Gene name:
    DIO1 (ITDI1;TXDI1) ;
    
 
    Protein name:
    Type I iodothyronine deiodinase ;
    
    Alternative:
    
    DIOI ;5DI ;Type-I 5'-deiodinase ;Type 1 DI ;
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Function:
    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Endoplasmic reticulum membrane  
      Single-pass membrane protein 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MGLPQPGLWL |  KRLWVLLEVA |  VHVVVGKVLL |  ILFPDRVKRN |  ILAMGEKTGM |  
    
 
    100:
    TRNPHFSHDN |  WIPTFFSTQY |  FWFVLKVRWQ |  RLEDTTELGG |  LAPNCPVVRL |  
    
 
    150:
    SGQRCNIWEF |  MQGNRPLVLN |  FGSCTUPSFM |  FKFDQFKRLI |  EDFSSIADFL |  
    
 
    200:
    VIYIEEAHAS |  DGWAFKNNMD |  IRNHQNLQDR |  LQAAHLLLAR |  SPQCPVVVDT |  
    
 
    249:
    MQNQSSQLYA |  ALPERLYIIQ |  EGRILYKGKS |  GPWNYNPEEV |  RAVLEKLHS
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Rat
         
        
        Human
         
        
        Dog
         
        
        Pig
         
        
        Chicken
         
        
        Mouse
         
        
        Rabbit
         
        
     
    
        ELISA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Type I iodothyronine deiodinase
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) 
                    
                    
                 
             
         
            
        
            
                2.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8 AND 9) 
                    
                    
                    tissue :
                    
Liver .  
             
         
            
        
            
                3.
                
                    
                        
                            "The DNA sequence and biological annotation of human chromosome 1." 
                        
                        
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                        ,
                            
Barlow K.F. 
                        ,
                            
McLay K.E. 
                        ,
                            
Kaul R. 
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Jones M.C. 
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Phillips K. 
                        ,
                        
                        
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                        ,
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                        ,
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                        ,
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                        ,
                            Lloyd C. 
                        ,
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                        ,
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                        ,
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                        ,
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                        ,
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                        ,
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                        ,
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                        ,
                            Bagguley C.L. 
                        ,
                            Bailey J. 
                        ,
                            Beasley H. 
                        ,
                            Bethel G. 
                        ,
                            Bird C.P. 
                        ,
                            Bray-Allen S. 
                        ,
                            Brown J.Y. 
                        ,
                            Brown A.J. 
                        ,
                            Buckley D. 
                        ,
                            Burton J. 
                        ,
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                        ,
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                        ,
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                        ,
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                        ,
                            Clarke G. 
                        ,
                            Clee C. 
                        ,
                            Cobley V. 
                        ,
                            Collier R.E. 
                        ,
                            Corby N. 
                        ,
                            Coville G.J. 
                        ,
                            Davies J. 
                        ,
                            Deadman R. 
                        ,
                            Dunn M. 
                        ,
                            Earthrowl M. 
                        ,
                            Ellington A.G. 
                        ,
                            Errington H. 
                        ,
                            Frankish A. 
                        ,
                            Frankland J. 
                        ,
                            French L. 
                        ,
                            Garner P. 
                        ,
                            Garnett J. 
                        ,
                            Gay L. 
                        ,
                            Ghori M.R.J. 
                        ,
                            Gibson R. 
                        ,
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                        ,
                            Gillett W. 
                        ,
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                        ,
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                        ,
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                        ,
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                        ,
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                        ,
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                        ,
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                        ,
                            Hart E. 
                        ,
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                        ,
                            Heath P.D. 
                        ,
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                        ,
                            Holt K. 
                        ,
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                        ,
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                        ,
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                        ,
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                        ,
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                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
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                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                    
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                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5) 
                    
                    
                    tissue :
                    
Kidney .  
             
         
            
        
            
                5.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25