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Index > Protein center > JDP2(Gene name) > Human
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  • JDP2 (Gene name),
  • Jun dimerization protein 2 (Protein name ),  JDP2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    JDP2;
    Protein name:
    Jun dimerization protein 2;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer.
    Function:
    Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    163
    Sequence:
    50:
    MMPGQIPDPS | VTTGSLPGLG | PLTGLPSSAL | TVEELKYADI | RNLGAMIAPL | 
    100:
    HFLEVKLGKR | PQPVKSELDE | EEERRKRRRE | KNKVAAARCR | NKKKERTEFL | 
    150:
    QRESERLELM | NAELKTQIEE | LKQERQQLIL | MLNRHRPTCI | VRTDSVKTPE | 
    163:
    SEGNPLLEQL | EKK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Jun dimerization protein 2
    ELISA Kit for Human Jun dimerization protein 2
    ELISA Kit for Human Jun dimerization protein 2
    CLIA Kit for Human Jun dimerization protein 2
    CLIA Kit for Human Jun dimerization protein 2
    CLIA Kit for Human Jun dimerization protein 2
    Polyclonal Antibody for Human Jun dimerization protein 2
    Polyclonal Antibody for Human Jun dimerization protein 2
    Polyclonal Antibody for Human Jun dimerization protein 2
    Monoclonal Antibody for Human Jun dimerization protein 2
    Monoclonal Antibody for Human Jun dimerization protein 2
    Monoclonal Antibody for Human Jun dimerization protein 2
    Protein for Human Jun dimerization protein 2
    Protein for Human Jun dimerization protein 2
    Protein for Human Jun dimerization protein 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL."
      Kawaida R. , Ohtsuka T. , Okutsu J. , Takahashi T. , Kadono Y. , Oda H. , Hikita A. , Nakamura K. , Tanaka S. , Furukawa H.
      J. Exp. Med.197:1029-1035(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
    2. 2.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
    5. 5.
      "Transcriptional regulation of the c-jun gene by AP-1 repressor protein JDP2 during the differentiation of F9 cells."
      Jin C. , Li H. , Ugai H. , Murata T. , Yokoyama K.K.
      Nucleic Acids Res. Suppl.2:97-98(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2."
      Jin C. , Kato K. , Chimura T. , Yamasaki T. , Nakade K. , Murata T. , Li H. , Pan J. , Zhao M. , Sun K. , Chiu R. , Ito T. , Nagata K. , Horikoshi M. , Yokoyama K.K.
      Nat. Struct. Mol. Biol.13:331-338(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis."
      Lerdrup M. , Holmberg C. , Dietrich N. , Shaulian E. , Herdegen T. , Jaeaettelae M. , Kallunki T.
      Biochim. Biophys. Acta1745:29-37(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1."
      Murata T. , Shinozuka Y. , Obata Y. , Yokoyama K.K.
      Anal. Biochem.376:115-121(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-148 BY MAPK8;IDENTIFICATION BY MASS SPECTROMETRY
    9. 9.
      "IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription."
      Kimura M.
      FEBS Lett.582:2833-2837(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH IRF2BP1
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