Protein name:
Inducible T-cell costimulator ;
Alternative:
Activation-inducible lymphocyte immunomediatory molecule ;
CD:
CD278 ;
Organism:
Dog (Canis familiarisCanis lupus familiaris).
General Annotation
Sub Unit:
Homodimer; disulfide-linked.
Function:
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MKSDLWYFLL | FCFQVEALTG | EINDSTKSEM | FTFHDGGVQI | LCKFNAIVSQ |
100:
YKMELLKGTE | VLCDLTTTKE | NGNTVSKNPK | FCQSQSSSDG | VSFFLYNLDS |
150:
SHASYYACQL | SIFDPPPFQR | KNISREYLNV | YESQTCCQLK | FWLPIGCAAF |
200:
VVVYIFGCIF | LCWLTKKKYR | SSVHDPNSEY | MFMAAVNTAK | KPGLTGVTHN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Bovine
Human
Mouse
Dog
ELISA Kit for Dog Inducible T-cell costimulator
ELISA Kit for Dog Inducible T-cell costimulator
ELISA Kit for Dog Inducible T-cell costimulator
ELISA Kit for Dog Inducible T-cell costimulator
ELISA Kit for Dog Inducible T-cell costimulator
CLIA Kit for Dog Inducible T-cell costimulator
CLIA Kit for Dog Inducible T-cell costimulator
CLIA Kit for Dog Inducible T-cell costimulator
CLIA Kit for Dog Inducible T-cell costimulator
CLIA Kit for Dog Inducible T-cell costimulator
Polyclonal Antibody for Dog Inducible T-cell costimulator
Polyclonal Antibody for Dog Inducible T-cell costimulator
Polyclonal Antibody for Dog Inducible T-cell costimulator
Polyclonal Antibody for Dog Inducible T-cell costimulator
Polyclonal Antibody for Dog Inducible T-cell costimulator
Monoclonal Antibody for Dog Inducible T-cell costimulator
Monoclonal Antibody for Dog Inducible T-cell costimulator
Monoclonal Antibody for Dog Inducible T-cell costimulator
Monoclonal Antibody for Dog Inducible T-cell costimulator
Monoclonal Antibody for Dog Inducible T-cell costimulator
Protein for Dog Inducible T-cell costimulator
Protein for Dog Inducible T-cell costimulator
Protein for Dog Inducible T-cell costimulator
Protein for Dog Inducible T-cell costimulator
Protein for Dog Inducible T-cell costimulator
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Cloning and characterization of canine ICOS gene."
Lee J.-H.
,
Kuhr C.
,
Storb R.
Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]