MAPK8IP1 ELISA Kit for Human(Homo sapiens) | EIAab.comMAPK8IP1 ELISA Kit for Human(Homo sapiens)

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MAPK8IP1 (Gene name),

C-Jun-amino-terminal kinase-interacting protein 1 (Protein name ), JIP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

MAPK8IP1(IB1;JIP1;PRKM8IP);

Protein name:

C-Jun-amino-terminal kinase-interacting protein 1(JIP-1;JNK-interacting protein 1);

Alternative:

JNK MAP kinase scaffold protein 1;Islet-brain 1(IB-1);Mitogen-activated protein kinase 8-interacting protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely, MAPK8, MAPK9, MAPK10, MAPKK7, MLK2, MLK3, MAP3K12 and MAP3K13. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Interacts, via the PID domain, with RGNEF. Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of KNS2, then the pre-assembled MAPK8IP1 scaffolding complexes are transported as a cargo of kinesin, to the required subcellular location. Interacts with the cytoplasmic domain of APP (By similarity). Interacts with MAP3K7. Interacts with isoform 1 and isoform 2 of VRK2.

Function:

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.

Subcellular Location:

Cytoplasm Cytoplasm perinuclear region Nucleus Endoplasmic reticulum membrane Mitochondrion membrane Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus.

Protein Attributes:

Sequence length:

711

Sequence:

50:

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350:

400:

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650:

700:

711:

YTCPTEDIYL | E

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:9479

Pfam:

PF00640

String:

Q9UQF2

MIM:

125853

UniGene:

Hs.234249

STRING:

9606.ENSP00000241014

SMR:

Q9UQF2

Uniprot:

Q9UQF2

FOR

ELISA Kit for Human JIP-1

CLIA Kit for Human JIP-1

Polyclonal Antibody for Human JIP-1

Monoclonal Antibody for Human JIP-1

Protein for Human JIP-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/C-jun-amino-terminal kinase interacting protein-1 (JIP-1) gene."
Mooser V. , Maillard A. , Bonny C. , Steinmann M. , Shaw P. , Yarnall D.P. , Burns D.K. , Schorderet D.F. , Nicod P. , Waeber G.
Genomics55:202-208(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Insulinoma.
2.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

Yu W. , Sarginson J. , Gibbs R.A.
Submitted (1997-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 468-711
tissue: Brain.
4.

"Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons."
Meyer D. , Liu A. , Margolis B.
J. Biol. Chem.274:35113-35118(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGEF28;SUBCELLULAR LOCATION
5.

"Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules."
Verhey K.J. , Meyer D. , Deehan R. , Blenis J. , Schnapp B.J. , Rapoport T.A. , Margolis B.
J. Cell Biol.152:959-970(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS;INTERACTION WITH KINESIN
6.

"Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway."
Ikeda A. , Hasegawa K. , Masaki M. , Moriguchi T. , Nishida E. , Kozutsumi Y. , Oka S. , Kawasaki T.
J. Biochem.130:773-781(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K13
7.

"Interaction of Alzheimer's beta-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade."
Taru H. , Iijima K. , Hase M. , Kirino Y. , Yagi Y. , Suzuki T.
J. Biol. Chem.277:20070-20078(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APP
8.

"Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation."
Nihalani D. , Wong H.N. , Holzman L.B.
J. Biol. Chem.278:28694-28702(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-103 AND THR-205;MUTAGENESIS OF ARG-160 AND PRO-161
9.

"Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death."
Bonny C. , Oberson A. , Negri S. , Sauser C. , Schorderet D.F.
Diabetes50:77-82(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PEPTIDE INHIBITORS OF JNK
10.

"Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1."
Allaman-Pillet N. , Storling J. , Oberson A. , Roduit R. , Negri S. , Sauser C. , Nicod P. , Beckmann J.S. , Schorderet D.F. , Mandrup-Poulsen T. , Bonny C.
J. Biol. Chem.278:48720-48726(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CALCIUM- AND PROTEASOME-DEPENDENT DEGRADATION
11.

"A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia."
Borsello T. , Clarke P.G. , Hirt L. , Vercelli A. , Repici M. , Schorderet D.F. , Bogousslavsky J. , Bonny C.
Nat. Med.9:1180-1186(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTECTION AGAINST EXCITOTOXICITY AND CEREBRAL ISCHEMIA
12.

"Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease."
D'Ambrosio C. , Arena S. , Fulcoli G. , Scheinfeld M.H. , Zhou D. , D'Adamio L. , Scaloni A.
Mol. Cell. Proteomics5:97-113(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-40; SER-181; SER-187; SER-193; SER-195; SER-196; SER-214; SER-311; SER-328; SER-330; SER-340; SER-355; SER-366; SER-369; SER-407; SER-409; THR-411; SER-444; SER-447; SER-444; THR-448; SER-469; SER-471; SER-472 AND SER-473
13.

"Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1."
Blanco S. , Santos C. , Lazo P.A.
Mol. Cell. Biol.27:7273-7283(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K7
14.

"Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein."
Blanco S. , Sanz-Garcia M. , Santos C.R. , Lazo P.A.
PLoS ONE3:E1660-E1660(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH VRK2;PHOSPHORYLATION
15.

"The gene, MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes."
Waeber G. , Delplanque J. , Bonny C. , Mooser V. , Steinmann M. , Widmann C. , Maillard A. , Miklossy J. , Dina C. , Hani E.H. , Vionnet N. , Nicod P. , Boutin P. , Froguel P.
Nat. Genet.24:291-295(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NIDDM ASN-59

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