Protein name:
Interleukin-1 receptor type 2 (IL-1R-2;IL-1RT-2;IL-1RT2) ;
Alternative:
CDw121b ;CD121 antigen-like family member B ;Interleukin-1 receptor type II (IL-1R-beta) ;Interleukin-1 receptor beta (IL-1R-beta) ;Interleukin-1 receptor type II ;
CD:
CD121b ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
The signaling-competent complex is a heterodimer of IL1R2 and IL1RAP bound to IL1B.
Function:
Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1ra).
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MLRLYVLVMG | VSAFTLQPAA | HTGAARSCRF | RGRHYKREFR | LEGEPVALRC |
100:
PQVPYWLWAS | VSPRINLTWH | KNDSARTVPG | EEETRMWAQD | GALWLLPALQ |
150:
EDSGTYVCTT | RNASYCDKMS | IELRVFENTD | AFLPFISYPQ | ILTLSTSGVL |
200:
VCPDLSEFTR | DKTDVKIQWY | KDSLLLDKDN | EKFLSVRGTT | HLLVHDVALE |
250:
DAGYYRCVLT | FAHEGQQYNI | TRSIELRIKK | KKEETIPVII | SPLKTISASL |
300:
GSRLTIPCKV | FLGTGTPLTT | MLWWTANDTH | IESAYPGGRV | TEGPRQEYSE |
350:
NNENYIEVPL | IFDPVTREDL | HMDFKCVVHN | TLSFQTLRTT | VKEASSTFSW |
398:
GIVLAPLSLA | FLVLGGIWMH | RRCKHRTGKA | DGLTVLWPHH | QDFQSYPK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human IL-1R-2
ELISA Kit for Human IL-1R-2
ELISA Kit for Human IL-1R-2
CLIA Kit for Human IL-1R-2
CLIA Kit for Human IL-1R-2
CLIA Kit for Human IL-1R-2
Polyclonal Antibody for Human IL-1R-2
Polyclonal Antibody for Human IL-1R-2
Polyclonal Antibody for Human IL-1R-2
Monoclonal Antibody for Human IL-1R-2
Monoclonal Antibody for Human IL-1R-2
Monoclonal Antibody for Human IL-1R-2
Protein for Human IL-1R-2
Protein for Human IL-1R-2
Protein for Human IL-1R-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types."
McMahan C.J.
,
Slack J.L.
,
Mosley B.
,
Cosman D.
,
Lupton S.D.
,
Brunton L.L.
,
Grubin C.E.
,
Wignall J.M.
,
Jenkins N.A.
,
Brannan C.I.
,
Copeland N.G.
,
Huebner K.
,
Croce C.M.
,
Cannizzarro L.A.
,
Benjamin D.
,
Dower S.K.
,
Spriggs M.K.
,
Sims J.E.
EMBO J.10:2821-2832(1991)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
tissue :
B-cell .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);IL1B-BINDING;SUBCELLULAR LOCATION (ISOFORM SHORT)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-181 AND LYS-292
5.
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W.
,
Graves T.A.
,
Fulton R.S.
,
Fulton L.A.
,
Pepin K.H.
,
Minx P.
,
Wagner-McPherson C.
,
Layman D.
,
Wylie K.
,
Sekhon M.
,
Becker M.C.
,
Fewell G.A.
,
Delehaunty K.D.
,
Miner T.L.
,
Nash W.E.
,
Kremitzki C.
,
Oddy L.
,
Du H.
,
Sun H.
,
Bradshaw-Cordum H.
,
Ali J.
,
Carter J.
,
Cordes M.
,
Harris A.
,
Isak A.
,
van Brunt A.
,
Nguyen C.
,
Du F.
,
Courtney L.
,
Kalicki J.
,
Ozersky P.
,
Abbott S.
,
Armstrong J.
,
Belter E.A.
,
Caruso L.
,
Cedroni M.
,
Cotton M.
,
Davidson T.
,
Desai A.
,
Elliott G.
,
Erb T.
,
Fronick C.
,
Gaige T.
,
Haakenson W.
,
Haglund K.
,
Holmes A.
,
Harkins R.
,
Kim K.
,
Kruchowski S.S.
,
Strong C.M.
,
Grewal N.
,
Goyea E.
,
Hou S.
,
Levy A.
,
Martinka S.
,
Mead K.
,
McLellan M.D.
,
Meyer R.
,
Randall-Maher J.
,
Tomlinson C.
,
Dauphin-Kohlberg S.
,
Kozlowicz-Reilly A.
,
Shah N.
,
Swearengen-Shahid S.
,
Snider J.
,
Strong J.T.
,
Thompson J.
,
Yoakum M.
,
Leonard S.
,
Pearman C.
,
Trani L.
,
Radionenko M.
,
Waligorski J.E.
,
Wang C.
,
Rock S.M.
,
Tin-Wollam A.-M.
,
Maupin R.
,
Latreille P.
,
Wendl M.C.
,
Yang S.-P.
,
Pohl C.
,
Wallis J.W.
,
Spieth J.
,
Bieri T.A.
,
Berkowicz N.
,
Nelson J.O.
,
Osborne J.
,
Ding L.
,
Meyer R.
,
Sabo A.
,
Shotland Y.
,
Sinha P.
,
Wohldmann P.E.
,
Cook L.L.
,
Hickenbotham M.T.
,
Eldred J.
,
Williams D.
,
Jones T.A.
,
She X.
,
Ciccarelli F.D.
,
Izaurralde E.
,
Taylor J.
,
Schmutz J.
,
Myers R.M.
,
Cox D.R.
,
Huang X.
,
McPherson J.D.
,
Mardis E.R.
,
Clifton S.W.
,
Warren W.C.
,
Chinwalla A.T.
,
Eddy S.R.
,
Marra M.A.
,
Ovcharenko I.
,
Furey T.S.
,
Miller W.
,
Eichler E.E.
,
Bork P.
,
Suyama M.
,
Torrents D.
,
Waterston R.H.
,
Wilson R.K.
more...
Nature434:724-731(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
tissue :
Ovary .
8.
"Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses."
Giri J.G.
,
Wells J.
,
Dower S.K.
,
McCall C.E.
,
Guzman R.N.
,
Slack J.
,
Bird T.A.
,
Shanebeck K.
,
Grabstein K.H.
,
Sims J.E.
,
Alderson M.R.
J. Immunol.153:5802-5809(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PROTEOLYTIC PROCESSING;LIGAND-BINDING
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : LIGAND-BINDING
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH IL1RAP
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS DECOY RECEPTOR
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS DECOY RECEPTOR
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 14-343 IN COMPLEX WITH IL1RAP AND IL1B;SUBUNIT;DISULFIDE BONDS;GLYCOSYLATION AT ASN-112 AND ASN-219