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Index > Protein center > EIF4E2(Gene name) > Human
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  • EIF4E2 (Gene name),
  • Eukaryotic translation initiation factor 4E type 2 (Protein name ),  IF4E2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EIF4E2(EIF4EL3);
    Protein name:
    Eukaryotic translation initiation factor 4E type 2(eIF-4E type 2;eIF4E type 2);
    Alternative:
    Eukaryotic translation initiation factor 4E-like 3;Eukaryotic translation initiation factor 4E homologous protein;mRNA cap-binding protein 4EHP;eIF4E-like protein 4E-LP;mRNA cap-binding protein type 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners (By similarity). EIF4E2 interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3 but not with eIF4G.
    Function:
    Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    245
    Sequence:
    50:
    MNNKFDALKD | DDSGDHDQNE | ENSTQKDGEK | EKTERDKNQS | SSKRKAVVPG | 
    100:
    PAEHPLQYNY | TFWYSRRTPG | RPTSSQSYEQ | NIKQIGTFAS | VEQFWRFYSH | 
    150:
    MVRPGDLTGH | SDFHLFKEGI | KPMWEDDANK | NGGKWIIRLR | KGLASRCWEN | 
    200:
    LILAMLGEQF | MVGEEICGAV | VSVRFQEDII | SIWNKTASDQ | ATTARIRDTL | 
    245:
    RRVLNLPPNT | IMEYKTHTDS | IKMPGRLGPQ | RLLFQNLWKP | RLNVP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human eIF-4E type 2
    ELISA Kit for Human eIF-4E type 2
    CLIA Kit for Human eIF-4E type 2
    CLIA Kit for Human eIF-4E type 2
    Polyclonal Antibody for Human eIF-4E type 2
    Polyclonal Antibody for Human eIF-4E type 2
    Monoclonal Antibody for Human eIF-4E type 2
    Monoclonal Antibody for Human eIF-4E type 2
    Protein for Human eIF-4E type 2
    Protein for Human eIF-4E type 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein."
      Rom E. , Kim H.C. , Gingras A.-C. , Marcotrigiano J. , Favre D. , Olsen H. , Burley S.K. , Sonenberg N.
      J. Biol. Chem.273:13104-13109(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION;3D-STRUCTURE MODELING;MUTAGENESIS
      tissue: Follicular cell.
    2. 2.
      "Characterization of mammalian eIF4E-family members."
      Joshi B. , Cameron A. , Jagus R.
      Eur. J. Biochem.271:2189-2203(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH EIF4EBP1; EIF4EBP2 AND EIF4EBP3
      tissue: Mammary gland.
    3. 3.
      "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
      Mao M. , Fu G. , Wu J.-S. , Zhang Q.-H. , Zhou J. , Kan L.-X. , Huang Q.-H. , He K.-L. , Gu B.-W. , Han Z.-G. , Shen Y. , Gu J. , Yu Y.-P. , Xu S.-H. , Wang Y.-X. , Chen S.-J. , Chen Z.
      Proc. Natl. Acad. Sci. U.S.A.95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Umbilical cord blood.
    4. 4.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Muscle.
      tissue: Urinary bladder.
      tissue: Uterus.
    7. 7.
      "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP."
      Tan N.G. , Ardley H.C. , Scott G.B. , Rose S.A. , Markham A.F. , Robinson P.A.
      FEBS Lett.554:501-504(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY ARIH1
    8. 8.
      "ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP."
      Okumura F. , Zou W. , Zhang D.E.
      Genes Dev.21:255-260(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION AT LYS-134 AND LYS-222
    9. 9.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-134;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms."
      Rosettani P. , Knapp S. , Vismara M.-G. , Rusconi L. , Cameron A.D.
      J. Mol. Biol.368:691-705(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 45-234 IN COMPLEX WITH MRNA CAP ANALOGS AND EIF4EBP1
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