CLIA Kit for Human Voltage-gated hydrogen channel 1
    CLIA Kit for Human Voltage-gated hydrogen channel 1
    CLIA Kit for Human Voltage-gated hydrogen channel 1
    Polyclonal Antibody for Human Voltage-gated hydrogen channel 1
    Polyclonal Antibody for Human Voltage-gated hydrogen channel 1
    Polyclonal Antibody for Human Voltage-gated hydrogen channel 1
    Monoclonal Antibody for Human Voltage-gated hydrogen channel 1
    Monoclonal Antibody for Human Voltage-gated hydrogen channel 1
    Monoclonal Antibody for Human Voltage-gated hydrogen channel 1
    Protein for Human Voltage-gated hydrogen channel 1
    Protein for Human Voltage-gated hydrogen channel 1
    Protein for Human Voltage-gated hydrogen channel 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Cerebellum.
    3. 3.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Eye.
      tissue: Lung.
      tissue: Testis.
    6. 6.
      "A voltage-gated proton-selective channel lacking the pore domain."
      Ramsey I.S. , Moran M.M. , Chong J.A. , Clapham D.E.
      Nature440:1213-1216(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;ENZYME REGULATION;MUTAGENESIS OF HIS-140; HIS-193; ARG-205; ARG-208 AND ARG-211
    7. 7.
      "Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes."
      Musset B. , Capasso M. , Cherny V.V. , Morgan D. , Bhamrah M. , Dyer M.J. , DeCoursey T.E.
      J. Biol. Chem.285:5117-5121(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-29 AND SER-97;MUTAGENESIS OF THR-29 AND SER-97;FUNCTION;SUBCELLULAR LOCATION
    8. 8.
      "Aspartate 112 is the selectivity filter of the human voltage-gated proton channel."
      Musset B. , Smith S.M. , Rajan S. , Morgan D. , Cherny V.V. , Decoursey T.E.
      Nature480:273-277(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-112; HIS-140 AND HIS-193;SUBCELLULAR LOCATION;ENZYME REGULATION
    9. 9.
      "The role and structure of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1."
      Li S.J. , Zhao Q. , Zhou Q. , Unno H. , Zhai Y. , Sun F.
      J. Biol. Chem.285:12047-12054(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 221-273;SUBUNIT;SUBCELLULAR LOCATION;COILED COIL;DOMAIN
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