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Index > Protein center > AMICA1(Gene name) > Human
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  • AMICA1 (Gene name),
  • Junctional adhesion molecule-like (Protein name ),  JAML1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AMICA1(UNQ722/PRO1387;JAML);
    Protein name:
    Junctional adhesion molecule-like;
    Alternative:
    Dendritic cell-specific protein CREA7-1;Adhesion molecule interacting with CXADR antigen 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CXADR.
    Function:
    May function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells.
    Subcellular Location:
    Cell junction Cell membrane Single-pass type I membrane protein Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN.
    Protein Attributes:
    Sequence length:
    394
    Sequence:
    50:
    MFCPLKLILL | PVLLDYSLGL | NDLNVSPPEL | TVHVGDSALM | GCVFQSTEDK | 
    100:
    CIFKIDWTLS | PGEHAKDEYV | LYYYSNLSVP | IGRFQNRVHL | MGDILCNDGS | 
    150:
    LLLQDVQEAD | QGTYICEIRL | KGESQVFKKA | VVLHVLPEEP | KELMVHVGGL | 
    200:
    IQMGCVFQST | EVKHVTKVEW | IFSGRRAKEE | IVFRYYHKLR | MSVEYSQSWG | 
    250:
    HFQNRVNLVG | DIFRNDGSIM | LQGVRESDGG | NYTCSIHLGN | LVFKKTIVLH | 
    300:
    VSPEEPRTLV | TPAALRPLVL | GGNQLVIIVG | IVCATILLLP | VLILIVKKTC | 
    350:
    GNKSSVNSTV | LVKNTKKTNP | EIKEKPCHFE | RCEGEKHIYS | PIIVREVIEE | 
    394:
    EEPSEKSEAT | YMTMHPVWPS | LRSDRNNSLE | KKSGGGMPKT | QQAF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    MIM:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Junctional adhesion molecule-like
    ELISA Kit for Human Junctional adhesion molecule-like
    CLIA Kit for Human Junctional adhesion molecule-like
    CLIA Kit for Human Junctional adhesion molecule-like
    Polyclonal Antibody for Human Junctional adhesion molecule-like
    Polyclonal Antibody for Human Junctional adhesion molecule-like
    Monoclonal Antibody for Human Junctional adhesion molecule-like
    Monoclonal Antibody for Human Junctional adhesion molecule-like
    Protein for Human Junctional adhesion molecule-like
    Protein for Human Junctional adhesion molecule-like

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells."
      Moog-Lutz C. , Cave-Riant F. , Guibal F.C. , Breau M.A. , Di Gioia Y. , Couraud P.O. , Cayre Y.E. , Bourdoulous S. , Lutz P.G.
      Blood102:3371-3378(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION IN LEUKOCYTE MIGRATION;INDUCTION;SUBCELLULAR LOCATION;DOMAIN;TISSUE SPECIFICITY;MUTAGENESIS OF LYS-54;VARIANT ALA-193
      tissue: Bone marrow.
    2. 2.
      "Dendritic cell specific protein Crea7-1."
      Ahn J.H. , Jung H.R. , Lee B.-H. , Jeon C.J. , Bae Y.-S.
      Submitted (2002-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ASN-94 AND ALA-193
      tissue: Dendritic cell.
    3. 3.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3);VARIANTS ASN-94 AND ALA-193
      tissue: Cerebellum.
      tissue: Spleen.
    5. 5.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
    8. 8.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-34
    9. 9.
      "Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils."
      Zen K. , Liu Y. , McCall I.C. , Wu T. , Lee W. , Babbin B.A. , Nusrat A. , Parkos C.A.
      Mol. Biol. Cell16:2694-2703(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LEUKOCYTE MIGRATION;INTERACTION WITH CXADR;SUBCELLULAR LOCATION;DOMAIN
    10. 10.
      "JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation."
      Luissint A.C. , Lutz P.G. , Calderwood D.A. , Couraud P.O. , Bourdoulous S.
      J. Cell Biol.183:1159-1173(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LEUKOCYTE MIGRATION;HOMODIMERIZATION;MUTAGENESIS OF LYS-54;INTERACTION WITH CXADR;TISSUE SPECIFICITY
    11. 11.
      "Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration."
      Guo Y.L. , Bai R. , Chen C.X. , Liu D.Q. , Liu Y. , Zhang C.Y. , Zen K.
      Arterioscler. Thromb. Vasc. Biol.29:75-83(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LEUKOCYTE MIGRATION;TISSUE SPECIFICITY
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