Protein name:
Junctional adhesion molecule A (JAM-A) ;
Alternative:
Junctional adhesion molecule 1 (JAM-1) ;
CD:
CD321 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein.
Function:
Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.
Subcellular Location:
Cell junction
tight junction
Cell membrane
Single-pass type I membrane protein
Localized at tight junctions of both epithelial and endothelial cells.
Protein Attributes:
50:
MGTEGKAGSK | LLFLFTSMIL | GSLVQGKGSV | YSPQTAVQVP | ENDSVKLPCI |
100:
YSGFSSPRVE | WKFVQGSTTA | LVCYNNQITV | PYADRVTFSS | SGITFSSVTR |
150:
KDNGEYTCMV | SEDGGQNYGE | VSIHLTVLVP | PSKPTVSIPS | SVTIGNRAVL |
200:
TCSEHDGSPP | SEYSWFKDGV | PMLTADAKKT | RAFINSSYTI | DPKSGDLVFD |
250:
PVSAFDSGEY | YCEAQNGYGT | AMRSEAVRME | AVELNVGGIV | AAVLVTLILL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
Polyclonal Antibody for Rat JAM-A
Polyclonal Antibody for Rat JAM-A
Polyclonal Antibody for Rat JAM-A
Polyclonal Antibody for Rat JAM-A
Monoclonal Antibody for Rat JAM-A
Monoclonal Antibody for Rat JAM-A
Monoclonal Antibody for Rat JAM-A
Monoclonal Antibody for Rat JAM-A
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Prostate .