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Index > Protein center > IL1R2(Gene name) > Human
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  • IL1R2 (Gene name),
  • Interleukin-1 receptor type 2 (Protein name ),  IL1R2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IL1R2(IL1RB);
    Protein name:
    Interleukin-1 receptor type 2(IL-1R-2;IL-1RT-2;IL-1RT2);
    Alternative:
    CDw121b;CD121 antigen-like family member B;Interleukin-1 receptor type II(IL-1R-beta);Interleukin-1 receptor beta(IL-1R-beta);Interleukin-1 receptor type II;
    CD:
    CD121b;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    The signaling-competent complex is a heterodimer of IL1R2 and IL1RAP bound to IL1B.
    Function:
    Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1ra).
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    398
    Sequence:
    50:
    MLRLYVLVMG | VSAFTLQPAA | HTGAARSCRF | RGRHYKREFR | LEGEPVALRC | 
    100:
    PQVPYWLWAS | VSPRINLTWH | KNDSARTVPG | EEETRMWAQD | GALWLLPALQ | 
    150:
    EDSGTYVCTT | RNASYCDKMS | IELRVFENTD | AFLPFISYPQ | ILTLSTSGVL | 
    200:
    VCPDLSEFTR | DKTDVKIQWY | KDSLLLDKDN | EKFLSVRGTT | HLLVHDVALE | 
    250:
    DAGYYRCVLT | FAHEGQQYNI | TRSIELRIKK | KKEETIPVII | SPLKTISASL | 
    300:
    GSRLTIPCKV | FLGTGTPLTT | MLWWTANDTH | IESAYPGGRV | TEGPRQEYSE | 
    350:
    NNENYIEVPL | IFDPVTREDL | HMDFKCVVHN | TLSFQTLRTT | VKEASSTFSW | 
    398:
    GIVLAPLSLA | FLVLGGIWMH | RRCKHRTGKA | DGLTVLWPHH | QDFQSYPK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    Pfam:
    SMR:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-1R-2
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    ELISA Kit for Human IL-1R-2
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    CLIA Kit for Human IL-1R-2
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    CLIA Kit for Human IL-1R-2
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    U0066r
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    CLIA Kit for Human IL-1R-2
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    U0066m
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    Packing:
    96T
    Polyclonal Antibody for Human IL-1R-2
    Cat.:
    P0066Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-1R-2
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    P0066Rb-r
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    Polyclonal Antibody for Human IL-1R-2
    Cat.:
    P0066Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IL-1R-2
    Monoclonal Antibody for Human IL-1R-2
    Monoclonal Antibody for Human IL-1R-2
    Protein for Human IL-1R-2
    Protein for Human IL-1R-2
    Protein for Human IL-1R-2

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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
      tissue: B-cell.
    2. 2.
      "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA."
      Liu C. , Hart R.P. , Liu X.J. , Clevenger W. , Maki R.A. , Souza E.B.
      J. Biol. Chem.271:20965-20972(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);IL1B-BINDING;SUBCELLULAR LOCATION (ISOFORM SHORT)
    3. 3.
      "Complete nucleotide sequence and expression of the human interleukin-1 receptor type II in human gingival fibroblasts."
      Chou H.-H. , Takashiba T. , Takigawa M. , Maeda H. , Asahara Y. , Nishimura F. , Arai H. , Murayama Y.
      Submitted (1996-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2002-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-181 AND LYS-292
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      tissue: Ovary.
    8. 8.
      "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses."
      Giri J.G. , Wells J. , Dower S.K. , McCall C.E. , Guzman R.N. , Slack J. , Bird T.A. , Shanebeck K. , Grabstein K.H. , Sims J.E. , Alderson M.R.
      J. Immunol.153:5802-5809(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PROTEOLYTIC PROCESSING;LIGAND-BINDING
    9. 9.
      "Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist."
      Symons J.A. , Young P.R. , Duff G.W.
      Proc. Natl. Acad. Sci. U.S.A.92:1714-1718(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIGAND-BINDING
    10. 10.
      "Role of metalloproteases in the release of the IL-1 type II decoy receptor."
      Orlando S. , Sironi M. , Bianchi G. , Drummond A.H. , Boraschi D. , Yabes D. , Mantovani A.
      J. Biol. Chem.272:31764-31769(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    11. 11.
      "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness."
      Lang D. , Knop J. , Wesche H. , Raffetseder U. , Kurrle R. , Boraschi D. , Martin M.U.
      J. Immunol.161:6871-6877(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IL1RAP
    12. 12.
      "The membrane form of the type II IL-1 receptor accounts for inhibitory function."
      Neumann D. , Kollewe C. , Martin M.U. , Boraschi D.
      J. Immunol.165:3350-3357(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS DECOY RECEPTOR
    13. 13.
      "The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action."
      Smith D.E. , Hanna R. , Friend D. , Moore H. , Chen H. , Farese A.M. , MacVittie T.J. , Virca G.D. , Sims J.E.
      Immunity18:87-96(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS DECOY RECEPTOR
    14. 14.
      "Structural insights into the assembly and activation of IL-1beta with its receptors."
      Wang D. , Zhang S. , Li L. , Liu X. , Mei K. , Wang X.
      Nat. Immunol.11:905-911(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 14-343 IN COMPLEX WITH IL1RAP AND IL1B;SUBUNIT;DISULFIDE BONDS;GLYCOSYLATION AT ASN-112 AND ASN-219
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