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Index > Protein center > IMPAD1(Gene name) > Human
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  • IMPAD1 (Gene name),
  • Inositol monophosphatase 3 (Protein name ),  IMPA3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    IMPAD1(IMPA3);
    Protein name:
    Inositol monophosphatase 3(IMP 3;IMPase 3);
    Alternative:
    Inositol monophosphatase domain-containing protein 1;Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase(Golgi-resident PAP phosphatase;gPAPP);Myo-inositol monophosphatase A3;Inositol-1(or 4)-monophosphatase 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation.
    Subcellular Location:
    Golgi apparatus trans-Golgi network membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    359
    Sequence:
    50:
    MAPMGIRLSP | LGVAVFCLLG | LGVLYHLYSG | FLAGRFSLFG | LGGEPGGGAA | 
    100:
    GPAAAADGGT | VDLREMLAVS | VLAAVRGGDE | VRRVRESNVL | HEKSKGKTRE | 
    150:
    GAEDKMTSGD | VLSNRKMFYL | LKTAFPSVQI | NTEEHVDAAD | QEVILWDHKI | 
    200:
    PEDILKEVTT | PKEVPAESVT | VWIDPLDATQ | EYTEDLRKYV | TTMVCVAVNG | 
    250:
    KPMLGVIHKP | FSEYTAWAMV | DGGSNVKARS | SYNEKTPRIV | VSRSHSGMVK | 
    300:
    QVALQTFGNQ | TTIIPAGGAG | YKVLALLDVP | DKSQEKADLY | IHVTYIKKWD | 
    350:
    ICAGNAILKA | LGGHMTTLSG | EEISYTGSDG | IEGGLLASIR | MNHQALVRKL | 
    359:
    PDLEKTGHK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    MIM:
    SMR:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human IMP 3
    ELISA Kit for Human IMP 3
    ELISA Kit for Human IMP 3
    ELISA Kit for Human IMP 3
    ELISA Kit for Human IMP 3
    CLIA Kit for Human IMP 3
    CLIA Kit for Human IMP 3
    CLIA Kit for Human IMP 3
    CLIA Kit for Human IMP 3
    CLIA Kit for Human IMP 3
    Polyclonal Antibody for Human IMP 3
    Polyclonal Antibody for Human IMP 3
    Polyclonal Antibody for Human IMP 3
    Polyclonal Antibody for Human IMP 3
    Polyclonal Antibody for Human IMP 3
    Monoclonal Antibody for Human IMP 3
    Monoclonal Antibody for Human IMP 3
    Monoclonal Antibody for Human IMP 3
    Monoclonal Antibody for Human IMP 3
    Monoclonal Antibody for Human IMP 3
    Protein for Human IMP 3
    Protein for Human IMP 3
    Protein for Human IMP 3
    Protein for Human IMP 3
    Protein for Human IMP 3

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and expression of human myo-inositol monophosphatase A3 cDNA (IMPA3)."
      Parthasarathy L. , Parthasarathy R.
      Submitted (2001-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
      tissue: Testis.
    4. 4.
      "A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation."
      Frederick J.P. , Tafari A.T. , Wu S.M. , Megosh L.C. , Chiou S.T. , Irving R.P. , York J.D.
      Proc. Natl. Acad. Sci. U.S.A.105:11605-11612(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;GLYCOSYLATION
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    7. 7.
      "Chondrodysplasia and abnormal joint development associated with mutations in IMPAD1, encoding the Golgi-resident nucleotide phosphatase, gPAPP."
      Vissers L.E. , Lausch E. , Unger S. , Campos-Xavier A.B. , Gilissen C. , Rossi A. , Del Rosario M. , Venselaar H. , Knoll U. , Nampoothiri S. , Nair M. , Spranger J. , Brunner H.G. , Bonafe L. , Veltman J.A. , Zabel B. , Superti-Furga A.
      Am. J. Hum. Genet.88:608-615(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CDP-GPAPP ASN-177 AND PRO-183
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