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Index > Protein center > IL15RA(Gene name) > Human
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  • IL15RA (Gene name),
  • Interleukin-15 receptor subunit alpha (Protein name ),  I15RA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    IL15RA;
    Protein name:
    Interleukin-15 receptor subunit alpha(IL-15 receptor subunit alpha;IL-15R-alpha;IL-15RA);
    Alternative:

    CD:
    CD215;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK.
    Function:
    High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK.
    Subcellular Location:
    Soluble interleukin-15 receptor subunit alpha Secreted extracellular space
    Protein Attributes:
    Sequence length:
    267
    Sequence:
    50:
    MAPRRARGCR | TLGLPALLLL | LLLRPPATRG | ITCPPPMSVE | HADIWVKSYS | 
    100:
    LYSRERYICN | SGFKRKAGTS | SLTECVLNKA | TNVAHWTTPS | LKCIRDPALV | 
    150:
    HQRPAPPSTV | TTAGVTPQPE | SLSPSGKEPA | ASSPSSNNTA | ATTAAIVPGS | 
    200:
    QLMPSKSPST | GTTEISSHES | SHGTPSQTTA | KNWELTASAS | HQPPGVYPQG | 
    250:
    HSDTTVAIST | STVLLCGLSA | VSLLACYLKS | RQTPPLASVE | MEAMEALPVT | 
    267:
    WGTSSRDEDL | ENCSHHL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    UniGene:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-15 receptor subunit alpha
    Cat.:
    E1035m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human IL-15 receptor subunit alpha
    Cat.:
    E1035h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human IL-15 receptor subunit alpha
    Cat.:
    U1035h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-15 receptor subunit alpha
    Cat.:
    U1035m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human IL-15 receptor subunit alpha
    Cat.:
    P1035Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-15 receptor subunit alpha
    Cat.:
    P1035Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IL-15 receptor subunit alpha
    Monoclonal Antibody for Human IL-15 receptor subunit alpha
    Protein for Human IL-15 receptor subunit alpha
    Protein for Human IL-15 receptor subunit alpha

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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes."
      Anderson D.M. , Kumaki S. , Ahdieh M. , Bertles J. , Tometsko M. , Loomis A. , Giri J. , Copeland N.G. , Gilbert D.J. , Jenkins N.A. , Valentine V. , Shapiro D.N. , Morris S.W. , Park L.S. , Cosman D.
      J. Biol. Chem.270:29862-29869(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);FUNCTION;TISSUE SPECIFICITY;VARIANT THR-182
      tissue: Bone marrow stroma.
    2. 2.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2003-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-182
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Trachea.
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 9);VARIANT THR-182
      tissue: Brain.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-267 (ISOFORM 1)
      tissue: Brain.
    9. 9.
      "Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression."
      Dubois S. , Magrangeas F. , Lehours P. , Raher S. , Bernard J. , Boisteau O. , Leroy S. , Minvielle S. , Godard A. , Jacques Y.
      J. Biol. Chem.274:26978-26984(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4; 5; 6; 7 AND 8);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;GLYCOSYLATION
    10. 10.
      "The IL-15R alpha chain signals through association with Syk in human B cells."
      Bulanova E. , Budagian V. , Pohl T. , Krause H. , Durkop H. , Paus R. , Bulfone-Paus S.
      J. Immunol.167:6292-6302(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SYK;PHOSPHORYLATION BY SYK;MUTAGENESIS OF TYR-227
    11. 11.
      "Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain."
      Kurowska M. , Rudnicka W. , Maslinska D. , Maslinski W.
      Ann. N. Y. Acad. Sci.966:441-445(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    12. 12.
      "Identification of an interleukin-15alpha receptor-binding site on human interleukin-15."
      Bernard J. , Harb C. , Mortier E. , Quemener A. , Meloen R.H. , Vermot-Desroches C. , Wijdeness J. , van Dijken P. , Grotzinger J. , Slootstra J.W. , Plet A. , Jacques Y.
      J. Biol. Chem.279:24313-24322(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIGAND-BINDING
    13. 13.
      "Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist."
      Mortier E. , Bernard J. , Plet A. , Jacques Y.
      J. Immunol.173:1681-1688(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;LIGAND-BINDING
    14. 14.
      "The structure of the interleukin-15 alpha receptor and its implications for ligand binding."
      Lorenzen I. , Dingley A.J. , Jacques Y. , Grotzinger J.
      J. Biol. Chem.281:6642-6647(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 31-96;DISULFIDE BONDS
    15. 15.
      "Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans."
      Chirifu M. , Hayashi C. , Nakamura T. , Toma S. , Shuto T. , Kai H. , Yamagata Y. , Davis S.J. , Ikemizu S.
      Nat. Immunol.8:1001-1007(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 31-132 IN COMPLEX WITH IL15;DISULFIDE BONDS
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