Gene name:
IL37(FIL1Z;IL1F7;IL1H4;IL1RP1);
Protein name:
Interleukin-37;
Alternative:
IL-1X;FIL1 zeta;Interleukin-1 homolog 4(IL-1H;IL-1H4);Interleukin-1 family member 7(IL-1F7);Interleukin-1-related protein(IL-1RP1);Interleukin-1 zeta(IL-1 zeta);Interleukin-23(IL-37);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with SMAD3. Binds IL18R1, but not to IL1R1, with lower affinity than IL18, and does not seem to act as a receptor antagonist for IL18.
Function:
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Subcellular Location:
Cytoplasm
cytosol
Nucleus
Secreted
Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
Protein Attributes:
50:
MSFVGENSGV | KMGSEDWEKD | EPQCCLEDPA | GSPLEPGPSL | PTMNFVHTSP |
100:
KVKNLNPKKF | SIHDQDHKVL | VLDSGNLIAV | PDKNYIRPEI | FFALASSLSS |
150:
ASAEKGSPIL | LGVSKGEFCL | YCDKDKGQSH | PSLQLKKEKL | MKLAAQKESA |
200:
RRPFIFYRAQ | VGSWNMLESA | AHPGWFICTS | CNCNEPVGVT | DKFENRKHIE |
218:
FSFQPVCKAE | MSPSEVSD
Vaild Sequence:
Related Databases
Uniprot:
