IHH ELISA Kit for Human(Homo sapiens) | EIAab.comIHH ELISA Kit for Human(Homo sapiens)

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IHH (Gene name),

Indian hedgehog protein (Protein name ), IHH_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IHH;

Protein name:

Indian hedgehog protein(IHH);

Alternative:

HHG-2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).

Subcellular Location:

Indian hedgehog protein C-product Secreted extracellular space The C-terminal peptide diffuses from the cell.

Protein Attributes:

Sequence length:

411

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

411:

FHPLGMSGAG | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000295731

KEGG:

hsa:3549

String:

Q14623

MIM:

112500

UniGene:

Hs.654504

SMR:

Q14623

Pfam:

PF01085

Uniprot:

Q14623

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ELISA Kit for Human IHH

Cat.:

E0025m

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MSDS:

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Packing:

96T

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ELISA Kit for Human IHH

Cat.:

E0025h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human IHH

Cat.:

E0025c

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MSDS:

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Packing:

96T

CLIA Kit for Human IHH

Cat.:

U0025m

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MSDS:

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Packing:

96T

CLIA Kit for Human IHH

Cat.:

U0025h

Price:

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human IHH

Cat.:

U0025c

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human IHH

Cat.:

P0025Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human IHH

Cat.:

P0025Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human IHH

Protein for Human IHH

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression of Sonic hedgehog and its receptor Patched/Smoothened in human cancer cell lines and embryonic organs."
Tate G. , Kishimoto K. , Mitsuya T.
J. Biochem. Mol. Biol. Biophys.4:27-34(2000)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Testis.
4.

"Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog."
Marigo V. , Roberts D.J. , Lee S.M.K. , Tsukurov O. , Levi T. , Gastier J.M. , Epstein D.J. , Gilbert D.J. , Copeland N.G. , Seidman C.E. , Jenkins N.A. , Seidman J.G. , McMahon A.P. , Tabin C.
Genomics28:44-51(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 100-411
tissue: Fetal lung.
5.

"Products, genetic linkage and limb patterning activity of a murine hedgehog gene."
Chang D.T. , Lopez A. , von Kessler D.P. , Chiang C. , Simandl B.K. , Zhao R. , Seldin M.F. , Fallon J.F. , Beachy P.A.
Development120:3339-3353(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 124-172
6.

"Identification of a palmitic acid-modified form of human Sonic hedgehog."
Pepinsky R.B. , Zeng C. , Wen D. , Rayhorn P. , Baker D.P. , Williams K.P. , Bixler S.A. , Ambrose C.M. , Garber E.A. , Miatkowski K. , Taylor F.R. , Wang E.A. , Galdes A.
J. Biol. Chem.273:14037-14045(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-28
7.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-282
tissue: Plasma.
8.

"All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner."
Kavran J.M. , Ward M.D. , Oladosu O.O. , Mulepati S. , Leahy D.J.
J. Biol. Chem.285:24584-24590(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 29-193 IN COMPLEXES WITH CALCIUM IONS; ZINC IONS; BOC AND CDON;DOMAIN;INTERACTION WITH BOC AND CDON
9.

"Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels."
Ma G. , Yu J. , Xiao Y. , Chan D. , Gao B. , Hu J. , He Y. , Guo S. , Zhou J. , Zhang L. , Gao L. , Zhang W. , Kang Y. , Cheah K.S. , Feng G. , Guo X. , Wang Y. , Zhou C.Z. , more...
Cell Res.21:1343-1357(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 28-202 OF WILD TYPE AND VARIANTS BDA1 LYS-95; GLU-100 AND LYS-131 IN COMPLEX WITH ZINC IONS;FUNCTION;SUBUNIT;INTERACTION WITH PTCH1;SUBCELLULAR LOCATION;CHOLESTERYLATION;PALMITOYLATION;MUTAGENESIS OF GLU-95;DOMAIN;CHARACTERIZATION OF VARIANTS BDA1 LYS-95; ASN-100; GLU-100 AND LYS-131
10.

"Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1."
Gao B. , Guo J. , She C. , Shu A. , Yang M. , Tan Z. , Yang X. , Guo S. , Feng G. , He L.
Nat. Genet.28:386-388(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BDA1 LYS-95; GLU-100 AND LYS-131
11.

"A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved."
McCready M.E. , Sweeney E. , Fryer A.E. , Donnai D. , Baig A. , Racacho L. , Warman M.L. , Hunter A.G.W. , Bulman D.E.
Hum. Genet.111:368-375(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BDA1 ASN-100
12.

"Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips."
Hellemans J. , Coucke P.J. , Giedion A. , De Paepe A. , Kramer P. , Beemer F. , Mortier G.R.
Am. J. Hum. Genet.72:1040-1046(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ACFD LEU-46 AND ALA-190

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