Protein name:
Interleukin enhancer-binding factor 3 ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with FUS and SMN proteins and with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346 (By similarity). Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with EIF2C1 and EIF2C2.
Function:
May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). Can regulate protein arginine N-methyltransferase 1 activity.
Subcellular Location:
Nucleus
nucleolus
Cytoplasm
Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein Attributes:
50:
MRPMRIFVND | DRHVMAKHSS | VYPTQEELEA | VQNMVSHTER | ALKAVSDWID |
100:
EQEKGNSELS | EAENMDTPPD | DESKEGAGEQ | KAEHMTRTLR | GVMRVGLVAK |
150:
GLLLKGDLDL | ELVLLCKEKP | TTALLDKVAD | NLAIQLTTVT | EDKYEILQSV |
200:
DDAAIVIKNT | KEPPLSLTIH | LTSPVVREEM | EKVLAGETLS | VNDPPDVLDR |
250:
QKCLAALASL | RHAKWFQARA | NGLKSCVIVI | RVLRDLCTRV | PTWGPLRGWP |
300:
LELLCEKSIG | TANRPMGAGE | ALRRVLECLA | SGIVMPDGSG | IYDPCEKEAT |
350:
DAIGHLDRQQ | REDITQSAQH | ALRLAAFGQL | HKVLGMDPLP | SKMPKKPKNE |
400:
NPVDYTVQIP | PSTTYAITPM | KRPMEEDGEE | KSPSKKKKKI | QKKEEKAEPP |
450:
QAMNALMRLN | QLKPGLQYKL | ISQTGPVHAP | IFTMSVEVDG | STFEASGPSK |
500:
KTAKLHVAVK | VLQDMGLPTG | AEGRDSSKGE | DSAEESDGKP | AVVAPPPVVE |
550:
AVSNPSSVFP | SDATTEQGPI | LTKHGKNPVM | ELNEKRRGLK | YELISETGGS |
600:
HDKRFVMEVE | VDGQKFQGAG | SNKKVAKAYA | ALAALEKLFP | DAPLALEANK |
650:
KKRAPVPVRG | GPKFAAKPHN | PGFGMGGPMH | NEAPPPPNIR | GRGRGGNIRG |
700:
RGRGRGFGGT | NHGGGYMNAG | AGYGSYGYSS | NSATAGYSQF | YSNGGHYGNA |
750:
GGGGSGGGGG | SSSYSSYYQG | DSYNSPVPPK | HAGKKPLHGG | QQKPSYSSGY |
800:
QSHQGQQQPY | NQSQYSSYGT | PQGKQKGYGH | GQGSYSSYSN | SYNSPGGGGG |
850:
SDYSYDSKFN | YSGSGGRSGG | NSYGSSGSSY | NTGSHGGYGA | GSGGSSSYQG |
897:
KQGGYSSQSN | YSSPGSSQSY | SGPASSYQSS | QGGYSRNTEH | SMNYQYR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Rat Interleukin enhancer-binding factor 3
ELISA Kit for Rat Interleukin enhancer-binding factor 3
ELISA Kit for Rat Interleukin enhancer-binding factor 3
CLIA Kit for Rat Interleukin enhancer-binding factor 3
CLIA Kit for Rat Interleukin enhancer-binding factor 3
CLIA Kit for Rat Interleukin enhancer-binding factor 3
Polyclonal Antibody for Rat Interleukin enhancer-binding factor 3
Polyclonal Antibody for Rat Interleukin enhancer-binding factor 3
Polyclonal Antibody for Rat Interleukin enhancer-binding factor 3
Monoclonal Antibody for Rat Interleukin enhancer-binding factor 3
Monoclonal Antibody for Rat Interleukin enhancer-binding factor 3
Monoclonal Antibody for Rat Interleukin enhancer-binding factor 3
Protein for Rat Interleukin enhancer-binding factor 3
Protein for Rat Interleukin enhancer-binding factor 3
Protein for Rat Interleukin enhancer-binding factor 3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
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Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1)
strain :
Brown Norway .