Protein name:
Intercellular adhesion molecule 1 (ICAM-1) ;
Alternative:
Major group rhinovirus receptor ;
CD:
CD54 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.
Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MAPSSPRPAL | PALLVLLGAL | FPGPGNAQTS | VSPSKVILPR | GGSVLVTCST |
100:
SCDQPKLLGI | ETPLPKKELL | LPGNNRKVYE | LSNVQEDSQP | MCYSNCPDGQ |
150:
STAKTFLTVY | WTPERVELAP | LPSWQPVGKN | LTLRCQVEGG | APRANLTVVL |
200:
LRGEKELKRE | PAVGEPAEVT | TTVLVRRDHH | GANFSCRTEL | DLRPQGLELF |
250:
ENTSAPYQLQ | TFVLPATPPQ | LVSPRVLEVD | TQGTVVCSLD | GLFPVSEAQV |
300:
HLALGDQRLN | PTVTYGNDSF | SAKASVSVTA | EDEGTQRLTC | AVILGNQSQE |
350:
TLQTVTIYSF | PAPNVILTKP | EVSEGTEVTV | KCEAHPRAKV | TLNGVPAQPL |
400:
GPRAQLLLKA | TPEDNGRSFS | CSATLEVAGQ | LIHKNQTREL | RVLYGPRLDE |
450:
RDCPGNWTWP | ENSQQTPMCQ | AWGNPLPELK | CLKDGTFPLP | IGESVTVTRD |
500:
LEGTYLCRAR | STQGEVTRKV | TVNVLSPRYE | IVIITVVAAA | VIMGTAGLST |
532:
YLYNRQRKIK | KYRLQQAQKG | TPMKPNTQAT | PP
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Dog
Human
Bovine
ELISA Kit for Human ICAM-1
ELISA Kit for Human ICAM-1
ELISA Kit for Human ICAM-1
ELISA Kit for Human ICAM-1
ELISA Kit for Human ICAM-1
CLIA Kit for Human ICAM-1
CLIA Kit for Human ICAM-1
CLIA Kit for Human ICAM-1
CLIA Kit for Human ICAM-1
CLIA Kit for Human ICAM-1
Polyclonal Antibody for Human ICAM-1
Polyclonal Antibody for Human ICAM-1
Polyclonal Antibody for Human ICAM-1
Polyclonal Antibody for Human ICAM-1
Polyclonal Antibody for Human ICAM-1
Monoclonal Antibody for Human ICAM-1
Monoclonal Antibody for Human ICAM-1
Monoclonal Antibody for Human ICAM-1
Monoclonal Antibody for Human ICAM-1
Monoclonal Antibody for Human ICAM-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
BW Liu, Q Lu, CM Ma, et al.
References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLU-469
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-469
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Kidney .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145 AND ASN-267
tissue :
Leukemic T-cell .
23.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
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Santamaria A.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-521 AND THR-530;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 28-217
26.
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Cited for : X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 28-212 IN COMPLEX WITH HUMAN RHINOVIRUS 14
27.
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Cited for : X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 28-212
28.
"Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation."
Shimaoka M.
,
Xiao T.
,
Liu J.H.
,
Yang Y.
,
Dong Y.
,
Jun C.D.
,
McCormack A.
,
Zhang R.
,
Joachimiak A.
,
Takagi J.
,
Wang J.H.
,
Springer T.A.
Cell112:99-111(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 28-318 IN COMPLEX WITH ITGAL VWFA DOMAIN;DISULFIDE BONDS;GLYCOSYLATION AT ASN-130; ASN-145; ASN-183 AND ASN-202
29.
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Cited for : X-RAY CRYSTALLOGRAPHY (3.06 ANGSTROMS) OF 212-477;SUBUNIT;DISULFIDE BONDS;GLYCOSYLATION AT ASN-267; ASN-296 AND ASN-385
30.
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Cited for : STRUCTURE BY ELECTRON CRYOMICROSCOPY (8.0 ANGSTROMS) OF 24-473 IN COMPLEX WITH COXSACKIEVIRUS A21;SUBUNIT
31.
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Cited for : VARIANTS ARG-241 AND GLU-469
32.
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Cited for : VARIANT ARG-241
33.
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Cited for : VARIANT KILIFI MET-56;ASSOCIATION WITH SUSCEPTIBILITY TO MALARIA
34.
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Cited for : VARIANT KILIFI MET-56;VARIANT GLU-469