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Index > Protein center > PHF17(Gene name) > Human
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  • PHF17 (Gene name),
  • Protein Jade-1 (Protein name ),  JADE1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PHF17(JADE1;KIAA1807);
    Protein name:
    Protein Jade-1;
    Alternative:
    PHD finger protein 17;PHD finger protein 17;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16 and PHF17. Isoform 3 interacts with VHL and KAT5.
    Function:
    Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    842
    Sequence:
    50:
    MKRGRLPSSS | EDSDDNGSLS | TTWSQNSRSQ | HRRSSCSRHE | DRKPSEVFRT | 
    100:
    DLITAMKLHD | SYQLNPDEYY | VLADPWRQEW | EKGVQVPVSP | GTIPQPVARV | 
    150:
    VSEEKSLMFI | RPKKYIVSSG | SEPPELGYVD | IRTLADSVCR | YDLNDMDAAW | 
    200:
    LELTNEEFKE | MGMPELDEYT | MERVLEEFEQ | RCYDNMNHAI | ETEEGLGIEY | 
    250:
    DEDVVCDVCQ | SPDGEDGNEM | VFCDKCNICV | HQACYGILKV | PEGSWLCRTC | 
    300:
    ALGVQPKCLL | CPKKGGAMKP | TRSGTKWVHV | SCALWIPEVS | IGSPEKMEPI | 
    350:
    TKVSHIPSSR | WALVCSLCNE | KFGASIQCSV | KNCRTAFHVT | CAFDRGLEMK | 
    400:
    TILAENDEVK | FKSYCPKHSS | HRKPEESLGK | GAAQENGAPE | CSPRNPLEPF | 
    450:
    ASLEQNREEA | HRVSVRKQKL | QQLEDEFYTF | VNLLDVARAL | RLPEEVVDFL | 
    500:
    YQYWKLKRKV | NFNKPLITPK | KDEEDNLAKR | EQDVLFRRLQ | LFTHLRQDLE | 
    550:
    RVRNLTYMVT | RREKIKRSVC | KVQEQIFNLY | TKLLEQERVS | GVPSSCSSSS | 
    600:
    LENMLLFNSP | SVGPDAPKIE | DLKWHSAFFR | KQMGTSLVHS | LKKPHKRDPL | 
    650:
    QNSPGSEGKT | LLKQPDLCGR | REGMVVPESF | LGLEKTFAEA | RLISAQQKNG | 
    700:
    VVMPDHGKRR | DNRFHCDLIK | GDLKDKSFKQ | SHKPLRSTDV | SQRHLDNTRA | 
    750:
    ATSPGVGQSA | PGTRKEIVPK | CNGSLIKVNY | NQTAVKVPTT | PASPVKNWGG | 
    800:
    FRIPKKGERQ | QQGEAHDGAC | HQHSDYPYLG | LGRVPAKERA | KSKLKSDNEN | 
    842:
    DGYVPDVEMS | DSESEASEKK | CIHTSSTISR | RTDIIRRSIL | AS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    Pfam:
    KEGG:
    SMR:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein Jade-1
    ELISA Kit for Human Protein Jade-1
    ELISA Kit for Human Protein Jade-1
    CLIA Kit for Human Protein Jade-1
    CLIA Kit for Human Protein Jade-1
    CLIA Kit for Human Protein Jade-1
    Polyclonal Antibody for Human Protein Jade-1
    Polyclonal Antibody for Human Protein Jade-1
    Polyclonal Antibody for Human Protein Jade-1
    Monoclonal Antibody for Human Protein Jade-1
    Monoclonal Antibody for Human Protein Jade-1
    Monoclonal Antibody for Human Protein Jade-1
    Protein for Human Protein Jade-1
    Protein for Human Protein Jade-1
    Protein for Human Protein Jade-1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."
      Zhou M.I. , Wang H. , Ross J.J. , Kuzmin I. , Xu C. , Cohen H.T.
      J. Biol. Chem.277:39887-39898(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);INTERACTION WITH VHL;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Hippocampus.
    3. 3.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Cervix.
    6. 6.
      "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Nakayama M. , Nakajima D. , Kikuno R. , Ohara O.
      DNA Res.8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-842
      tissue: Brain.
    7. 7.
      "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
      Tzouanacou E. , Tweedie S. , Wilson V.
      Mol. Cell. Biol.23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION (ISOFORM 1)
    8. 8.
      "von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity."
      Panchenko M.V. , Zhou M.I. , Cohen H.T.
      J. Biol. Chem.279:56032-56041(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KAT5;SUBCELLULAR LOCATION;FUNCTION
    9. 9.
      "Jade-1, a candidate renal tumor suppressor that promotes apoptosis."
      Zhou M.I. , Foy R.L. , Chitalia V.C. , Zhao J. , Panchenko M.V. , Wang H. , Cohen H.T.
      Proc. Natl. Acad. Sci. U.S.A.102:11035-11040(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION
    10. 10.
      "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."
      Doyon Y. , Cayrou C. , Ullah M. , Landry A.-J. , Cote V. , Selleck W. , Lane W.S. , Tan S. , Yang X.-J. , Cote J.
      Mol. Cell21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HISTONE H4 ACETYLATION;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE HBO1 COMPLEX
    11. 11.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND THR-92;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92 AND SER-603;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    14. 14.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603 AND SER-743;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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