Protein name:
NF-kappa-B inhibitor alpha ;
Alternative:
I-kappa-B-alpha (IkB-alpha;IkappaBalpha) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with PRMT2 (By similarity). Interacts with RELA; the interaction requires the nuclear import signal. Interacts with NKIRAS1 and NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HBV protein X. Interacts with RWDD3; the interaction enhances sumoylation. Interacts (when phosphorylated at the 2 serine residues in the destruction motif D-S-G-X(2,3,4)-S) with BTRC. Associates with the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC; the association is mediated via interaction with BTRC. Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with RELA; RELA interacts directly with NFKBIA.
Function:
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
Subcellular Location:
Cytoplasm
Nucleus
Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Protein Attributes:
50:
MFQPAGHGQD | WAMEGPRDGL | KKERLVDDRH | DSGLDSMKDE | EYEQMVKELR |
100:
EIRLQPQEAP | LAAEPWKQQL | TEDGDSFLHL | AIIHEEKPLT | MEVIGQVKGD |
150:
LAFLNFQNNL | QQTPLHLAVI | TNQPGIAEAL | LKAGCDPELR | DFRGNTPLHL |
200:
ACEQGCLASV | AVLTQTCTPQ | HLHSVLQATN | YNGHTCLHLA | SIHGYLAIVE |
250:
HLVTLGADVN | AQEPCNGRTA | LHLAVDLQNP | DLVSLLLKCG | ADVNRVTYQG |
300:
YSPYQLTWGR | PSTRIQQQLG | QLTLENLQML | PESEDEESYD | TESEFTEDEL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Pig
Mouse
Chicken
ELISA Kit for Mouse NF-kappa-B inhibitor alpha
ELISA Kit for Mouse NF-kappa-B inhibitor alpha
ELISA Kit for Mouse NF-kappa-B inhibitor alpha
ELISA Kit for Mouse NF-kappa-B inhibitor alpha
ELISA Kit for Mouse NF-kappa-B inhibitor alpha
CLIA Kit for Mouse NF-kappa-B inhibitor alpha
CLIA Kit for Mouse NF-kappa-B inhibitor alpha
CLIA Kit for Mouse NF-kappa-B inhibitor alpha
CLIA Kit for Mouse NF-kappa-B inhibitor alpha
CLIA Kit for Mouse NF-kappa-B inhibitor alpha
Polyclonal Antibody for Mouse NF-kappa-B inhibitor alpha
Polyclonal Antibody for Mouse NF-kappa-B inhibitor alpha
Polyclonal Antibody for Mouse NF-kappa-B inhibitor alpha
Polyclonal Antibody for Mouse NF-kappa-B inhibitor alpha
Polyclonal Antibody for Mouse NF-kappa-B inhibitor alpha
Monoclonal Antibody for Mouse NF-kappa-B inhibitor alpha
Monoclonal Antibody for Mouse NF-kappa-B inhibitor alpha
Monoclonal Antibody for Mouse NF-kappa-B inhibitor alpha
Monoclonal Antibody for Mouse NF-kappa-B inhibitor alpha
Monoclonal Antibody for Mouse NF-kappa-B inhibitor alpha
Protein for Mouse NF-kappa-B inhibitor alpha
Protein for Mouse NF-kappa-B inhibitor alpha
Protein for Mouse NF-kappa-B inhibitor alpha
Protein for Mouse NF-kappa-B inhibitor alpha
Protein for Mouse NF-kappa-B inhibitor alpha
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Zhixiong Pan , Jiwen Wang , Hui Tang , Liang Li , Jia Lv , Lu Xia , Chunchun Han , Feng Xu , Hua He , Hengyong Xu , Bo Kang
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Bone marrow .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
3.
"Structural analysis, expression, and chromosomal localization of the mouse ikba gene."
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Poujol D.
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Grosgeorge J.
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Carle G.F.
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Messer G.
Immunogenetics49:395-403(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-314
strain :
129/Sv .
tissue :
Liver .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BTRC;PHOSPHORYLATION AT SER-32 AND SER-36;UBIQUITINATION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN A COMPLEX WITH BTRC; SKP1 AND RELA;PHOSPHORYLATION AT SER-32 AND SER-36;UBIQUITINATION AT LYS-21 AND LYS-22
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Nakayama K.
Proc. Natl. Acad. Sci. U.S.A.96:3859-3863(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN A COMPLEX WITH BTRC; SKP1 AND CUL1;PHOSPHORYLATION AT SER-32 AND SER-36;UBIQUITINATION