Gene name:
EIF4A1 (DDX2A;EIF4A) ;
Protein name:
Eukaryotic initiation factor 4A-I (eIF-4A-I;eIF4A-I) ;
Alternative:
ATP-dependent RNA helicase eIF4A-1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4.
Function:
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Subcellular Location:
N/A
Protein Attributes:
50:
MSASQDSRSR | DNGPDGMEPE | GVIESNWNEI | VDSFDDMNLS | ESLLRGIYAY |
100:
GFEKPSAIQQ | RAILPCIKGY | DVIAQAQSGT | GKTATFAISI | LQQIELDLKA |
150:
TQALVLAPTR | ELAQQIQKVV | MALGDYMGAS | CHACIGGTNV | RAEVQKLQME |
200:
APHIIVGTPG | RVFDMLNRRY | LSPKYIKMFV | LDEADEMLSR | GFKDQIYDIF |
250:
QKLNSNTQVV | LLSATMPSDV | LEVTKKFMRD | PIRILVKKEE | LTLEGIRQFY |
300:
INVEREEWKL | DTLCDLYETL | TITQAVIFIN | TRRKVDWLTE | KMHARDFTVS |
350:
AMHGDMDQKE | RDVIMREFRS | GSSRVLITTD | LLARGIDVQQ | VSLVINYDLP |
400:
TNRENYIHRI | GRGGRFGRKG | VAINMVTEED | KRTLRDIETF | YNTSIEEMPL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rabbit
Human
Mouse
ELISA Kit for Human eIF-4A-I
ELISA Kit for Human eIF-4A-I
ELISA Kit for Human eIF-4A-I
ELISA Kit for Human eIF-4A-I
CLIA Kit for Human eIF-4A-I
CLIA Kit for Human eIF-4A-I
CLIA Kit for Human eIF-4A-I
CLIA Kit for Human eIF-4A-I
Polyclonal Antibody for Human eIF-4A-I
Polyclonal Antibody for Human eIF-4A-I
Polyclonal Antibody for Human eIF-4A-I
Polyclonal Antibody for Human eIF-4A-I
Monoclonal Antibody for Human eIF-4A-I
Monoclonal Antibody for Human eIF-4A-I
Monoclonal Antibody for Human eIF-4A-I
Monoclonal Antibody for Human eIF-4A-I
Protein for Human eIF-4A-I
Protein for Human eIF-4A-I
Protein for Human eIF-4A-I
Protein for Human eIF-4A-I
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Heart .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Bone marrow .
tissue :
Lung .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PAIP1
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UPF2
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH EIF4E
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN A COMPLEX WITH XPO7; ARHGAP1; VPS26A; VPS29; VPS35 AND SFN
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POSSIBLE INTERACTION WITH NOM1
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RBM4
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-118 AND LYS-174;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HHV-5 PROTEIN UL69
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) IN COMPLEX WITH PDCD4;FUNCTION;SUBUNIT;ENZYME REGULATION
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 20-406 IN COMPLEX WITH PDCD4;FUNCTION;ENZYME REGULATION;SUBUNIT
20.
"Comparative structural analysis of human DEAD-box RNA helicases."
Schutz P.
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Karlberg T.
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van den Berg S.
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Collins R.
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Lehtio L.
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Hogbom M.
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Holmberg-Schiavone L.
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PLoS ONE5:E12791-E12791(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 20-236