Protein name:
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta;IL-6R subunit beta;IL-6R-beta;IL-6RB) ;
Alternative:
Membrane glycoprotein 130 (gp130) ;Interleukin-6 signal transducer ;Oncostatin-M receptor subunit alpha ;
CD:
CD130 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of a hexamer of two molecules each of IL6, IL6R and IL6ST (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Interacts with INPP5D/SHIP1.
Function:
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MSAPRIWLAQ | ALLFFLTTES | IGQLLEPCGY | IYPEFPVVQR | GSNFTAICVL |
100:
KEACLQHYYV | NASYIVWKTN | HAAVPREQVT | VINRTTSSVT | FTDVVLPSVQ |
150:
LTCNILSFGQ | IEQNVYGVTM | LSGFPPDKPT | NLTCIVNEGK | NMLCQWDPGR |
200:
ETYLETNYTL | KSEWATEKFP | DCQSKHGTSC | MVSYMPTYYV | NIEVWVEAEN |
250:
ALGKVSSESI | NFDPVDKVKP | TPPYNLSVTN | SEELSSILKL | SWVSSGLGGL |
300:
LDLKSDIQYR | TKDASTWIQV | PLEDTMSPRT | SFTVQDLKPF | TEYVFRIRSI |
350:
KDSGKGYWSD | WSEEASGTTY | EDRPSRPPSF | WYKTNPSHGQ | EYRSVRLIWK |
400:
ALPLSEANGK | ILDYEVILTQ | SKSVSQTYTV | TGTELTVNLT | NDRYVASLAA |
450:
RNKVGKSAAA | VLTIPSPHVT | AAYSVVNLKA | FPKDNLLWVE | WTPPPKPVSK |
500:
YILEWCVLSE | NAPCVEDWQQ | EDATVNRTHL | RGRLLESKCY | QITVTPVFAT |
550:
GPGGSESLKA | YLKQAAPARG | PTVRTKKVGK | NEAVLAWDQI | PVDDQNGFIR |
600:
NYSISYRTSV | GKEMVVHVDS | SHTEYTLSSL | SSDTLYMVRM | AAYTDEGGKD |
650:
GPEFTFTTPK | FAQGEIEAIV | VPVCLAFLLT | TLLGVLFCFN | KRDLIKKHIW |
700:
PNVPDPSKSH | IAQWSPHTPP | RHNFNSKDQM | YSDGNFTDVS | VVEIEANNKK |
750:
PCPDDLKSVD | LFKKEKVSTE | GHSSGIGGSS | CMSSSRPSIS | SNEENESAQS |
800:
TASTVEYSTV | VHSGYRHQVP | SVQVFSRSES | TQPLLDSEER | PEDLQLVDSV |
850:
DGGDEILPRQ | PYFKQNCSQP | EACPEISHFE | RSNQVLSGNE | EDFVRLKQQQ |
900:
VSDHISQPYG | SEQRRLFQEG | STADALGTGA | DGQMERFESV | GMETTIDEEI |
917:
PKSYLPQTVR | QGGYMPQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse IL-6 receptor subunit beta
ELISA Kit for Mouse IL-6 receptor subunit beta
ELISA Kit for Mouse IL-6 receptor subunit beta
CLIA Kit for Mouse IL-6 receptor subunit beta
CLIA Kit for Mouse IL-6 receptor subunit beta
CLIA Kit for Mouse IL-6 receptor subunit beta
Polyclonal Antibody for Mouse IL-6 receptor subunit beta
Polyclonal Antibody for Mouse IL-6 receptor subunit beta
Polyclonal Antibody for Mouse IL-6 receptor subunit beta
Monoclonal Antibody for Mouse IL-6 receptor subunit beta
Monoclonal Antibody for Mouse IL-6 receptor subunit beta
Monoclonal Antibody for Mouse IL-6 receptor subunit beta
Protein for Mouse IL-6 receptor subunit beta
Protein for Mouse IL-6 receptor subunit beta
Protein for Mouse IL-6 receptor subunit beta
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
ICR .
tissue :
Macrophage .
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
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Hillier L.W.
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Zody M.C.
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Goldstein S.
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She X.
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Bult C.J.
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Agarwala R.
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Cherry J.L.
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DiCuccio M.
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Hlavina W.
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Kapustin Y.
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Meric P.
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Maglott D.
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Birtle Z.
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Marques A.C.
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Graves T.
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Zhou S.
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Teague B.
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Potamousis K.
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Churas C.
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Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
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more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBUNIT
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH INPP5D
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-225