Jarid2 ELISA Kit for Mouse(Mus musculus) | EIAab.comJarid2 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Jarid2 (Gene name),

Protein Jumonji (Protein name ), JARD2_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

Jarid2(Jmj);

Protein name:

Protein Jumonji;

Alternative:

Jumonji/ARID domain-containing protein 2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Associates with the PRC2 complex, which includes EED, EZH1, EZH2, SUZ12, RBBP4 and AEBP2; JARID2 is probably not a core component of the PRC2 complex and associates to PRC2 via its interaction with SUZ12. Associates with a histone methyltransferase complex containing GLP1/EHMT1 and G9a/EHMT2. Interacts with SUZ12; the interaction is direct. Interacts with GATA4 (via the N-terminal region). Interacts with NKX2-5 (via the C-terminal region). Interacts with RB1. Interacts with ZNF496.

Function:

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

Subcellular Location:

Nucleus Colocalizes with the PRC2 complex on chromatin.

Protein Attributes:

Sequence length:

1234

Sequence:

50:

MSKERPKRNI | IQKKYDDSDG | IPWSEERVVR | KVLYLSLKEF | KNAQKRQHGE |

100:

GLAGSLKAVN | GLLGNAQAKA | LGPASEQSEN | EKDDASQVSS | TSNDVSSSDF |

150:

EEGPSRKRPR | LQAQRKFAQS | QPNSPSTTPV | KIVEPLLPPP | ATQISDLSKR |

200:

KPKTEDFLTF | LCLRGSPALP | NSMVYFGSSQ | DEEDVEEEDD | ETEDVKATTN |

250:

NASSSCQSTP | RKGKTHKHVH | NGHVFNGSSR | SAREKEPAHK | HRSKEATPGK |

300:

EKHSEPRADS | RREQASGAQP | TAASAAASSA | KGLAANHQPP | PSHRSAQDLR |

350:

KQVSKVNGVT | RMSSLGAGTN | SAKKIREVRP | SPSKTVKYTA | TVTKGTVTYT |

400:

KAKRELVKET | KPNHHKPSSA | VNHTISGKTE | SSNAKTRKQV | LSLGGASKST |

450:

GPAASGLKAS | SRLNPKSCTK | EVGGRQLREG | LRNSKRRLEE | AQQVDKPQSP |

500:

PKKMKGVAGN | AEAPGKKASA | ASGEKSLLNG | HVKKEVPERS | LERNRPKRAA |

550:

AGKNMLGKQA | HGKTEGTPCE | NRSTSQPESS | HKPHDPQGKP | EKGSGKSGWA |

600:

AMDEIPVLRP | SAKEFHDPLI | YIESVRAQVE | KYGMCRVIPP | PDWRPECKLN |

650:

DEMRFVTQIQ | HIHKLGRRWG | PNVQRLACIK | KHLRSQGITM | DELPLIGGCE |

700:

LDLACFFRLI | NEMGGMQQVT | DLKKWNKLAD | MLRIPKTAQD | RLAKLQEAYC |

750:

QYLLSYDSLS | PEEHRRLEKE | VLMEKEILEK | RKGPLEGHTE | SDHHKFHSLP |

800:

RFEPKNGLVH | GVTPRNGFRS | KLKEVGRAPL | KTGRRRLFAQ | EKEVVKEEEE |

850:

DKGVLNDFHK | CIYKGRSVSL | TTFYRTARNI | MNMCFSKEPA | PAEIEQEYWR |

900:

LVEEKDCHVA | VHCGKVDTNT | HGSGFPVGKS | EPFSRHGWNL | TVLPNNTGSI |

950:

LRHLGAVPGV | TIPWLNIGMV | FSTSCWSRDQ | NHLPYIDYLH | TGADCIWYCI |

1000:

PAEEENKLED | VVHTLLQGNG | TPGLQMLESN | VMISPEVLCK | KGIKVHRTVQ |

1050:

QSGQFVVCFP | GSFVSKVCCG | YNVSETVHFA | TTQWTSMGFE | TAKEMKRRHI |

1100:

AKPFSMEKLL | YQIAQAEAKK | ENGPTLSTIS | ALLDELRDTE | LRQRRLLFEA |

1150:

GLHSSARYGS | HDGNSTVADG | KKKPRKWLQL | ETSERRCQIC | QHLCYLSMVV |

1200:

QENENVVFCL | ECALRHVEKQ | KSCRGLKLMY | RYDEEQIISL | VNQICGKVSG |

1234:

KHGGIENCLN | KPTPKRGPRK | RATVDVPPSR | LPSS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

UniGene:

Pfam:

KEGG:

