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Index > Protein center > Eif4g3(Gene name) > Mouse
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  • Eif4g3 (Gene name),
  • Eukaryotic translation initiation factor 4 gamma 3 (Protein name ),  IF4G3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Eif4g3;
    Protein name:
    Eukaryotic translation initiation factor 4 gamma 3(eIF-4-gamma 3;eIF-4G 3;eIF4G 3);
    Alternative:
    eIF-4-gamma II(eIF4GII);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA.
    Function:
    Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    1579
    Sequence:
    50:
    MNSQPQARSP | FFQRPQIQPP | RAAIPNSSPS | IRPGVQTPTA | VYQANQHIMM | 
    100:
    VNHLPMPYPV | TQGHQYCIPQ | YRHSGPPYVG | PPQQYPVQPP | GPGPFYPGPG | 
    150:
    PGDFANAYGT | PFYPSQPVYQ | SAPIIVPTQQ | QPPPAKREKK | TIRIRDPNQG | 
    200:
    GKDITEEIMS | GGGSRNPTPP | IGRPASTPTP | PQQLPSQVPE | HSPVVYGTVE | 
    250:
    SAHLAASTPV | TAASDQKQEE | KPKPDPVFQS | PSTVLRLVLS | GEKKEQAGQM | 
    300:
    PETAAGEPTP | EPPRTSSPTS | LPPLARSSLP | SPMSAALSSQ | PLFTAEDKCE | 
    350:
    LPSSKEEDAP | PVPSPTSCTA | ASGPSLTDNS | DICKKPCSVA | PHDSQLISST | 
    400:
    ILINEMNGVG | EKLSAKENTV | GMLRQEVLPL | TLELEILEHP | QEELKVECTP | 
    450:
    TPIAPSMLPA | FSPAPPTPPT | SPPCPPVVLS | AAIARSPAVA | TEVQRVADEG | 
    500:
    ESLRTCLSKD | AKEMQDKAES | ESDGQAEETA | DPQSLHSGRS | PAPVQTATTA | 
    550:
    PKSWKKTKEQ | TRTPDEVLEA | EAEPKAEEEL | AVDSVLEPEQ | EKMSQGFPSE | 
    600:
    RDPSALKRGK | AEEGNGEEAE | PVRNGAESAS | EGEGGDGNSG | SADSSADGLT | 
    650:
    FPFKAESWKP | ADTEGKKQYD | REFLLDIQFM | PACIQKPEGL | PPISDVVLDK | 
    700:
    INQPRLSMRT | LDPRILPRGP | DFTPAFADFP | RQTPGGRGVP | LLNVGPRRSQ | 
    750:
    PGQRREPRKI | ITVSVKEDVH | LRKAENAWKP | SQKRDSHADD | PESIKTQELF | 
    800:
    RKVRSILNKL | TPQMFNQLMK | QVSALTVDTE | ERLKGVIDLV | FEKAIDEPSF | 
    850:
    SVAYANMCRC | LVTLKVPMAD | KPGNTVNFRK | LLLNRCQKEF | EKDKADDDVF | 
    900:
    EKKQKELEAA | SAPEERTRLH | DELEEAKDKA | RRRSIGNIKF | IGELFKLKML | 
    950:
    TEAIMHDCVV | KLLKNHDEES | LECLCRLLTT | IGKDLDFEKA | KPRMDQYFNQ | 
    1000:
    MEKIVKERKT | SSRIRFMLQD | VIDLRLCNWV | SRRADQGPKT | IEQIHKEAKI | 
    1050:
    EEQEEQRKVQ | QLMTKEKRRP | GVQRVDEGGW | NTVQGAKNSR | VLDPSKFLKI | 
    1100:
    TKPTIDEKIQ | LVPKAQLGSW | GKGSSGGAKA | SESDALRSSA | SSLNRFSPLQ | 
    1150:
    PPAPSGSPSA | TPLEFDSRRA | LTSRGSMGRE | KSDKPIPAGT | ARPNTFLRGS | 
    1200:
    SKDLLDNQSQ | EEQRREMLET | VKQLTGGLDA | ERASTEADRS | KTRELAKSEM | 
    1250:
    CAVPAPDKPA | LSEEEVERKS | KSIIDEFLHI | NDFKEATQCI | EELSAQGPLH | 
    1300:
    VFVKVGVEFT | LERSQITRDH | MGHLLYQLVQ | SEKLSKQDFF | KGFSETLELA | 
    1350:
    DDMAIDIPHI | WLYLAELVTP | MLKEGGISMR | ELIVEFSKPL | LPVGRAGVLL | 
    1400:
    SEILHLLCRQ | MSHKKVGALW | READLSWKDF | LPEGEDVHHF | LLEQKLDFTE | 
    1450:
    SEGPCSSEAL | SKKELSAEEL | SQRLEKLIME | EKADDERIFD | WVEANLDESQ | 
    1500:
    MSSPTFLRAL | MTAVCKAAII | ADCSTFRVDT | AVIKQRVPIL | LKYLDSDTEK | 
    1550:
    ELQALYALQA | SIVKLDQPAN | LLRMFFDCLY | DEEVISEDAF | YKWESSKDPA | 
    1579:
    EQAGKGVALK | SVTAFFTWLR | EAEEESEDN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse eIF-4-gamma 3
    ELISA Kit for Mouse eIF-4-gamma 3
    CLIA Kit for Mouse eIF-4-gamma 3
    CLIA Kit for Mouse eIF-4-gamma 3
    Polyclonal Antibody for Mouse eIF-4-gamma 3
    Polyclonal Antibody for Mouse eIF-4-gamma 3
    Monoclonal Antibody for Mouse eIF-4-gamma 3
    Monoclonal Antibody for Mouse eIF-4-gamma 3
    Protein for Mouse eIF-4-gamma 3
    Protein for Mouse eIF-4-gamma 3

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-217 AND 807-1579 (ISOFORM 2);NUCLEOTIDE SEQUENCE OF 1-135 (ISOFORM 3)
      strain: C57BL/6J.
      tissue: Adipose tissue.
      tissue: Head.
      tissue: Oviduct.
    2. 2.
      The MGC Project Team
      Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 164-492
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4)
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Brain.
      tissue: Colon.
      tissue: Kidney.
      tissue: Liver.
      tissue: Mammary tumor.
    4. 4.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-168; SER-267; SER-470 AND SER-472;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    6. 6.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-472;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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