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Index > Protein center > JARID2(Gene name) > Human
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  • JARID2 (Gene name),
  • Protein Jumonji (Protein name ),  JARD2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    JARID2(JMJ);
    Protein name:
    Protein Jumonji;
    Alternative:
    Jumonji/ARID domain-containing protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Associates with a histone methyltransferase complex containing GLP1/EHMT1 and G9a/EHMT2. Interacts with SUZ12; the interaction is direct. Interacts with GATA4 (via the N-terminal region). Interacts with NKX2-5 (via the C-terminal region). Interacts with RB1. Interacts with ZNF496 (By similarity). Associates with the PRC2 complex, which includes EED, EZH1, EZH2, SUZ12, RBBP4 and AEBP2; JARID2 is probably not a core component of the PRC2 complex and associates to PRC2 via its interaction with SUZ12.
    Function:
    Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
    Subcellular Location:
    Nucleus Colocalizes with the PRC2 complex on chromatin.
    Protein Attributes:
    Sequence length:
    1246
    Sequence:
    50:
    MSKERPKRNI | IQKKYDDSDG | IPWSEERVVR | KVLYLSLKEF | KNSQKRQHAE | 
    100:
    GIAGSLKTVN | GLLGNDQSKG | LGPASEQSEN | EKDDASQVSS | TSNDVSSSDF | 
    150:
    EEGPSRKRPR | LQAQRKFAQS | QPNSPSTTPV | KIVEPLLPPP | ATQISDLSKR | 
    200:
    KPKTEDFLTF | LCLRGSPALP | NSMVYFGSSQ | DEEEVEEEDD | ETEDVKTATN | 
    250:
    NASSSCQSTP | RKGKTHKHVH | NGHVFNGSSR | STREKEPVQK | HKSKEATPAK | 
    300:
    EKHSDHRADS | RREQASANHP | AAAPSTGSSA | KGLAATHHHP | PLHRSAQDLR | 
    350:
    KQVSKVNGVT | RMSSLGAGVT | SAKKMREVRP | SPSKTVKYTA | TVTKGAVTYT | 
    400:
    KAKRELVKDT | KPNHHKPSSA | VNHTISGKTE | SSNAKTRKQV | LSLGGASKST | 
    450:
    GPAVNGLKVS | GRLNPKSCTK | EVGGRQLREG | LQLREGLRNS | KRRLEEAHQA | 
    500:
    EKPQSPPKKM | KGAAGPAEGP | GKKAPAERGL | LNGHVKKEVP | ERSLERNRPK | 
    550:
    RATAGKSTPG | RQAHGKADSA | SCENRSTSQP | ESVHKPQDSG | KAEKGGGKAG | 
    600:
    WAAMDEIPVL | RPSAKEFHDP | LIYIESVRAQ | VEKFGMCRVI | PPPDWRPECK | 
    650:
    LNDEMRFVTQ | IQHIHKLGRR | WGPNVQRLAC | IKKHLKSQGI | TMDELPLIGG | 
    700:
    CELDLACFFR | LINEMGGMQQ | VTDLKKWNKL | ADMLRIPRTA | QDRLAKLQEA | 
    750:
    YCQYLLSYDS | LSPEEHRRLE | KEVLMEKEIL | EKRKGPLEGH | TENDHHKFHP | 
    800:
    LPRFEPKNGL | IHGVAPRNGF | RSKLKEVGQA | QLKTGRRRLF | AQEKEVVKEE | 
    850:
    EEDKGVLNDF | HKCIYKGRSV | SLTTFYRTAR | NIMSMCFSKE | PAPAEIEQEY | 
    900:
    WRLVEEKDCH | VAVHCGKVDT | NTHGSGFPVG | KSEPFSRHGW | NLTVLPNNTG | 
    950:
    SILRHLGAVP | GVTIPWLNIG | MVFSTSCWSR | DQNHLPYIDY | LHTGADCIWY | 
    1000:
    CIPAEEENKL | EDVVHTLLQA | NGTPGLQMLE | SNVMISPEVL | CKEGIKVHRT | 
    1050:
    VQQSGQFVVC | FPGSFVSKVC | CGYSVSETVH | FATTQWTSMG | FETAKEMKRR | 
    1100:
    HIAKPFSMEK | LLYQIAQAEA | KKENGPTLST | ISALLDELRD | TELRQRRQLF | 
    1150:
    EAGLHSSARY | GSHDGSSTVA | DGKKKPRKWL | QLETSERRCQ | ICQHLCYLSM | 
    1200:
    VVQENENVVF | CLECALRHVE | KQKSCRGLKL | MYRYDEEQII | SLVNQICGKV | 
    1246:
    SGKNGSIENC | LSKPTPKRGP | RKRATVDVPP | SRLSASSSSK | SASSSS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    MIM:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein Jumonji
    ELISA Kit for Human Protein Jumonji
    ELISA Kit for Human Protein Jumonji
    CLIA Kit for Human Protein Jumonji
    CLIA Kit for Human Protein Jumonji
    CLIA Kit for Human Protein Jumonji
    Polyclonal Antibody for Human Protein Jumonji
    Polyclonal Antibody for Human Protein Jumonji
    Polyclonal Antibody for Human Protein Jumonji
    Monoclonal Antibody for Human Protein Jumonji
    Monoclonal Antibody for Human Protein Jumonji
    Monoclonal Antibody for Human Protein Jumonji
    Protein for Human Protein Jumonji
    Protein for Human Protein Jumonji
    Protein for Human Protein Jumonji

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
      tissue: Thymus.
      tissue: Trachea.
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Mammary gland.
      tissue: Testis.
    6. 6.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-378;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    7. 7.
      "JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells."
      Pasini D. , Cloos P.A. , Walfridsson J. , Olsson L. , Bukowski J.P. , Johansen J.V. , Bak M. , Tommerup N. , Rappsilber J. , Helin K.
      Nature464:306-310(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;ASSOCIATION WITH THE PRC2 COMPLEX
    8. 8.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78 AND SER-455;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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