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Index > Protein center > Irak1bp1(Gene name) > Mouse
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  • Irak1bp1 (Gene name),
  • Interleukin-1 receptor-associated kinase 1-binding protein 1 (Protein name ),  IKBP1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Irak1bp1(Aip70;Simpl);
    Protein name:
    Interleukin-1 receptor-associated kinase 1-binding protein 1(IRAK1-binding protein 1);
    Alternative:
    PLK-interacting protein;ActA-binding protein 70;Signaling molecule that associates with the mouse pelle-like kinase(SIMPL);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1. May interact with Listeria monocytogenes actA.
    Function:
    Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    259
    Sequence:
    50:
    MSLQPAPASR | VFMELVPWAD | RGRENHPISA | AEAQPIGRRP | HVAEAHPGAR | 
    100:
    EVHVSGAAEV | SASPDRALVT | VRVSSTKEVS | AEAKKSVCRR | LDYITQSLQQ | 
    150:
    QGFQAENVTV | TKNIRRVENA | YHMEAEVCIT | FTEFGKMQNI | CNFLVEKLDS | 
    200:
    SVVISPPEFY | HTPGSVENLR | RQACLVAVEN | AWRKAQEVCD | LVGQTLGKPL | 
    250:
    LIKEEETKDW | EGQTDDHQLS | RLPGTLTVQQ | KIKSATIHAA | SKVFITFEVK | 
    259:
    GKEKKKKHL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse IRAK1-binding protein 1
    ELISA Kit for Mouse IRAK1-binding protein 1
    CLIA Kit for Mouse IRAK1-binding protein 1
    CLIA Kit for Mouse IRAK1-binding protein 1
    Polyclonal Antibody for Mouse IRAK1-binding protein 1
    Polyclonal Antibody for Mouse IRAK1-binding protein 1
    Monoclonal Antibody for Mouse IRAK1-binding protein 1
    Monoclonal Antibody for Mouse IRAK1-binding protein 1
    Protein for Mouse IRAK1-binding protein 1
    Protein for Mouse IRAK1-binding protein 1

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity."
      Vig E. , Green M. , Liu Y. , Yu K.-Y. , Kwon H.-J. , Tian J. , Goebl M.G. , Harrington M.A.
      J. Biol. Chem.276:7859-7866(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH IRAK1;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Corpora quadrigemina.
      tissue: Embryo.
      tissue: Testis.
      tissue: Tongue.
      tissue: Wolffian duct.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    4. 4.
      "LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system co-localizes with intracellular Listeria monocytogenes."
      Pfeuffer T. , Goebel W. , Laubinger J. , Bachmann M. , Kuhn M.
      Cell. Microbiol.2:101-114(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-259;POSSIBLE INTERACTION WITH LISTERIA MONOCYTOGENES ACTA
      strain: CD-1.
    5. 5.
      "Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL."
      Kwon H.-J. , Breese E.H. , Vig-Varga E. , Luo Y. , Lee Y. , Goebl M.G. , Harrington M.A.
      Mol. Cell. Biol.24:9317-9326(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;NUCLEAR LOCALIZATION SIGNAL;INTERACTION WITH RELA
    6. 6.
      "The disordered amino-terminus of SIMPL interacts with members of the 70-kDa heat-shock protein family."
      Haag Breese E. , Uversky V.N. , Georgiadis M.M. , Harrington M.A.
      DNA Cell Biol.25:704-714(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HSPA8 AND HSPA1
    7. 7.
      "Phosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription."
      Luo Y. , Kwon H.-J. , Montano S. , Georgiadis M. , Goebl M.G. , Harrington M.A.
      Am. J. Physiol.292:C1013-C1023(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-55; SER-61; SER-63; SER-234; THR-236; SER-241 AND THR-246
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