Gene name:
IKZF3 (ZNFN1A3) ;
Protein name:
Zinc finger protein Aiolos ;
Alternative:
Ikaros family zinc finger protein 3 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L; this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A.
Function:
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Subcellular Location:
Nucleus
Cytoplasm
Protein Attributes:
50:
MEDIKPNVEL | KSTQEQSVPT | EGSELLNDYD | LTKAHETENV | DGTEGPANED |
100:
EDIGDDSMKV | KDEYSERDEN | VLKPEPMGNA | EEPEIPYSYS | REYNEYENIK |
150:
LERHVVSYDS | SRPTSGKMNC | DVCGLSCISF | NVLMVHKRSH | TGERPFQCNQ |
200:
CGASFTQKGN | LLRHIKLHTG | EKPFKCHLCN | YACQRRDALT | GHLRTHSVEK |
250:
PYKCEFCGRS | YKQRSSLEEH | KERCRTFLQS | TDLGETASVE | ARHIKAEMGS |
300:
ERALVLDRLA | SNVAKRKSSM | PQKFIGEKRH | CFDVSYNPSY | MYEKESEMIQ |
350:
TRMMDQAINN | AISYLGAEAL | RPLVQTPPAP | TSEMVPVISS | MYPIALTRAE |
400:
MPNGAPQELE | KKNIHLPEKS | LPSERGLSPT | NSGHDSTDTD | SNHEERQNHI |
450:
YQQNPMVPPR | ARNGMPLLKE | GPRSYDLLKP | PPICPRDSIK | VINKEGEVTD |
500:
VYRCDHCRVL | FLDYVMFTIH | MGCHGFRDPF | ECNMCGYRSH | DRYEFSSHIA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Bovine Zinc finger protein Aiolos
ELISA Kit for Bovine Zinc finger protein Aiolos
ELISA Kit for Bovine Zinc finger protein Aiolos
CLIA Kit for Bovine Zinc finger protein Aiolos
CLIA Kit for Bovine Zinc finger protein Aiolos
CLIA Kit for Bovine Zinc finger protein Aiolos
Polyclonal Antibody for Bovine Zinc finger protein Aiolos
Polyclonal Antibody for Bovine Zinc finger protein Aiolos
Polyclonal Antibody for Bovine Zinc finger protein Aiolos
Monoclonal Antibody for Bovine Zinc finger protein Aiolos
Monoclonal Antibody for Bovine Zinc finger protein Aiolos
Monoclonal Antibody for Bovine Zinc finger protein Aiolos
Protein for Bovine Zinc finger protein Aiolos
Protein for Bovine Zinc finger protein Aiolos
Protein for Bovine Zinc finger protein Aiolos
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Thymus .