Gene name:
JAM3 (UNQ859/PRO1868) ;
Protein name:
Junctional adhesion molecule C (JAM-C) ;
Alternative:
Junctional adhesion molecule 3 (JAM-3) ;JAM-2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with JAM2. Interacts with ITGAM.
Function:
Participates in cell-cell adhesion. It is a counterreceptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Cell junction
desmosome
Secreted
extracellular space
In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitement of JAM3 to cell-cell contacts.
Protein Attributes:
50:
MALRRPPRLR | LCARLPDFFL | LLLFRGCLIG | AVNLKSSNRT | PVVQEFESVE |
100:
LSCIITDSQT | SDPRIEWKKI | QDEQTTYVFF | DNKIQGDLAG | RAEILGKTSL |
150:
KIWNVTRRDS | ALYRCEVVAR | NDRKEIDEIV | IELTVQVKPV | TPVCRVPKAV |
200:
PVGKMATLHC | QESEGHPRPH | YSWYRNDVPL | PTDSRANPRF | RNSSFHLNSE |
250:
TGTLVFTAVH | KDDSGQYYCI | ASNDAGSARC | EEQEMEVYDL | NIGGIIGGVL |
300:
VVLAVLALIT | LGICCAYRRG | YFINNKQDGE | SYKNPGKPDG | VNYIRTDEEG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human JAM-C
ELISA Kit for Human JAM-C
ELISA Kit for Human JAM-C
Polyclonal Antibody for Human JAM-C
Polyclonal Antibody for Human JAM-C
Polyclonal Antibody for Human JAM-C
Monoclonal Antibody for Human JAM-C
Monoclonal Antibody for Human JAM-C
Monoclonal Antibody for Human JAM-C
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH JAM2;TISSUE SPECIFICITY
tissue :
Brain .
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH ITGAM
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Thalamus .
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Eye .
tissue :
Uterus .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 32-46
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW;NOMENCLATURE
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN NEUTROPHIL TRANSEPITHELIAL MIGRATION;INTERACTION WITH ITGAM;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;SUBCELLULAR LOCATION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-192 AND ASN-198
tissue :
Leukemic T-cell .
15.
"A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts."
Mochida G.H.
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Ganesh V.S.
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Felie J.M.
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Gleason D.
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Hill R.S.
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Clapham K.R.
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Ali B.
,
Al-Gazali L.
,
Walsh C.A.
Am. J. Hum. Genet.87:882-889(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN HDBSCC
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN ANGIOGENESIS;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;PROTEOLYTIC CLEAVAGE BY ADAM10 AND ADAM17
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
"Delineation of the clinical, molecular and cellular aspects of novel JAM3 mutations underlying the autosomal recessive hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts."
Akawi N.A.
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Canpolat F.E.
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White S.M.
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Al-Gazali L.
Hum. Mutat.34:498-505(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HDBSCC LYS-116 AND TYR-219;CHARACTERIZATION OF VARIANT HDBSCC TYR-219