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Index > Protein center > EIF4A2(Gene name) > Human
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  • EIF4A2 (Gene name),
  • Eukaryotic initiation factor 4A-II (Protein name ),  IF4A2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    EIF4A2(DDX2B;EIF4F);
    Protein name:
    Eukaryotic initiation factor 4A-II(eIF-4A-II;eIF4A-II);
    Alternative:
    ATP-dependent RNA helicase eIF4A-2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E. May interact with NOM1. Interacts with HHV-1 Vhs.
    Function:
    ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    407
    Sequence:
    50:
    MSGGSADYNR | EHGGPEGMDP | DGVIESNWNE | IVDNFDDMNL | KESLLRGIYA | 
    100:
    YGFEKPSAIQ | QRAIIPCIKG | YDVIAQAQSG | TGKTATFAIS | ILQQLEIEFK | 
    150:
    ETQALVLAPT | RELAQQIQKV | ILALGDYMGA | TCHACIGGTN | VRNEMQKLQA | 
    200:
    EAPHIVVGTP | GRVFDMLNRR | YLSPKWIKMF | VLDEADEMLS | RGFKDQIYEI | 
    250:
    FQKLNTSIQV | VLLSATMPTD | VLEVTKKFMR | DPIRILVKKE | ELTLEGIKQF | 
    300:
    YINVEREEWK | LDTLCDLYET | LTITQAVIFL | NTRRKVDWLT | EKMHARDFTV | 
    350:
    SALHGDMDQK | ERDVIMREFR | SGSSRVLITT | DLLARGIDVQ | QVSLVINYDL | 
    400:
    PTNRENYIHR | IGRGGRFGRK | GVAINFVTEE | DKRILRDIET | FYNTTVEEMP | 
    407:
    MNVADLI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    SMR:
    UniGene:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human eIF-4A-II
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    ELISA Kit for Human eIF-4A-II
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    ELISA Kit for Human eIF-4A-II
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    ELISA Kit for Human eIF-4A-II
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    E11466r
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    ELISA Kit for Human eIF-4A-II
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    CLIA Kit for Human eIF-4A-II
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    CLIA Kit for Human eIF-4A-II
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    CLIA Kit for Human eIF-4A-II
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    U11466r
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    96T
    CLIA Kit for Human eIF-4A-II
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    U11466m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human eIF-4A-II
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    Polyclonal Antibody for Human eIF-4A-II
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    P11466Rb-r
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    Polyclonal Antibody for Human eIF-4A-II
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    Polyclonal Antibody for Human eIF-4A-II
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human eIF-4A-II
    Polyclonal Antibody for Human eIF-4A-II
    Monoclonal Antibody for Human eIF-4A-II
    Monoclonal Antibody for Human eIF-4A-II
    Monoclonal Antibody for Human eIF-4A-II
    Monoclonal Antibody for Human eIF-4A-II
    Monoclonal Antibody for Human eIF-4A-II
    Protein for Human eIF-4A-II
    Protein for Human eIF-4A-II
    Protein for Human eIF-4A-II
    Protein for Human eIF-4A-II
    Protein for Human eIF-4A-II

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    References
    1. 1.
      "Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2."
      Sudo K. , Takahashi E. , Nakamura Y.
      Cytogenet. Cell Genet.71:385-388(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Lung.
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Bone marrow.
      tissue: Brain.
      tissue: Lymph.
      tissue: Skeletal muscle.
    6. 6.
      "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo."
      Li W. , Belsham G.J. , Proud C.G.
      J. Biol. Chem.276:29111-29115(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF4E
    7. 7.
      "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia."
      Simmons H.M. , Ruis B.L. , Kapoor M. , Hudacek A.W. , Conklin K.F.
      Gene347:137-145(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INTERACTION WITH NOM1
    8. 8.
      "mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A."
      Feng P. , Everly D.N. Jr. , Read G.S.
      J. Virol.79:9651-9664(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-1 VHS
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 22-240
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-181
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