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Index > Protein center > Eif4a1(Gene name) > Mouse
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  • Eif4a1 (Gene name),
  • Eukaryotic initiation factor 4A-I (Protein name ),  IF4A1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Eif4a1(Ddx2a;Eif4a);
    Protein name:
    Eukaryotic initiation factor 4A-I(eIF-4A-I;eIF4A-I);
    Alternative:
    ATP-dependent RNA helicase eIF4A-1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4.
    Function:
    ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    406
    Sequence:
    50:
    MSASQDSRSR | DNGPDGMEPE | GVIESNWNEI | VDSFDDMNLS | ESLLRGIYAY | 
    100:
    GFEKPSAIQQ | RAILPCIKGY | DVIAQAQSGT | GKTATFAISI | LQQIELDLKA | 
    150:
    TQALVLAPTR | ELAQQIQKVV | MALGDYMGAS | CHACIGGTNV | RAEVQKLQME | 
    200:
    APHIIVGTPG | RVFDMLNRRY | LSPKYIKMFV | LDEADEMLSR | GFKDQIYDIF | 
    250:
    QKLNSNTQVV | LLSATMPSDV | LEVTKKFMRD | PIRILVKKEE | LTLEGIRQFY | 
    300:
    INVEREEWKL | DTLCDLYETL | TITQAVIFIN | TRRKVDWLTE | KMHARDFTVS | 
    350:
    AMHGDMDQKE | RDVIMREFRS | GSSRVLITTD | LLARGIDVQQ | VSLVINYDLP | 
    400:
    TNRENYIHRI | GRGGRFGRKG | VAINMVTEED | KRTLRDIETF | YNTSIEEMPL | 
    406:
    NVADLI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    KEGG:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse eIF-4A-I
    ELISA Kit for Mouse eIF-4A-I
    ELISA Kit for Mouse eIF-4A-I
    ELISA Kit for Mouse eIF-4A-I
    CLIA Kit for Mouse eIF-4A-I
    CLIA Kit for Mouse eIF-4A-I
    CLIA Kit for Mouse eIF-4A-I
    CLIA Kit for Mouse eIF-4A-I
    Polyclonal Antibody for Mouse eIF-4A-I
    Polyclonal Antibody for Mouse eIF-4A-I
    Polyclonal Antibody for Mouse eIF-4A-I
    Polyclonal Antibody for Mouse eIF-4A-I
    Monoclonal Antibody for Mouse eIF-4A-I
    Monoclonal Antibody for Mouse eIF-4A-I
    Monoclonal Antibody for Mouse eIF-4A-I
    Monoclonal Antibody for Mouse eIF-4A-I
    Protein for Mouse eIF-4A-I
    Protein for Mouse eIF-4A-I
    Protein for Mouse eIF-4A-I
    Protein for Mouse eIF-4A-I

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    References
    1. 1.
      "Cloning of eukaryotic protein synthesis initiation factor genes: isolation and characterization of cDNA clones encoding factor eIF-4A."
      Nielsen P.J. , McMaster G.K. , Trachsel H.
      Nucleic Acids Res.13:6867-6880(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells."
      Reddy N.S. , Roth W.W. , Bragg P.W. , Wahba A.J.
      Gene70:231-243(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      Miyashita A. , Shimizu N. , Nakajima T. , Odani S. , Kuwano R.
      Submitted (1998-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Czech II.
      tissue: Mammary gland.
    6. 6.
      "Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A."
      Pause A. , Somenberg N.
      EMBO J.11:2643-2654(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
    7. 7.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-193 AND LYS-238;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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