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Index > Protein center > EIF4A1(Gene name) > Human
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  • EIF4A1 (Gene name),
  • Eukaryotic initiation factor 4A-I (Protein name ),  IF4A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EIF4A1(DDX2A;EIF4A);
    Protein name:
    Eukaryotic initiation factor 4A-I(eIF-4A-I;eIF4A-I);
    Alternative:
    ATP-dependent RNA helicase eIF4A-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4.
    Function:
    ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    406
    Sequence:
    50:
    MSASQDSRSR | DNGPDGMEPE | GVIESNWNEI | VDSFDDMNLS | ESLLRGIYAY | 
    100:
    GFEKPSAIQQ | RAILPCIKGY | DVIAQAQSGT | GKTATFAISI | LQQIELDLKA | 
    150:
    TQALVLAPTR | ELAQQIQKVV | MALGDYMGAS | CHACIGGTNV | RAEVQKLQME | 
    200:
    APHIIVGTPG | RVFDMLNRRY | LSPKYIKMFV | LDEADEMLSR | GFKDQIYDIF | 
    250:
    QKLNSNTQVV | LLSATMPSDV | LEVTKKFMRD | PIRILVKKEE | LTLEGIRQFY | 
    300:
    INVEREEWKL | DTLCDLYETL | TITQAVIFIN | TRRKVDWLTE | KMHARDFTVS | 
    350:
    AMHGDMDQKE | RDVIMREFRS | GSSRVLITTD | LLARGIDVQQ | VSLVINYDLP | 
    400:
    TNRENYIHRI | GRGGRFGRKG | VAINMVTEED | KRTLRDIETF | YNTSIEEMPL | 
    406:
    NVADLI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human eIF-4A-I
    ELISA Kit for Human eIF-4A-I
    ELISA Kit for Human eIF-4A-I
    ELISA Kit for Human eIF-4A-I
    CLIA Kit for Human eIF-4A-I
    CLIA Kit for Human eIF-4A-I
    CLIA Kit for Human eIF-4A-I
    CLIA Kit for Human eIF-4A-I
    Polyclonal Antibody for Human eIF-4A-I
    Polyclonal Antibody for Human eIF-4A-I
    Polyclonal Antibody for Human eIF-4A-I
    Polyclonal Antibody for Human eIF-4A-I
    Monoclonal Antibody for Human eIF-4A-I
    Monoclonal Antibody for Human eIF-4A-I
    Monoclonal Antibody for Human eIF-4A-I
    Monoclonal Antibody for Human eIF-4A-I
    Protein for Human eIF-4A-I
    Protein for Human eIF-4A-I
    Protein for Human eIF-4A-I
    Protein for Human eIF-4A-I

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    Precision
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    Linearity
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    References
    1. 1.
      "Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI."
      Kim N.-S. , Kato T. , Abe N. , Kato S.
      Nucleic Acids Res.21:2012-2012(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Heart.
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Bone marrow.
      tissue: Lung.
    6. 7.
      "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation."
      Craig A.W.B. , Haghighat A. , Yu A.T.K. , Sonenberg N.
      Nature392:520-523(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PAIP1
    7. 8.
      "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes."
      Mendell J.T. , Medghalchi S.M. , Lake R.G. , Noensie E.N. , Dietz H.C.
      Mol. Cell. Biol.20:8944-8957(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UPF2
    8. 9.
      "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo."
      Li W. , Belsham G.J. , Proud C.G.
      J. Biol. Chem.276:29111-29115(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF4E
    9. 10.
      "Exportin 7 defines a novel general nuclear export pathway."
      Mingot J.-M. , Bohnsack M.T. , Jaekle U. , Goerlich D.
      EMBO J.23:3227-3236(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH XPO7; ARHGAP1; VPS26A; VPS29; VPS35 AND SFN
    10. 11.
      "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia."
      Simmons H.M. , Ruis B.L. , Kapoor M. , Hudacek A.W. , Conklin K.F.
      Gene347:137-145(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INTERACTION WITH NOM1
    11. 12.
      "Cell stress modulates the function of splicing regulatory protein RBM4 in translation control."
      Lin J.C. , Hsu M. , Tarn W.Y.
      Proc. Natl. Acad. Sci. U.S.A.104:2235-2240(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBM4
    12. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 14.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-118 AND LYS-174;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 15.
      "Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1."
      Aoyagi M. , Gaspar M. , Shenk T.E.
      Proc. Natl. Acad. Sci. U.S.A.107:2640-2645(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-5 PROTEIN UL69
    15. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 17.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    17. 18.
      "Structural basis for translational inhibition by the tumour suppressor Pdcd4."
      Loh P.G. , Yang H.S. , Walsh M.A. , Wang Q. , Wang X. , Cheng Z. , Liu D. , Song H.
      EMBO J.28:274-285(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) IN COMPLEX WITH PDCD4;FUNCTION;SUBUNIT;ENZYME REGULATION
    18. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 20-406 IN COMPLEX WITH PDCD4;FUNCTION;ENZYME REGULATION;SUBUNIT
    19. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 20-236
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