Protein name:
Ras GTPase-activating-like protein IQGAP1 ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6 (By similarity). In case of infection, interacts with S.typhimurium protein sseI.
Function:
Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
Subcellular Location:
Cell membrane
Protein Attributes:
50:
MSAAEEVDGL | GVVRPHYGSV | LDNERLTAEE | MDERRRQNVA | YEYLCHLEEA |
100:
KRWMEACLGE | DLPPTTELEE | GLRNGVYLAK | LGNFFSPKVV | SLKKIYDREQ |
150:
TRYKATGLHF | RHTDNVIQWL | NAMDEIGLPK | IFYPETTDIY | DRKNMPRCIY |
200:
CIHALSLYLF | KLGLAPQIQD | LYGKVDFTEE | EINNMKIELE | KYGIQMPAFS |
250:
KIGGILANEL | SVDEAALHAA | VIAINEAIDR | RVAADTFTAL | KNPNAMLVNL |
300:
EEGLAPTYQD | VLYQAKQDKM | TNAKNRTENS | DRERDVYEEL | LTQAEIQGNV |
350:
NKVNTSSALA | NISLALEQGC | AVTLLKALQS | LALGLRGLQT | QNSDWYMKQL |
400:
QSDLQQKRQS | GQTDPLQKEE | VQAGVDAANS | AAQQYQRRLA | AVAAINAAIQ |
450:
KGIAEKTVLE | LMNPEAQLPQ | VYPFAADLYQ | KELATLQQQS | PEHSLTHPEL |
500:
TVAVEMLSSV | ALINRALESG | DMTTVWKQLS | SSVTGLTNIE | EENCQRYLDE |
550:
LMKLKAQAHA | ENNAFITWND | IQACVDHVNL | VVHEEHERIL | AIGLINEALD |
600:
EGDAQKTLQA | LQIPAAKLEG | VLAEVAQHYQ | DTLIRAKREK | AQETQDESAV |
650:
LWLDEIQGGI | WQSNKDTQEA | QRFALGISAI | NEAVDSGDVG | RTLSALRSPD |
700:
VGLYGVIPEC | GETYQSDLAE | AKKKRLAAGD | NNSKWVKHWV | KGGYHYYHNL |
750:
ETQAGGWAEP | PDFVQNSVQL | SREEIQSSIS | GVTAAYNREQ | LWLANEGLIT |
800:
KLQACCRGYL | VRQEFRSRMN | FLKKQIPAIT | CIQSQWRGYK | QKKAYQDRLA |
850:
YLHSHKDEVV | KIQSLARMHQ | ARKRYRDRLQ | YFRDHINDII | KIQAFIRANK |
900:
ARDDYKTLIN | AEDPPMIVVR | KFVHLLDQSD | QDFQEELDLM | KMREEVITLI |
950:
RSNQQLENDL | NLMDIKIGLL | VKNKITLQDV | VSHSKKLTKK | NKEQLSDMMM |
1000:
INKQKGGLKA | LSKEKREKLE | AYQHLFYLLQ | TNPTYLAKLI | FQMPQNKSTK |
1050:
FMDSVIFTLY | NYASNQREEY | LLLRLFQTAL | QEEIKSKVDQ | IQEIVTGNPT |
1100:
VIKMVVSFNR | GARGQNALRQ | ILAPVVKEIM | DDKSLNIKTD | PVDIYKSWVN |
1150:
QMESQTGEAS | KLPYDVTPEQ | ALSHEEVKTR | LDNSIRNMRA | VTDKFLSAIV |
1200:
SSVDKIPYGM | RFIAKVLKDS | LHEKFPDAGE | DELLKIIGNL | LYYRYMNPAI |
1250:
VAPDAFDIID | LSAGGQLTTD | QRRNLGSIAK | MLQHAASNKM | FLGDNAHLSI |
1300:
INEYLSQSYQ | KFRRFFQLAC | DVPELQDKFN | VDEYSDLVTL | TKPVIYISIG |
1350:
EIINTHTLLL | DHQDAIAPEH | NDPIHELLDD | LGEVPTIESL | IGESCGNSND |
1400:
PNKEALAKTE | VSLTLTNKFD | VPGDENAEMD | ARTILLNTKR | LIVDVIRFQP |
1450:
GETLTEILET | PATNEQEAEH | QRAMQRRAIR | DAKTPDKMKK | SKPMKEDNNL |
1500:
SLQEKKEKIQ | TGLKKLTELG | TVDPKNRYQE | LINDIAKDIR | NQRRYRQRRK |
1550:
AELVKLQQTY | SALNSKATFY | GEQVDYYKSY | IKTCLDNLAS | KGKVSKKPRE |
1600:
MKGKKSKKIS | LKYTAARLHE | KGVLLEIEDL | QANQFKNVIF | EIGPTEEVGD |
1650:
FEVKAKFMGV | QMETFMLHYQ | DLLQLQYEGV | AVMKLFDRAK | VNVNLLIFLL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Ras GTPase-activating-like protein IQGAP1
ELISA Kit for Mouse Ras GTPase-activating-like protein IQGAP1
CLIA Kit for Mouse Ras GTPase-activating-like protein IQGAP1
CLIA Kit for Mouse Ras GTPase-activating-like protein IQGAP1
Polyclonal Antibody for Mouse Ras GTPase-activating-like protein IQGAP1
Polyclonal Antibody for Mouse Ras GTPase-activating-like protein IQGAP1
Monoclonal Antibody for Mouse Ras GTPase-activating-like protein IQGAP1
Monoclonal Antibody for Mouse Ras GTPase-activating-like protein IQGAP1
Protein for Mouse Ras GTPase-activating-like protein IQGAP1
Protein for Mouse Ras GTPase-activating-like protein IQGAP1
R&D Technical Data
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Precision
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
"Sequence of Mus musculus Cdc42 effector protein IQGAP1."
Bernards A.
Submitted (2000-03) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Pre-B cell .
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-172;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CDC42
6.
"The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migration."
McLaughlin L.M.
,
Govoni G.R.
,
Gerke C.
,
Gopinath S.
,
Peng K.
,
Laidlaw G.
,
Chien Y.H.
,
Jeong H.W.
,
Li Z.
,
Brown M.D.
,
Sacks D.B.
,
Monack D.
PLoS Pathog.5:E1000671-E1000671(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH S.TYPHIMURIUM SSEI