SMR:

Uniprot:

FOR

ELISA Kit for Mouse Protein Jumonji

ELISA Kit for Mouse Protein Jumonji

ELISA Kit for Mouse Protein Jumonji

CLIA Kit for Mouse Protein Jumonji

CLIA Kit for Mouse Protein Jumonji

CLIA Kit for Mouse Protein Jumonji

Polyclonal Antibody for Mouse Protein Jumonji

Polyclonal Antibody for Mouse Protein Jumonji

Polyclonal Antibody for Mouse Protein Jumonji

Monoclonal Antibody for Mouse Protein Jumonji

Monoclonal Antibody for Mouse Protein Jumonji

Monoclonal Antibody for Mouse Protein Jumonji

Protein for Mouse Protein Jumonji

Protein for Mouse Protein Jumonji

Protein for Mouse Protein Jumonji

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation."
Takeuchi T. , Yamazaki Y. , Katoh-Fukui Y. , Tsuchiya R. , Kondo S. , Motoyama J. , Higashinakagawa T.
Genes Dev.9:1211-1222(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DISRUPTION PHENOTYPE
strain: 129/Ola.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1068 (ISOFORM 2)
strain: C57BL/6J.
tissue: Embryo.
tissue: Placenta.
tissue: Spinal cord.
3.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
strain: Czech II.
tissue: Brain.
tissue: Mammary gland.
5.

"Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice."
Motoyama J. , Kitajima K. , Kojima M. , Kondo S. , Takeuchi T.
Mech. Dev.66:27-37(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
6.

"jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background."
Takeuchi T. , Kojima M. , Nakajima K. , Kondo S.
Mech. Dev.86:29-38(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
7.

"Jumonji is a nuclear protein that participates in the negative regulation of cell growth."
Toyoda M. , Kojima M. , Takeuchi T.
Biochem. Biophys. Res. Commun.274:332-336(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
8.

"Jumonji, a nuclear protein that is necessary for normal heart development."
Lee Y. , Song A.J. , Baker R. , Micales B. , Conway S.J. , Lyons G.E.
Circ. Res.86:932-938(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
9.

"jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression."
Toyoda M. , Shirato H. , Nakajima K. , Kojima M. , Takahashi M. , Kubota M. , Suzuki-Migishima R. , Motegi Y. , Yokoyama M. , Takeuchi T.
Dev. Cell5:85-97(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor."
Kim T.-G. , Kraus J.C. , Chen J. , Lee Y.
J. Biol. Chem.278:42247-42255(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;NUCLEAR LOCALIZATION SIGNAL;MUTAGENESIS OF 106-ARG-LYS-107
11.

"Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors."
Kim T.-G. , Chen J. , Sadoshima J. , Lee Y.
Mol. Cell. Biol.24:10151-10160(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GATA4 AND NKX2-5
12.

"Characterization of zinc finger protein 496 that interacts with Jumonji/JARID2."
Mysliwiec M.R. , Kim T.G. , Lee Y.
FEBS Lett.581:2633-2640(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF496
13.

"Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein."
Jung J. , Kim T.G. , Lyons G.E. , Kim H.R. , Lee Y.
J. Biol. Chem.280:30916-30923(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RB1
14.

"Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells."
Shen X. , Kim W. , Fujiwara Y. , Simon M.D. , Liu Y. , Mysliwiec M.R. , Yuan G.C. , Lee Y. , Orkin S.H.
Cell139:1303-1314(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;LACK OF HISTONE DEMETHYLASE ACTIVITY;SUBCELLULAR LOCATION;ASSOCIATION WITH THE PRC2 COMPLEX
15.

"Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells."
Peng J.C. , Valouev A. , Swigut T. , Zhang J. , Zhao Y. , Sidow A. , Wysocka J.
Cell139:1290-1302(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;ASSOCIATION WITH THE PRC2 COMPLEX;DOMAIN GSGFP MOTIF;INTERACTION WITH SUZ12
16.

"A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9."
Shirato H. , Ogawa S. , Nakajima K. , Inagawa M. , Kojima M. , Tachibana M. , Shinkai Y. , Takeuchi T.
J. Biol. Chem.284:733-739(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells."
Pasini D. , Cloos P.A. , Walfridsson J. , Olsson L. , Bukowski J.P. , Johansen J.V. , Bak M. , Tommerup N. , Rappsilber J. , Helin K.
Nature464:306-310(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;DOMAIN ARID
18.

"Solution structure of the AT-rich interaction domain of Jumonji/JARID2."
Kusunoki H. , Takeuchi T. , Kohno T.
Proteins76:1023-1028(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 615-730

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