Insig1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comInsig1 ELISA Kit for Rat(Rattus norvegicus)

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Insig1 (Gene name),

Insulin-induced gene 1 protein (Protein name ), INSI1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Insig1(Cl-6);

Protein name:

Insulin-induced gene 1 protein(INSIG-1);

Alternative:

Insulin-induced growth response protein CL-6;Immediate-early protein CL-6;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139.

Function:

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

259

Sequence:

50:

100:

150:

200:

250:

259:

GVPEKPHSD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:64194

STRING:

10116.ENSRNOP00000009233

UniGene:

Rn.772

Pfam:

PF07281

String:

Q08755

Uniprot:

Q08755

FOR

ELISA Kit for Rat INSIG-1

CLIA Kit for Rat INSIG-1

Polyclonal Antibody for Rat INSIG-1

Monoclonal Antibody for Rat INSIG-1

Protein for Rat INSIG-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing."
Diamond R.H. , Du K. , Lee V.M. , Mohn K.L. , Haber B.A. , Tewari D.S. , Taub R.
J. Biol. Chem.268:15185-15192(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.

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