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Index > Protein center > JAM3(Gene name) > Human
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  • JAM3 (Gene name),
  • Junctional adhesion molecule C (Protein name ),  JAM3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    JAM3(UNQ859/PRO1868);
    Protein name:
    Junctional adhesion molecule C(JAM-C);
    Alternative:
    Junctional adhesion molecule 3(JAM-3);JAM-2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with JAM2. Interacts with ITGAM.
    Function:
    Participates in cell-cell adhesion. It is a counterreceptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Cell junction desmosome Secreted extracellular space In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitement of JAM3 to cell-cell contacts.
    Protein Attributes:
    Sequence length:
    310
    Sequence:
    50:
    MALRRPPRLR | LCARLPDFFL | LLLFRGCLIG | AVNLKSSNRT | PVVQEFESVE | 
    100:
    LSCIITDSQT | SDPRIEWKKI | QDEQTTYVFF | DNKIQGDLAG | RAEILGKTSL | 
    150:
    KIWNVTRRDS | ALYRCEVVAR | NDRKEIDEIV | IELTVQVKPV | TPVCRVPKAV | 
    200:
    PVGKMATLHC | QESEGHPRPH | YSWYRNDVPL | PTDSRANPRF | RNSSFHLNSE | 
    250:
    TGTLVFTAVH | KDDSGQYYCI | ASNDAGSARC | EEQEMEVYDL | NIGGIIGGVL | 
    300:
    VVLAVLALIT | LGICCAYRRG | YFINNKQDGE | SYKNPGKPDG | VNYIRTDEEG | 
    310:
    DFRHKSSFVI | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    MIM:
    Pfam:
    String:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human JAM-C
    ELISA Kit for Human JAM-C
    ELISA Kit for Human JAM-C
    CLIA Kit for Human JAM-C
    CLIA Kit for Human JAM-C
    CLIA Kit for Human JAM-C
    Polyclonal Antibody for Human JAM-C
    Polyclonal Antibody for Human JAM-C
    Polyclonal Antibody for Human JAM-C
    Monoclonal Antibody for Human JAM-C
    Monoclonal Antibody for Human JAM-C
    Monoclonal Antibody for Human JAM-C
    Protein for Human JAM-C
    Protein for Human JAM-C
    Protein for Human JAM-C

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor."
      Arrate M.P. , Rodriguez J.M. , Tran T.M. , Brock T.A. , Cunningham S.A.
      J. Biol. Chem.276:45826-45832(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH JAM2;TISSUE SPECIFICITY
      tissue: Brain.
    2. 2.
      "Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members."
      Aurrand-Lions M.A. , Johnson-Leger C. , Wong C. , Du Pasquier L. , Imhof B.A.
      Blood98:3699-3707(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1."
      Santoso S. , Sachs U.J.H. , Kroll H. , Linder M. , Ruf A. , Preissner K.T. , Chavakis T.
      J. Exp. Med.196:679-691(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH ITGAM
    4. 4.
      "Narrowing the critical region within 11q24-qter for hypoplastic left heart and identification of a candidate gene, JAM3, expressed during cardiogenesis."
      Phillips H.M. , Renforth G.L. , Spalluto C. , Hearn T. , Curtis A.R.J. , Craven L. , Havarani B. , Clement-Jones M. , English C. , Stumper O. , Salmon T. , Hutchinson S. , Jackson M.S. , Wilson D.I.
      Genomics79:475-478(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Thalamus.
    6. 6.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Eye.
      tissue: Uterus.
    10. 10.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 32-46
    11. 11.
      "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response."
      Muller W.A.
      Trends Immunol.24:327-334(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;NOMENCLATURE
    12. 12.
      "JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration."
      Zen K. , Babbin B.A. , Liu Y. , Whelan J.B. , Nusrat A. , Parkos C.A.
      Mol. Biol. Cell15:3926-3937(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NEUTROPHIL TRANSEPITHELIAL MIGRATION;INTERACTION WITH ITGAM;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    13. 13.
      "Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth."
      Lamagna C. , Hodivala-Dilke K.M. , Imhof B.A. , Aurrand-Lions M.
      Cancer Res.65:5703-5710(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    14. 14.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-192 AND ASN-198
      tissue: Leukemic T-cell.
    15. 15.
      "A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts."
      Mochida G.H. , Ganesh V.S. , Felie J.M. , Gleason D. , Hill R.S. , Clapham K.R. , Rakiec D. , Tan W.H. , Akawi N. , Al-Saffar M. , Partlow J.N. , Tinschert S. , Barkovich A.J. , Ali B. , Al-Gazali L. , Walsh C.A.
      Am. J. Hum. Genet.87:882-889(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HDBSCC
    16. 16.
      "Junctional adhesion molecule-C is a soluble mediator of angiogenesis."
      Rabquer B.J. , Amin M.A. , Teegala N. , Shaheen M.K. , Tsou P.S. , Ruth J.H. , Lesch C.A. , Imhof B.A. , Koch A.E.
      J. Immunol.185:1777-1785(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANGIOGENESIS;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;PROTEOLYTIC CLEAVAGE BY ADAM10 AND ADAM17
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Delineation of the clinical, molecular and cellular aspects of novel JAM3 mutations underlying the autosomal recessive hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts."
      Akawi N.A. , Canpolat F.E. , White S.M. , Quilis-Esquerra J. , Morales Sanchez M. , Gamundi M.J. , Mochida G.H. , Walsh C.A. , Ali B.R. , Al-Gazali L.
      Hum. Mutat.34:498-505(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HDBSCC LYS-116 AND TYR-219;CHARACTERIZATION OF VARIANT HDBSCC TYR-219
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