Gene name:
Il1r1 (Il-1r1;Il1ra) ;
Protein name:
Interleukin-1 receptor type 1 (IL-1R-1;IL-1RT-1;IL-1RT1) ;
Alternative:
Interleukin-1 receptor alpha (IL-1R-alpha) ;CD121 antigen-like family member A ;p80 ;Interleukin-1 receptor type I ;
CD:
CD121a ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MENMKVLLGL | ICLMVPLLSL | EIDVCTEYPN | QIVLFLSVNE | IDIRKCPLTP |
100:
NKMHGDTIIW | YKNDSKTPIS | ADRDSRIHQQ | NEHLWFVPAK | VEDSGYYYCI |
150:
VRNSTYCLKT | KVTVTVLEND | PGLCYSTQAT | FPQRLHIAGD | GSLVCPYVSY |
200:
FKDENNELPE | VQWYKNCKPL | LLDNVSFFGV | KDKLLVRNVA | EEHRGDYICR |
250:
MSYTFRGKQY | PVTRVIQFIT | IDENKRDRPV | ILSPRNETIE | ADPGSMIQLI |
300:
CNVTGQFSDL | VYWKWNGSEI | EWNDPFLAED | YQFVEHPSTK | RKYTLITTLN |
350:
ISEVKSQFYR | YPFICVVKNT | NIFESAHVQL | IYPVPDFKNY | LIGGFIILTA |
400:
TIVCCVCIYK | VFKVDIVLWY | RDSCSGFLPS | KASDGKTYDA | YILYPKTLGE |
450:
GSFSDLDTFV | FKLLPEVLEG | QFGYKLFIYG | RDDYVGEDTI | EVTNENVKKS |
500:
RRLIIILVRD | MGGFSWLGQS | SEEQIAIYNA | LIQEGIKIVL | LELEKIQDYE |
550:
KMPDSIQFIK | QKHGVICWSG | DFQERPQSAK | TRFWKNLRYQ | MPAQRRSPLS |
576:
KHRLLTLDPV | RDTKEKLPAA | THLPLG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse IL-1R-1
ELISA Kit for Mouse IL-1R-1
ELISA Kit for Mouse IL-1R-1
CLIA Kit for Mouse IL-1R-1
CLIA Kit for Mouse IL-1R-1
CLIA Kit for Mouse IL-1R-1
Polyclonal Antibody for Mouse IL-1R-1
Polyclonal Antibody for Mouse IL-1R-1
Polyclonal Antibody for Mouse IL-1R-1
Monoclonal Antibody for Mouse IL-1R-1
Monoclonal Antibody for Mouse IL-1R-1
Monoclonal Antibody for Mouse IL-1R-1
Protein for Mouse IL-1R-1
Protein for Mouse IL-1R-1
Protein for Mouse IL-1R-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Chi C, Jiang X J, Su L, et al.
References
1.
"cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily."
Sims J.E.
,
March C.J.
,
Cosman D.
,
Widmer M.B.
,
McDonald H.R.
,
McMahan C.J.
,
Grubin C.E.
,
Wignall J.M.
,
Jackson J.L.
,
Call S.M.
,
Friend D.
,
Alpert A.R.
,
Gillis S.
,
Urdal D.L.
,
Dower S.K.
Science241:585-589(1988)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 20-45
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-556
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IL1RAP
4.
"Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor."
Burns K.
,
Clatworthy J.
,
Martin L.
,
Martinon F.
,
Plumpton C.
,
Maschera B.
,
Lewis A.
,
Ray K.
,
Tschopp J.
,
Volpe F.
Nat. Cell Biol.2:346-351(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TOLLIP; MYD88 AND IRAK1
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : 3D-STRUCTURE MODELING OF 25-334