JAK3 ELISA Kit for Human(Homo sapiens) | EIAab.comJAK3 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > JAK3(Gene name) > Human

JAK3 (Gene name),

Tyrosine-protein kinase JAK3 (Protein name ), JAK3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

JAK3;

Protein name:

Tyrosine-protein kinase JAK3;

Alternative:

Leukocyte janus kinase(L-JAK);Janus kinase 3(JAK-3);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.

Function:

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

Subcellular Location:

Endomembrane system Peripheral membrane protein Cytoplasm

Protein Attributes:

Sequence length:

1124

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1124:

GSRGCETHAF | TAHPEGKHHS | LSFS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.515247

MIM:

600173

String:

P52333

SMR:

P52333

Pfam:

PF07714

KEGG:

hsa:3718

STRING:

9606.ENSP00000391676

Uniprot:

P52333

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ELISA Kit for Human Tyrosine-protein kinase JAK3

Cat.:

E0425r

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96T

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ELISA Kit for Human Tyrosine-protein kinase JAK3

Cat.:

E0425h

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96T

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ELISA Kit for Human Tyrosine-protein kinase JAK3

Cat.:

E0425m

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96T

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CLIA Kit for Human Tyrosine-protein kinase JAK3

Cat.:

U0425r

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Looking for manual.

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96T

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CLIA Kit for Human Tyrosine-protein kinase JAK3

Cat.:

U0425m

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MSDS:

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Packing:

96T

CLIA Kit for Human Tyrosine-protein kinase JAK3

Cat.:

U0425h

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Packing:

96T

Polyclonal Antibody for Human Tyrosine-protein kinase JAK3

Cat.:

P0425Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Tyrosine-protein kinase JAK3

Cat.:

P0425Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Tyrosine-protein kinase JAK3

Cat.:

P0425Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Tyrosine-protein kinase JAK3