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Index > Protein center > Il6st(Gene name) > Rat
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  • Il6st (Gene name),
  • Interleukin-6 receptor subunit beta (Protein name ),  IL6RB_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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    • Gene name:
    Il6st;
    Protein name:
    Interleukin-6 receptor subunit beta(IL-6 receptor subunit beta;IL-6R subunit beta;IL-6R-beta;IL-6RB);
    Alternative:
    Membrane glycoprotein 130(gp130);Interleukin-6 signal transducer;Oncostatin-M receptor subunit alpha;
    CD:
    CD130;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Component of a hexamer of two molecules each of IL6, IL6R and IL6ST (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Interacts with INPP5D/SHIP1.
    Function:
    Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    918
    Sequence:
    50:
    MSALRIWLMQ | ALLIFLTTES | IGQLVEPCGY | IYPEFPVVQR | GSNFTATCVL | 
    100:
    KEKCLQVYSV | NATYIVWKTN | HVAVPKEQVT | VINRTASSVT | FTDVVFQNVQ | 
    150:
    LTCNILSFGQ | IEQNVYGITI | LSGYPPDIPT | NLSCIVNEGK | NMLCQLDPGR | 
    200:
    ETYLETNYTL | KSEWATEKFP | DCRTKHGTSS | CMMGYTPIYF | VNIEVWVEAE | 
    250:
    NALGNVSSEP | INFDPVDKVK | PSPPHNLSVT | NSEELSSILK | LAWVNSGLDS | 
    300:
    ILRLKSDIQY | RTKDASTWIQ | VPLEDTVSPR | TSFTVQDLKP | FTEYVFRIRS | 
    350:
    IKENGKGYWS | DWSEEASGTT | YEDRPSKAPS | FWYKVNANHP | QEYRSARLIW | 
    400:
    KTLPLSEANG | KILDYEVVLT | QSKSVSQTYT | VNGTELIVNL | TNNRYVASLA | 
    450:
    ARNVVGKSPA | TVLTIPGSHF | KASHPVVDLK | AFPKDNLLWV | EWTPPSKPVN | 
    500:
    KYILEWCVLS | ENSPCIPDWQ | QEDGTVNRTH | LRGSLLESKC | YLITVTPVFP | 
    550:
    GGPGSPESMK | AYLKQAAPSK | GPTVRTKKVG | KNEAVLEWDH | LPVDVQNGFI | 
    600:
    RNYSISYRTS | VGKEMVVRVD | SSHTEYTLSS | LSSDTLYMVH | MAAYTEEGGK | 
    650:
    DGPEFTFTTL | KFAQGEIEAI | VVPVCLAFLL | TTLLGVLFCF | NKRDLIKKHI | 
    700:
    WPNVPDPSKS | HIAQWSPHTP | PRHNFNSKDQ | MYSDANFTDV | SVVEIEANNK | 
    750:
    KPCPDDLKSL | DLFKKEKIST | EGHSSGIGGS | SCMSSSRPSI | SSSEENESAQ | 
    800:
    STASTVQYST | VVHSGYRHQV | PSVQVFSRSE | STQPLLDSEE | RPEDLQLVDS | 
    850:
    VDSGDEILPR | QQYFKQSCSQ | PGASPDVSHF | GRSSQVPSGS | EEDFVRLKQQ | 
    900:
    QVSDHISEPY | GSEQRRLFQE | GSVADALGTG | TDGQIERFES | VGMETAMDED | 
    918:
    ISKSYLPQTV | RQGGYMPQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Rn.12138
    STRING:
    10116.ENSRNOP00000047366
    String:
    P40190
    Pfam:
    PF00041
    SMR:
    P40190
    Uniprot:
    P40190
     
    FOR
    ELISA Kit for Rat IL-6 receptor subunit beta
    Cat.:
    E0046h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat IL-6 receptor subunit beta
    Cat.:
    E0046m
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    96T
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    ELISA Kit for Rat IL-6 receptor subunit beta
    Cat.:
    E0046r
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    Packing:
    96T
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    CLIA Kit for Rat IL-6 receptor subunit beta
    Cat.:
    U0046r
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    Looking for manual.
    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Rat IL-6 receptor subunit beta
    Cat.:
    U0046m
    Price:
    Please sign in first.
    Manual:
    Looking for manual.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat IL-6 receptor subunit beta
    Cat.:
    U0046h
    Price:
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    MSDS:
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    Packing:
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    Polyclonal Antibody for Rat IL-6 receptor subunit beta
    Cat.:
    P0046Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat IL-6 receptor subunit beta
    Cat.:
    P0046Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat IL-6 receptor subunit beta
    Cat.:
    P0046Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat IL-6 receptor subunit beta
    Monoclonal Antibody for Rat IL-6 receptor subunit beta
    Monoclonal Antibody for Rat IL-6 receptor subunit beta
    Protein for Rat IL-6 receptor subunit beta
    Protein for Rat IL-6 receptor subunit beta
    Protein for Rat IL-6 receptor subunit beta

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    References
    1. 1.
      "Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule, gp130."
      Wang Y. , Nesbitt J.E. , Fuentes N.L. , Fuller G.M.
      Genomics14:666-672(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
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