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Index > Protein center > Jam3(Gene name) > Mouse
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  • Jam3 (Gene name),
  • Junctional adhesion molecule C (Protein name ),  JAM3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Jam3;
    Protein name:
    Junctional adhesion molecule C(JAM-C);
    Alternative:
    Junctional adhesion molecule 3(JAM-3);JAM-2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with JAM2 (By similarity). Interacts with ITGAM.
    Function:
    Participates in cell-cell adhesion. It is a counterreceptor for ITGAM mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (By similarity). The soluble form is a mediator of angiogenesis.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Cell junction desmosome Secreted extracellular space In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells. Treatment of endothelial cells with vascular endothelial growth factor stimulates recruitement of JAM3 to cell-cell contacts.
    Protein Attributes:
    Sequence length:
    310
    Sequence:
    50:
    MALSRRLRLR | LYARLPDFFL | LLLFRGCMIE | AVNLKSSNRN | PVVHEFESVE | 
    100:
    LSCIITDSQT | SDPRIEWKKI | QDGQTTYVYF | DNKIQGDLAG | RTDVFGKTSL | 
    150:
    RIWNVTRSDS | AIYRCEVVAL | NDRKEVDEIT | IELIVQVKPV | TPVCRIPAAV | 
    200:
    PVGKTATLQC | QESEGYPRPH | YSWYRNDVPL | PTDSRANPRF | QNSSFHVNSE | 
    250:
    TGTLVFNAVH | KDDSGQYYCI | ASNDAGAARC | EGQDMEVYDL | NIAGIIGGVL | 
    300:
    VVLIVLAVIT | MGICCAYRRG | CFISSKQDGE | SYKSPGKHDG | VNYIRTSEEG | 
    310:
    DFRHKSSFVI | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse JAM-C
    ELISA Kit for Mouse JAM-C
    ELISA Kit for Mouse JAM-C
    CLIA Kit for Mouse JAM-C
    CLIA Kit for Mouse JAM-C
    CLIA Kit for Mouse JAM-C
    Polyclonal Antibody for Mouse JAM-C
    Polyclonal Antibody for Mouse JAM-C
    Polyclonal Antibody for Mouse JAM-C
    Monoclonal Antibody for Mouse JAM-C
    Monoclonal Antibody for Mouse JAM-C
    Monoclonal Antibody for Mouse JAM-C
    Protein for Mouse JAM-C
    Protein for Mouse JAM-C
    Protein for Mouse JAM-C

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family?"
      Aurrand-Lions M.A. , Duncan L. , Du Pasquier L. , Imhof B.A.
      Curr. Top. Microbiol. Immunol.251:91-98(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "JAM-2, a novel immunoglobulin superfamily molecule, expressed by endothelial and lymphatic cells."
      Aurrand-Lions M.A. , Duncan L. , Ballestrem C. , Imhof B.A.
      J. Biol. Chem.276:2733-2741(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Small intestine.
      tissue: Wolffian duct.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Kidney.
    5. 5.
      Lubec G. , Kang S.U.
      Submitted (2007-04) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 84-91 AND 146-154;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      tissue: Brain.
    6. 6.
      "Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members."
      Aurrand-Lions M.A. , Johnson-Leger C. , Wong C. , Du Pasquier L. , Imhof B.A.
      Blood98:3699-3707(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    7. 7.
      "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response."
      Muller W.A.
      Trends Immunol.24:327-334(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;NOMENCLATURE
    8. 8.
      "Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth."
      Lamagna C. , Hodivala-Dilke K.M. , Imhof B.A. , Aurrand-Lions M.
      Cancer Res.65:5703-5710(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANGIOGENESIS
    9. 9.
      "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
      Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-192 AND ASN-198
      tissue: Myoblast.
    10. 10.
      "Junctional adhesion molecule-C is a soluble mediator of angiogenesis."
      Rabquer B.J. , Amin M.A. , Teegala N. , Shaheen M.K. , Tsou P.S. , Ruth J.H. , Lesch C.A. , Imhof B.A. , Koch A.E.
      J. Immunol.185:1777-1785(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANGIOGENESIS
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