Icos ELISA Kit for Mouse(Mus musculus) | EIAab.comIcos ELISA Kit for Mouse(Mus musculus)

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Icos (Gene name),

Inducible T-cell costimulator (Protein name ), ICOS_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Icos(Ailim);

Protein name:

Inducible T-cell costimulator;

Alternative:

CD28 and CTLA-4-like protein(CCLP);Activation-inducible lymphocyte immunomediatory molecule;CD28-related protein 1(CRP-1);

CD:

CD278;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer; disulfide-linked.

Function:

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

200

Sequence:

50:

100:

150:

200:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9WVS0

UniGene:

Mm.42044

String:

Q9WVS0

KEGG:

mmu:54167

Uniprot:

Q9WVS0

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ELISA Kit for Mouse Inducible T-cell costimulator

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E15375r

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ELISA Kit for Mouse Inducible T-cell costimulator

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E15375b

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ELISA Kit for Mouse Inducible T-cell costimulator

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E15375h

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ELISA Kit for Mouse Inducible T-cell costimulator

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E15375m

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96T

ELISA Kit for Mouse Inducible T-cell costimulator

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E15375d

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96T

CLIA Kit for Mouse Inducible T-cell costimulator

Cat.:

U15375m

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96T

CLIA Kit for Mouse Inducible T-cell costimulator

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U15375d

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96T

CLIA Kit for Mouse Inducible T-cell costimulator

Cat.:

U15375h

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96T

CLIA Kit for Mouse Inducible T-cell costimulator

Cat.:

U15375r

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96T

CLIA Kit for Mouse Inducible T-cell costimulator

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U15375b

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96T

Polyclonal Antibody for Mouse Inducible T-cell costimulator

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P15375Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Inducible T-cell costimulator

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P15375Rb-m

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Polyclonal Antibody for Mouse Inducible T-cell costimulator

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P15375Rb-h

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Monoclonal Antibody for Mouse Inducible T-cell costimulator

Protein for Mouse Inducible T-cell costimulator

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"T-cell co-stimulation through B7RP-1 and ICOS."
Yoshinaga S.K. , Whoriskey J.S. , Khare S.D. , Sarmiento U. , Guo J. , Horan T. , Shih G. , Zhang M. , Coccia M.A. , Kohno T. , Tafuri-Bladt A. , Brankow D. , Campbell P. , Chang D. , Chiu L. , Dai T. , Duncan G. , Elliott G.S. , more...
Nature402:827-832(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE;FUNCTION;TISSUE SPECIFICITY
tissue: Intestinal epithelium.
2.

"Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family."
Tezuka K. , Tsuji T. , Hirano D. , Tamatani T. , Sakamaki K. , Kobayashi Y. , Kamada M.
Biochem. Biophys. Res. Commun.276:335-345(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE;TISSUE SPECIFICITY
tissue: Spleen.
3.

"Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand."
Mages H.W. , Hutloff A. , Heuck C. , Buechner K. , Himmelbauer H. , Oliveri F. , Kroczek R.A.
Eur. J. Immunol.30:1040-1047(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];GLYCOSYLATION;SUBUNIT;TISSUE SPECIFICITY
strain: BALB/c.
tissue: Spleen.
4.

"The inducible costimulatory (ICOS) molecule is critical for CD40-mediated antibody class switching."
McAdam A.J. , Greenwald R.J. , Levin M.A. , Chernova T. , Malenkovich N. , Ling V. , Freeman G.J. , Sharpe A.H.
Nature409:102-105(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE;FUNCTION
strain: 129/Ola.
5.

"CCLP, A novel molecule that regulates T cell activation."
Wu D. , Giannoni M.A. , Kiesecker C.L. , Faas S.J. , Mickle A.P. , Matis L.A. , Rother R.P.
Submitted (2000-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE
strain: BALB/c.
tissue: Spleen.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Mammary gland.
7.

"ICOS is essential for effective T-helper-cell responses."
Tafuri A. , Shahinian A. , Bladt F. , Yoshinaga S.K. , Jordana M. , Wakeham A. , Boucher L.-M. , Bouchard D. , Chan V.S. , Duncan G. , Odermatt B. , Ho A. , Itie A. , Horan T. , Whoriskey J.S. , Pawson T. , Penninger J.M. , Ohashi P.S. , more...
Nature409:105-109(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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