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Index > Protein center > Iqgap1(Gene name) > Mouse
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  • Iqgap1 (Gene name),
  • Ras GTPase-activating-like protein IQGAP1 (Protein name ),  IQGA1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Iqgap1;
    Protein name:
    Ras GTPase-activating-like protein IQGAP1;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6 (By similarity). In case of infection, interacts with S.typhimurium protein sseI.
    Function:
    Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
    Subcellular Location:
    Cell membrane
    Protein Attributes:
    Sequence length:
    1657
    Sequence:
    50:
    MSAAEEVDGL | GVVRPHYGSV | LDNERLTAEE | MDERRRQNVA | YEYLCHLEEA | 
    100:
    KRWMEACLGE | DLPPTTELEE | GLRNGVYLAK | LGNFFSPKVV | SLKKIYDREQ | 
    150:
    TRYKATGLHF | RHTDNVIQWL | NAMDEIGLPK | IFYPETTDIY | DRKNMPRCIY | 
    200:
    CIHALSLYLF | KLGLAPQIQD | LYGKVDFTEE | EINNMKIELE | KYGIQMPAFS | 
    250:
    KIGGILANEL | SVDEAALHAA | VIAINEAIDR | RVAADTFTAL | KNPNAMLVNL | 
    300:
    EEGLAPTYQD | VLYQAKQDKM | TNAKNRTENS | DRERDVYEEL | LTQAEIQGNV | 
    350:
    NKVNTSSALA | NISLALEQGC | AVTLLKALQS | LALGLRGLQT | QNSDWYMKQL | 
    400:
    QSDLQQKRQS | GQTDPLQKEE | VQAGVDAANS | AAQQYQRRLA | AVAAINAAIQ | 
    450:
    KGIAEKTVLE | LMNPEAQLPQ | VYPFAADLYQ | KELATLQQQS | PEHSLTHPEL | 
    500:
    TVAVEMLSSV | ALINRALESG | DMTTVWKQLS | SSVTGLTNIE | EENCQRYLDE | 
    550:
    LMKLKAQAHA | ENNAFITWND | IQACVDHVNL | VVHEEHERIL | AIGLINEALD | 
    600:
    EGDAQKTLQA | LQIPAAKLEG | VLAEVAQHYQ | DTLIRAKREK | AQETQDESAV | 
    650:
    LWLDEIQGGI | WQSNKDTQEA | QRFALGISAI | NEAVDSGDVG | RTLSALRSPD | 
    700:
    VGLYGVIPEC | GETYQSDLAE | AKKKRLAAGD | NNSKWVKHWV | KGGYHYYHNL | 
    750:
    ETQAGGWAEP | PDFVQNSVQL | SREEIQSSIS | GVTAAYNREQ | LWLANEGLIT | 
    800:
    KLQACCRGYL | VRQEFRSRMN | FLKKQIPAIT | CIQSQWRGYK | QKKAYQDRLA | 
    850:
    YLHSHKDEVV | KIQSLARMHQ | ARKRYRDRLQ | YFRDHINDII | KIQAFIRANK | 
    900:
    ARDDYKTLIN | AEDPPMIVVR | KFVHLLDQSD | QDFQEELDLM | KMREEVITLI | 
    950:
    RSNQQLENDL | NLMDIKIGLL | VKNKITLQDV | VSHSKKLTKK | NKEQLSDMMM | 
    1000:
    INKQKGGLKA | LSKEKREKLE | AYQHLFYLLQ | TNPTYLAKLI | FQMPQNKSTK | 
    1050:
    FMDSVIFTLY | NYASNQREEY | LLLRLFQTAL | QEEIKSKVDQ | IQEIVTGNPT | 
    1100:
    VIKMVVSFNR | GARGQNALRQ | ILAPVVKEIM | DDKSLNIKTD | PVDIYKSWVN | 
    1150:
    QMESQTGEAS | KLPYDVTPEQ | ALSHEEVKTR | LDNSIRNMRA | VTDKFLSAIV | 
    1200:
    SSVDKIPYGM | RFIAKVLKDS | LHEKFPDAGE | DELLKIIGNL | LYYRYMNPAI | 
    1250:
    VAPDAFDIID | LSAGGQLTTD | QRRNLGSIAK | MLQHAASNKM | FLGDNAHLSI | 
    1300:
    INEYLSQSYQ | KFRRFFQLAC | DVPELQDKFN | VDEYSDLVTL | TKPVIYISIG | 
    1350:
    EIINTHTLLL | DHQDAIAPEH | NDPIHELLDD | LGEVPTIESL | IGESCGNSND | 
    1400:
    PNKEALAKTE | VSLTLTNKFD | VPGDENAEMD | ARTILLNTKR | LIVDVIRFQP | 
    1450:
    GETLTEILET | PATNEQEAEH | QRAMQRRAIR | DAKTPDKMKK | SKPMKEDNNL | 
    1500:
    SLQEKKEKIQ | TGLKKLTELG | TVDPKNRYQE | LINDIAKDIR | NQRRYRQRRK | 
    1550:
    AELVKLQQTY | SALNSKATFY | GEQVDYYKSY | IKTCLDNLAS | KGKVSKKPRE | 
    1600:
    MKGKKSKKIS | LKYTAARLHE | KGVLLEIEDL | QANQFKNVIF | EIGPTEEVGD | 
    1650:
    FEVKAKFMGV | QMETFMLHYQ | DLLQLQYEGV | AVMKLFDRAK | VNVNLLIFLL | 
    1657:
    NKKFYGK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ras GTPase-activating-like protein IQGAP1
    Cat.:
    E10893h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Ras GTPase-activating-like protein IQGAP1
    Cat.:
    E10893m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ras GTPase-activating-like protein IQGAP1
    Cat.:
    U10893m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ras GTPase-activating-like protein IQGAP1
    Cat.:
    U10893h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Ras GTPase-activating-like protein IQGAP1
    Cat.:
    P10893Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Ras GTPase-activating-like protein IQGAP1
    Monoclonal Antibody for Mouse Ras GTPase-activating-like protein IQGAP1
    Monoclonal Antibody for Mouse Ras GTPase-activating-like protein IQGAP1
    Protein for Mouse Ras GTPase-activating-like protein IQGAP1
    Protein for Mouse Ras GTPase-activating-like protein IQGAP1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Sequence of Mus musculus Cdc42 effector protein IQGAP1."
      Bernards A.
      Submitted (2000-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Pre-B cell.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-172;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    5. 5.
      "Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42."
      Lin Q. , Yang W. , Baird D. , Feng Q. , Cerione R.A.
      J. Biol. Chem.281:35253-35262(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDC42
    6. 6.
      "The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migration."
      McLaughlin L.M. , Govoni G.R. , Gerke C. , Gopinath S. , Peng K. , Laidlaw G. , Chien Y.H. , Jeong H.W. , Li Z. , Brown M.D. , Sacks D.B. , Monack D.
      PLoS Pathog.5:E1000671-E1000671(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH S.TYPHIMURIUM SSEI
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