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Index > Protein center > JMJD1C(Gene name) > Human
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  • JMJD1C (Gene name),
  • Probable JmjC domain-containing histone demethylation protein 2C (Protein name ),  JHD2C_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    JMJD1C(JHDM2C;KIAA1380;TRIP8);
    Protein name:
    Probable JmjC domain-containing histone demethylation protein 2C;
    Alternative:
    Thyroid receptor-interacting protein 8(TR-interacting protein 8;TRIP-8);Jumonji domain-containing protein 1C;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.
    Function:
    Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    2540
    Sequence:
    50:
    MAVETRAELV | GKRFLCVAVG | DEARSERWES | GRGWRSWRAG | VIRAVSHRDS | 
    100:
    RNPDLAVYVE | FDDLEWDKRE | WVKVYEDFST | FLVEYHLIWA | KRNDPSQTQG | 
    150:
    SKSKQIQWPA | LTFKPLVERN | IPSSVTAVEF | LVDKQLDFLT | EDSAFQPYQD | 
    200:
    DIDSLNPVLR | DNPQLHEEVK | VWVKEQKVQE | IFMQGPYSLN | GYRVRVYRQD | 
    250:
    SATQWFTGII | THHDLFTRTM | IVMNDQVLEP | QNVDPSMVQM | TFLDDVVHSL | 
    300:
    LKGENIGITS | RRRSRANQNV | NAVHSHYTRA | QANSPRPAMN | SQAAVPKQNT | 
    350:
    HQQQQQRSIR | PNKRKGSDSS | IPDEEKMKEE | KYDYISRGEN | PKGKNKHLMN | 
    400:
    KRRKPEEDEK | KLNMKRLRTD | NVSDFSESSD | SENSNKRIID | NSSEQKPENE | 
    450:
    LKNKNTSKIN | GEEGKPHNNE | KAGEETLKNS | QPPWDQIQED | KKHEEAEKRK | 
    500:
    SVDTQLQEDM | IIHSSEQSTV | SDHNSNDLLP | QECNMDKTHT | MELLPKEKFV | 
    550:
    SRPPTPKCVI | DITNDTNLEK | VAQENSSTFG | LQTLQKMDPN | VSDSKHSIAN | 
    600:
    AKFLETAKKD | SDQSWVSDVV | KVDLTQSSVT | NASSGNDHLN | MEKEKYVSYI | 
    650:
    SPLSAVSVME | DKLHKRSPPP | ETIKSKLNTS | VDTHKIKSSP | SPEVVKPKIT | 
    700:
    HSPDSVKSKA | TYVNSQATGE | RRLANKIEHE | LSRCSFHPIP | TRSSTLETTK | 
    750:
    SPLIIDKNEH | FTVYRDPALI | GSETGANHIS | PFLSQHPFPL | HSSSHRTCLN | 
    800:
    PGTHHPALTP | APHLLAGSSS | QTPLPTINTH | PLTSGPHHAV | HHPHLLPTVL | 
    850:
    PGVPTASLLG | GHPRLESAHA | SSLSHLALAH | QQQQQLLQHQ | SPHLLGQAHP | 
    900:
    SASYNQLGLY | PIIWQYPNGT | HAYSGLGLPS | SKWVHPENAV | NAEASLRRNS | 
    950:
    PSPWLHQPTP | VTSADGIGLL | SHIPVRPSSA | EPHRPLKITA | HSSPPLTKTL | 
    1000:
    VDHHKEELER | KAFMEPLRSV | ASTSAKNDLD | LNRSQTGKDC | HLHRHFVDPV | 
    1050:
    LNQLQRPPQE | TGERLNKYKE | EHRRILQESI | DVAPFTTKIK | GLEGERENYS | 
    1100:
    RVASSSSSPK | SHIIKQDMDV | ERSVSDLYKM | KHSVPQSLPQ | SNYFTTLSNS | 
    1150:
    VVNEPPRSYP | SKEVSNIYGD | KQSNALAAAA | ANPQTLTSFI | TSLSKPPPLI | 
    1200:
    KHQPESEGLV | GKIPEHLPHQ | IASHSVTTFR | NDCRSPTHLT | VSSTNTLRSM | 
    1250:
    PALHRAPVFH | PPIHHSLERK | EGSYSSLSPP | TLTPVMPVNA | GGKVQESQKP | 
    1300:
    PTLIPEPKDS | QANFKSSSEQ | SLTEMWRPNN | NLSKEKTEWH | VEKSSGKLQA | 
    1350:
    AMASVIVRPS | SSTKTDSMPA | MQLASKDRVS | ERSSAGAHKT | DCLKLAEAGE | 
    1400:
    TGRIILPNVN | SDSVHTKSEK | NFQAVSQGSV | PSSVMSAVNT | MCNTKTDVIT | 
    1450:
    SAADTTSVSS | WGGSEVISSL | SNTILASTSS | ECVSSKSVSQ | PVAQKQECKV | 
    1500:
    STTAPVTLAS | SKTGSVVQPS | SGFSGTTDFI | HLKKHKAALA | AAQYKSSNAS | 
    1550:
    ETEPNAIKNQ | TLSASLPLDS | TVICSTINKA | NSVGNGQASQ | TSQPNYHTKL | 
    1600:
    KKAWLTRHSE | EDKNTNKMEN | SGNSVSEIIK | PCSVNLIAST | SSDIQNSVDS | 
    1650:
    KIIVDKYVKD | DKVNRRKAKR | TYESGSESGD | SDESESKSEQ | RTKRQPKPTY | 
    1700:
    KKKQNDLQKR | KGEIEEDLKP | NGVLSRSAKE | RSKLKLQSNS | NTGIPRSVLK | 
    1750:
    DWRKVKKLKQ | TGESFLQDDS | CCEIGPNLQK | CRECRLIRSK | KGEEPAHSPV | 
    1800:
