Gene name:
JMJD1C(JHDM2C;KIAA1380;TRIP8);
Protein name:
Probable JmjC domain-containing histone demethylation protein 2C;
Alternative:
Thyroid receptor-interacting protein 8(TR-interacting protein 8;TRIP-8);Jumonji domain-containing protein 1C;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.
Function:
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MAVETRAELV | GKRFLCVAVG | DEARSERWES | GRGWRSWRAG | VIRAVSHRDS |
100:
RNPDLAVYVE | FDDLEWDKRE | WVKVYEDFST | FLVEYHLIWA | KRNDPSQTQG |
150:
SKSKQIQWPA | LTFKPLVERN | IPSSVTAVEF | LVDKQLDFLT | EDSAFQPYQD |
200:
DIDSLNPVLR | DNPQLHEEVK | VWVKEQKVQE | IFMQGPYSLN | GYRVRVYRQD |
250:
SATQWFTGII | THHDLFTRTM | IVMNDQVLEP | QNVDPSMVQM | TFLDDVVHSL |
300:
LKGENIGITS | RRRSRANQNV | NAVHSHYTRA | QANSPRPAMN | SQAAVPKQNT |
350:
HQQQQQRSIR | PNKRKGSDSS | IPDEEKMKEE | KYDYISRGEN | PKGKNKHLMN |
400:
KRRKPEEDEK | KLNMKRLRTD | NVSDFSESSD | SENSNKRIID | NSSEQKPENE |
450:
LKNKNTSKIN | GEEGKPHNNE | KAGEETLKNS | QPPWDQIQED | KKHEEAEKRK |
500:
SVDTQLQEDM | IIHSSEQSTV | SDHNSNDLLP | QECNMDKTHT | MELLPKEKFV |
550:
SRPPTPKCVI | DITNDTNLEK | VAQENSSTFG | LQTLQKMDPN | VSDSKHSIAN |
600:
AKFLETAKKD | SDQSWVSDVV | KVDLTQSSVT | NASSGNDHLN | MEKEKYVSYI |
650:
SPLSAVSVME | DKLHKRSPPP | ETIKSKLNTS | VDTHKIKSSP | SPEVVKPKIT |
700:
HSPDSVKSKA | TYVNSQATGE | RRLANKIEHE | LSRCSFHPIP | TRSSTLETTK |
750:
SPLIIDKNEH | FTVYRDPALI | GSETGANHIS | PFLSQHPFPL | HSSSHRTCLN |
800:
PGTHHPALTP | APHLLAGSSS | QTPLPTINTH | PLTSGPHHAV | HHPHLLPTVL |
850:
PGVPTASLLG | GHPRLESAHA | SSLSHLALAH | QQQQQLLQHQ | SPHLLGQAHP |
900:
SASYNQLGLY | PIIWQYPNGT | HAYSGLGLPS | SKWVHPENAV | NAEASLRRNS |
950:
PSPWLHQPTP | VTSADGIGLL | SHIPVRPSSA | EPHRPLKITA | HSSPPLTKTL |
1000:
VDHHKEELER | KAFMEPLRSV | ASTSAKNDLD | LNRSQTGKDC | HLHRHFVDPV |
1050:
LNQLQRPPQE | TGERLNKYKE | EHRRILQESI | DVAPFTTKIK | GLEGERENYS |
1100:
RVASSSSSPK | SHIIKQDMDV | ERSVSDLYKM | KHSVPQSLPQ | SNYFTTLSNS |
1150:
VVNEPPRSYP | SKEVSNIYGD | KQSNALAAAA | ANPQTLTSFI | TSLSKPPPLI |
1200:
KHQPESEGLV | GKIPEHLPHQ | IASHSVTTFR | NDCRSPTHLT | VSSTNTLRSM |
1250:
PALHRAPVFH | PPIHHSLERK | EGSYSSLSPP | TLTPVMPVNA | GGKVQESQKP |
1300:
PTLIPEPKDS | QANFKSSSEQ | SLTEMWRPNN | NLSKEKTEWH | VEKSSGKLQA |
1350:
AMASVIVRPS | SSTKTDSMPA | MQLASKDRVS | ERSSAGAHKT | DCLKLAEAGE |
1400:
TGRIILPNVN | SDSVHTKSEK | NFQAVSQGSV | PSSVMSAVNT | MCNTKTDVIT |
1450:
SAADTTSVSS | WGGSEVISSL | SNTILASTSS | ECVSSKSVSQ | PVAQKQECKV |
1500:
STTAPVTLAS | SKTGSVVQPS | SGFSGTTDFI | HLKKHKAALA | AAQYKSSNAS |
1550:
ETEPNAIKNQ | TLSASLPLDS | TVICSTINKA | NSVGNGQASQ | TSQPNYHTKL |
1600:
KKAWLTRHSE | EDKNTNKMEN | SGNSVSEIIK | PCSVNLIAST | SSDIQNSVDS |
1650:
KIIVDKYVKD | DKVNRRKAKR | TYESGSESGD | SDESESKSEQ | RTKRQPKPTY |
1700:
KKKQNDLQKR | KGEIEEDLKP | NGVLSRSAKE | RSKLKLQSNS | NTGIPRSVLK |
1750:
DWRKVKKLKQ | TGESFLQDDS | CCEIGPNLQK | CRECRLIRSK | KGEEPAHSPV |
1800:
FCRFYYFRRL | SFSKNGVVRI | DGFSSPDQYD | DEAMSLWTHE | NFEDDELDIE |
1850:
TSKYILDIIG | DKFCQLVTSE | KTALSWVKKD | AKIAWKRAVR | GVREMCDACE |
1900:
ATLFNIHWVC | QKCGFVVCLD | CYKAKERKSS | RDKELYAWMK | CVKGQPHDHK |
1950:
HLMPTQIIPG | SVLTDLLDAM | HTLREKYGIK | SHCHCTNKQN | LQVGNFPTMN |
2000:
GVSQVLQNVL | NHSNKISLCM | PESQQQNTPP | KSEKNGGSSP | ESDVGTDNKL |
2050:
TPPESQSPLH | WLADLAEQKA | REEKKENKEL | TLENQIKEER | EQDNSESPNG |
2100:
RTSPLVSQNN | EQGSTLRDLL | TTTAGKLRVG | STDAGIAFAP | VYSMGAPSSK |
2150:
SGRTMPNILD | DIIASVVENK | IPPSKTSKIN | VKPELKEEPE | ESIISAVDEN |
2200:
NKLYSDIPHS | WICEKHILWL | KDYKNSSNWK | LFKECWKQGQ | PAVVSGVHKK |
2250:
MNISLWKAES | ISLDFGDHQA | DLLNCKDSII | SNANVKEFWD | GFEEVSKRQK |
2300:
NKSGETVVLK | LKDWPSGEDF | KTMMPARYED | LLKSLPLPEY | CNPEGKFNLA |
2350:
SHLPGFFVRP | DLGPRLCSAY | GVVAAKDHDI | GTTNLHIEVS | DVVNILVYVG |
2400:
IAKGNGILSK | AGILKKFEEE | DLDDILRKRL | KDSSEIPGAL | WHIYAGKDVD |
2450:
KIREFLQKIS | KEQGLEVLPE | HDPIRDQSWY | VNKKLRQRLL | EEYGVRTCTL |
2500:
IQFLGDAIVL | PAGALHQVQN | FHSCIQVTED | FVSPEHLVES | FHLTQELRLL |
2540:
KEEINYDDKL | QVKNILYHAV | KEMVRALKIH | EDEVEDMEEN |
Vaild Sequence:
Related Databases
Uniprot: