Protein name:
Protein Jumonji ;
Alternative:
Jumonji/ARID domain-containing protein 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Associates with a histone methyltransferase complex containing GLP1/EHMT1 and G9a/EHMT2. Interacts with SUZ12; the interaction is direct. Interacts with GATA4 (via the N-terminal region). Interacts with NKX2-5 (via the C-terminal region). Interacts with RB1. Interacts with ZNF496 (By similarity). Associates with the PRC2 complex, which includes EED, EZH1, EZH2, SUZ12, RBBP4 and AEBP2; JARID2 is probably not a core component of the PRC2 complex and associates to PRC2 via its interaction with SUZ12.
Function:
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
Subcellular Location:
Nucleus
Colocalizes with the PRC2 complex on chromatin.
Protein Attributes:
50:
MSKERPKRNI | IQKKYDDSDG | IPWSEERVVR | KVLYLSLKEF | KNSQKRQHAE |
100:
GIAGSLKTVN | GLLGNDQSKG | LGPASEQSEN | EKDDASQVSS | TSNDVSSSDF |
150:
EEGPSRKRPR | LQAQRKFAQS | QPNSPSTTPV | KIVEPLLPPP | ATQISDLSKR |
200:
KPKTEDFLTF | LCLRGSPALP | NSMVYFGSSQ | DEEEVEEEDD | ETEDVKTATN |
250:
NASSSCQSTP | RKGKTHKHVH | NGHVFNGSSR | STREKEPVQK | HKSKEATPAK |
300:
EKHSDHRADS | RREQASANHP | AAAPSTGSSA | KGLAATHHHP | PLHRSAQDLR |
350:
KQVSKVNGVT | RMSSLGAGVT | SAKKMREVRP | SPSKTVKYTA | TVTKGAVTYT |
400:
KAKRELVKDT | KPNHHKPSSA | VNHTISGKTE | SSNAKTRKQV | LSLGGASKST |
450:
GPAVNGLKVS | GRLNPKSCTK | EVGGRQLREG | LQLREGLRNS | KRRLEEAHQA |
500:
EKPQSPPKKM | KGAAGPAEGP | GKKAPAERGL | LNGHVKKEVP | ERSLERNRPK |
550:
RATAGKSTPG | RQAHGKADSA | SCENRSTSQP | ESVHKPQDSG | KAEKGGGKAG |
600:
WAAMDEIPVL | RPSAKEFHDP | LIYIESVRAQ | VEKFGMCRVI | PPPDWRPECK |
650:
LNDEMRFVTQ | IQHIHKLGRR | WGPNVQRLAC | IKKHLKSQGI | TMDELPLIGG |
700:
CELDLACFFR | LINEMGGMQQ | VTDLKKWNKL | ADMLRIPRTA | QDRLAKLQEA |
750:
YCQYLLSYDS | LSPEEHRRLE | KEVLMEKEIL | EKRKGPLEGH | TENDHHKFHP |
800:
LPRFEPKNGL | IHGVAPRNGF | RSKLKEVGQA | QLKTGRRRLF | AQEKEVVKEE |
850:
EEDKGVLNDF | HKCIYKGRSV | SLTTFYRTAR | NIMSMCFSKE | PAPAEIEQEY |
900:
WRLVEEKDCH | VAVHCGKVDT | NTHGSGFPVG | KSEPFSRHGW | NLTVLPNNTG |
950:
SILRHLGAVP | GVTIPWLNIG | MVFSTSCWSR | DQNHLPYIDY | LHTGADCIWY |
1000:
CIPAEEENKL | EDVVHTLLQA | NGTPGLQMLE | SNVMISPEVL | CKEGIKVHRT |
1050:
VQQSGQFVVC | FPGSFVSKVC | CGYSVSETVH | FATTQWTSMG | FETAKEMKRR |
1100:
HIAKPFSMEK | LLYQIAQAEA | KKENGPTLST | ISALLDELRD | TELRQRRQLF |
1150:
EAGLHSSARY | GSHDGSSTVA | DGKKKPRKWL | QLETSERRCQ | ICQHLCYLSM |
1200:
VVQENENVVF | CLECALRHVE | KQKSCRGLKL | MYRYDEEQII | SLVNQICGKV |
1246:
SGKNGSIENC | LSKPTPKRGP | RKRATVDVPP | SRLSASSSSK | SASSSS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
ELISA Kit for Human Protein Jumonji
ELISA Kit for Human Protein Jumonji
ELISA Kit for Human Protein Jumonji
CLIA Kit for Human Protein Jumonji
CLIA Kit for Human Protein Jumonji
CLIA Kit for Human Protein Jumonji
Polyclonal Antibody for Human Protein Jumonji
Polyclonal Antibody for Human Protein Jumonji
Polyclonal Antibody for Human Protein Jumonji
Monoclonal Antibody for Human Protein Jumonji
Monoclonal Antibody for Human Protein Jumonji
Monoclonal Antibody for Human Protein Jumonji
Protein for Human Protein Jumonji
Protein for Human Protein Jumonji
Protein for Human Protein Jumonji
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
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Thymus .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Mammary gland .
tissue :
Testis .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-378;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;ASSOCIATION WITH THE PRC2 COMPLEX
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78 AND SER-455;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]