    FCRFYYFRRL | SFSKNGVVRI | DGFSSPDQYD | DEAMSLWTHE | NFEDDELDIE | 
    1850:
    TSKYILDIIG | DKFCQLVTSE | KTALSWVKKD | AKIAWKRAVR | GVREMCDACE | 
    1900:
    ATLFNIHWVC | QKCGFVVCLD | CYKAKERKSS | RDKELYAWMK | CVKGQPHDHK | 
    1950:
    HLMPTQIIPG | SVLTDLLDAM | HTLREKYGIK | SHCHCTNKQN | LQVGNFPTMN | 
    2000:
    GVSQVLQNVL | NHSNKISLCM | PESQQQNTPP | KSEKNGGSSP | ESDVGTDNKL | 
    2050:
    TPPESQSPLH | WLADLAEQKA | REEKKENKEL | TLENQIKEER | EQDNSESPNG | 
    2100:
    RTSPLVSQNN | EQGSTLRDLL | TTTAGKLRVG | STDAGIAFAP | VYSMGAPSSK | 
    2150:
    SGRTMPNILD | DIIASVVENK | IPPSKTSKIN | VKPELKEEPE | ESIISAVDEN | 
    2200:
    NKLYSDIPHS | WICEKHILWL | KDYKNSSNWK | LFKECWKQGQ | PAVVSGVHKK | 
    2250:
    MNISLWKAES | ISLDFGDHQA | DLLNCKDSII | SNANVKEFWD | GFEEVSKRQK | 
    2300:
    NKSGETVVLK | LKDWPSGEDF | KTMMPARYED | LLKSLPLPEY | CNPEGKFNLA | 
    2350:
    SHLPGFFVRP | DLGPRLCSAY | GVVAAKDHDI | GTTNLHIEVS | DVVNILVYVG | 
    2400:
    IAKGNGILSK | AGILKKFEEE | DLDDILRKRL | KDSSEIPGAL | WHIYAGKDVD | 
    2450:
    KIREFLQKIS | KEQGLEVLPE | HDPIRDQSWY | VNKKLRQRLL | EEYGVRTCTL | 
    2500:
    IQFLGDAIVL | PAGALHQVQN | FHSCIQVTED | FVSPEHLVES | FHLTQELRLL | 
    2540:
    KEEINYDDKL | QVKNILYHAV | KEMVRALKIH | EDEVEDMEEN | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    MIM:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Probable JmjC domain-containing histone demethylation protein 2C
    ELISA Kit for Human Probable JmjC domain-containing histone demethylation protein 2C
    CLIA Kit for Human Probable JmjC domain-containing histone demethylation protein 2C
    CLIA Kit for Human Probable JmjC domain-containing histone demethylation protein 2C
    Polyclonal Antibody for Human Probable JmjC domain-containing histone demethylation protein 2C
    Polyclonal Antibody for Human Probable JmjC domain-containing histone demethylation protein 2C
    Monoclonal Antibody for Human Probable JmjC domain-containing histone demethylation protein 2C
    Monoclonal Antibody for Human Probable JmjC domain-containing histone demethylation protein 2C
    Protein for Human Probable JmjC domain-containing histone demethylation protein 2C
    Protein for Human Probable JmjC domain-containing histone demethylation protein 2C

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR."
      Wolf S.S. , Patchev V.K. , Obendorf M.
      Arch. Biochem. Biophys.460:56-66(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-2540;VARIANTS THR-464 AND ASP-2535
      tissue: Amygdala.
      tissue: Cervix.
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-427
      tissue: Embryo.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
      DNA Res.7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1275-2540
      tissue: Brain.
    6. 6.
      "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
      Lee J.W. , Choi H.-S. , Gyuris J. , Brent R. , Moore D.D.
      Mol. Endocrinol.9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2030-2212;INTERACTION WITH THYROID RECEPTOR
    7. 7.
      "Identification and characterization of TRIP8 gene in silico."
      Katoh M. , Katoh M.
      Int. J. Mol. Med.12:817-821(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF THE GENE
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-376 AND SER-641;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 10.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-373; SER-617; SER-638; SER-641; SER-652 AND SER-1989;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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