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Index > Protein center > Itga8(Gene name) > Mouse
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  • Itga8 (Gene name),
  • Integrin alpha-8 (Protein name ),  ITA8_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Itga8;
    Protein name:
    Integrin alpha-8;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1.
    Function:
    Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1062
    Sequence:
    50:
    MSAGTHCGPP | GNRAPPFARL | CCVSAALGML | WSPACLAFNL | DVDKLTVYSG | 
    100:
    PEGSYFGYSL | DFYIPDARTA | SVLVGAPKAN | TSQPDIVEGG | AVYYCPWPSE | 
    150:
    RSAQCKQIPF | DTTNNRKIRV | NGTKEPIEFK | SNQWFGATVR | AHKGKVVACA | 
    200:
    PLYHWRTLKP | NPAKDPVGTC | YVAIQNFSAY | AEHSPCRNSN | ADPEGQGYCQ | 
    250:
    AGFSLDFYKN | GDLIVGGPGS | FYWQGQVITV | SIADIIANYS | FKDILRKLAA | 
    300:
    EKQTDVAPAS | YDDSYLGYSV | AAGEFTGDSQ | QELVAGIPRG | AQNFGYVSII | 
    350:
    NSTDMTFIQN | FTGEQMASYF | GYTVVVSDVN | NDGMDDILVG | APLFMEREFE | 
    400:
    SNPREVGQVY | LYLQASALLF | QDPQVLTGTE | TFGRFGSSVA | HLGDLNQDGY | 
    450:
    NDIAIGVPFA | GKDQRGKVLI | YNGNPRGLHS | KPSQVLQGIW | GSQTIPSGFG | 
    500:
    FSLRGDADID | KNDYPDLLVG | AFGKGKVAVY | RARPVVTVDA | QLLLHPMIIN | 
    550:
    LENKTCQIPE | FPTPVACFSV | RVCASIAGQS | ISNTIALLAE | VQLDFLKQKG | 
    600:
    AIKRTLFLHN | HQSHFTFPFV | MKQQKSLHCQ | DFMVYLRDET | EFRDKLSPIN | 
    650:
    ISLNYSLDDS | TFKDSLEVKP | ILNHYRDNVV | TEQAHILVDC | GEDNLCVPDL | 
    700:
    KLSARPDKHQ | IIIGDENHLM | LIINARNEGE | GAYEAELFVI | IPEEADYVGI | 
    750:
    ERNNKGLRPL | SCEYKMENVT | RMVVCDLGNP | MVTGTNFSLG | LRFAVPRLEK | 
    800:
    TNMSINFDLQ | IRSSNKDNPD | SNFERVQINI | TAIAQVEIRG | VSHPPQIVLP | 
    850:
    IHNWEPEKKP | HKEEEVGPLV | EHIYELHNIG | PSTISDSILD | VGWPFSARDE | 
    900:
    FLLYIFHLQT | LGPLQCQTNP | EINPQDIKPA | ASPEDTPELS | AFLRNATIPH | 
    950:
    LVRKRDVPVV | QLHRQSPARI | LNCTNIDCLQ | ISCAVGRLGG | GESAVLKVRS | 
    1000:
    RLWAHTFLKR | KNDHYALASL | VSFEVKKMPY | KEQPAKLPAG | STAVKTSVIW | 
    1050:
    ATPNVSFSIP | LWVIILAILL | GLLVLAILTL | ALWKCGFFDR | ARPPQDEMTD | 
    1062:
    REQLTSDKTP | EA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Integrin alpha-8
    ELISA Kit for Mouse Integrin alpha-8
    ELISA Kit for Mouse Integrin alpha-8
    CLIA Kit for Mouse Integrin alpha-8
    CLIA Kit for Mouse Integrin alpha-8
    CLIA Kit for Mouse Integrin alpha-8
    Polyclonal Antibody for Mouse Integrin alpha-8
    Polyclonal Antibody for Mouse Integrin alpha-8
    Polyclonal Antibody for Mouse Integrin alpha-8
    Monoclonal Antibody for Mouse Integrin alpha-8
    Monoclonal Antibody for Mouse Integrin alpha-8
    Monoclonal Antibody for Mouse Integrin alpha-8
    Protein for Mouse Integrin alpha-8
    Protein for Mouse Integrin alpha-8
    Protein for Mouse Integrin alpha-8

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Testis.
      tissue: Wolffian duct.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis."
      Mueller U. , Wang D. , Denda S. , Meneses J.J. , Pedersen R.A. , Reichardt L.F.
      Cell88:603-613(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-1056 (ISOFORM 1);FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
      tissue: Fibroblast.
    4. 4.
      "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C."
      Denda S. , Mueller U. , Crossin K.L. , Erickson H.P. , Reichardt L.F.
      Biochemistry37:5464-5474(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis."
      Denda S. , Reichardt L.F. , Mueller U.
      Mol. Biol. Cell9:1425-1435(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Integrin subunit gene expression is regionally differentiated in adult brain."
      Pinkstaff J.K. , Detterich J. , Lynch G. , Gall C.
      J. Neurosci.19:1541-1556(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    7. 7.
      "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis."
      Hartner A. , Schoecklmann H. , Proels F. , Mueller U. , Sterzel R.B.
      Kidney Int.56:1468-1480(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    8. 8.
      "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1."
      Littlewood Evans A. , Mueller U.
      Nat. Genet.24:424-428(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION
    9. 9.
      "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney."
      Brandenberger R. , Schmidt A. , Linton J. , Wang D. , Backus C. , Denda S. , Mueller U. , Reichardt L.F.
      J. Cell Biol.154:447-458(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "The alpha8 integrin chain affords mechanical stability to the glomerular capillary tuft in hypertensive glomerular disease."
      Hartner A. , Cordasic N. , Klanke B. , Mueller U. , Sterzel R.B. , Hilgers K.F.
      Am. J. Pathol.160:861-867(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    11. 11.
      "Expression of the integrin subunit alpha8 in murine lung development."
      Wagner T.E. , Frevert C.W. , Herzog E.L. , Schnapp L.M.
      J. Histochem. Cytochem.51:1307-1315(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
    12. 12.
      "Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation."
      Bieritz B. , Spessotto P. , Colombatti A. , Jahn A. , Prols F. , Hartner A.
      Kidney Int.64:119-127(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression."
      Linton J.M. , Martin G.R. , Reichardt L.F.
      Development134:2501-2509(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
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