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Index > Protein center > F11r(Gene name) > Mouse
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  • F11r (Gene name),
  • Junctional adhesion molecule A (Protein name ),  JAM1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    F11r(Jam1;Jcam;Jcam1);
    Protein name:
    Junctional adhesion molecule A(JAM-A);
    Alternative:
    Junctional adhesion molecule 1(JAM-1);
    CD:
    CD321;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein.
    Function:
    Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.
    Subcellular Location:
    Cell junction tight junction Cell membrane Single-pass type I membrane protein Localized at tight junctions of both epithelial and endothelial cells.
    Protein Attributes:
    Sequence length:
    300
    Sequence:
    50:
    MGTEGKAGRK | LLFLFTSMIL | GSLVQGKGSV | YTAQSDVQVP | ENESIKLTCT | 
    100:
    YSGFSSPRVE | WKFVQGSTTA | LVCYNSQITA | PYADRVTFSS | SGITFSSVTR | 
    150:
    KDNGEYTCMV | SEEGGQNYGE | VSIHLTVLVP | PSKPTISVPS | SVTIGNRAVL | 
    200:
    TCSEHDGSPP | SEYSWFKDGI | SMLTADAKKT | RAFMNSSFTI | DPKSGDLIFD | 
    250:
    PVTAFDSGEY | YCQAQNGYGT | AMRSEAAHMD | AVELNVGGIV | AAVLVTLILL | 
    300:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse JAM-A
    ELISA Kit for Mouse JAM-A
    ELISA Kit for Mouse JAM-A
    ELISA Kit for Mouse JAM-A
    CLIA Kit for Mouse JAM-A
    CLIA Kit for Mouse JAM-A
    CLIA Kit for Mouse JAM-A
    CLIA Kit for Mouse JAM-A
    Polyclonal Antibody for Mouse JAM-A
    Polyclonal Antibody for Mouse JAM-A
    Polyclonal Antibody for Mouse JAM-A
    Polyclonal Antibody for Mouse JAM-A
    Monoclonal Antibody for Mouse JAM-A
    Monoclonal Antibody for Mouse JAM-A
    Monoclonal Antibody for Mouse JAM-A
    Monoclonal Antibody for Mouse JAM-A
    Protein for Mouse JAM-A
    Protein for Mouse JAM-A
    Protein for Mouse JAM-A
    Protein for Mouse JAM-A

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration."
      Martin-Padura I. , Lostaglio S. , Schneemann M. , Williams L. , Romano M. , Fruscella P. , Panzeri C. , Stoppacciaro A. , Ruco L. , Villa A. , Simmons D. , Dejana E.
      J. Cell Biol.142:117-127(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Cecum.
    3. 3.
      "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L. , Muenstermann E. , Schatten R. , Henze S. , Bohn E. , Mollenhauer J. , Wiemann S. , Schick M. , Korn B.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    6. 6.
      "Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family?"
      Aurrand-Lions M.A. , Duncan L. , Du Pasquier L. , Imhof B.A.
      Curr. Top. Microbiol. Immunol.251:91-98(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    7. 7.
      "The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)."
      Ebnet K. , Suzuki A. , Horikoshi Y. , Hirose T. , Meyer zu Brickwedde M.-K. , Ohno S. , Vestweber D.
      EMBO J.20:3738-3748(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PARD3
    8. 8.
      "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response."
      Muller W.A.
      Trends Immunol.24:327-334(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;NOMENCLATURE
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    10. 10.
      "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
      Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-185
      tissue: Myoblast.
    11. 11.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-42 AND ASN-185
    12. 12.
      "X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif."
      Kostrewa D. , Brockhaus M. , D'Arcy A. , Dale G.E. , Nelboeck P. , Schmid G. , Mueller F. , Bazzoni G. , Dejana E. , Bartfai T. , Winkler F.K. , Hennig M.
      EMBO J.20:4391-4398(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 27-238
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