Mapk8ip1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comMapk8ip1 ELISA Kit for Rat(Rattus norvegicus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Mapk8ip1(Gene name) > Rat

Mapk8ip1 (Gene name),

C-Jun-amino-terminal kinase-interacting protein 1 (Protein name ), JIP1_RAT from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Mapk8ip1(Ib1;Jip1;Mapk8ip);

Protein name:

C-Jun-amino-terminal kinase-interacting protein 1(JIP-1;JNK-interacting protein 1);

Alternative:

JIP-1-related protein(JRP);Islet-brain-1(IB-1);Mitogen-activated protein kinase 8-interacting protein 1;JNK MAP kinase scaffold protein 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely MAPK8, MAPK9, MAPK10, MAP2K7, MAP3K10, MAP3K11 and DLK1. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Interacts, via the PID domain, with RGNEF (By similarity). Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Interacts with the cytoplasmic domain of APP (By similarity). Interacts with VRK2 and MAP3K7.

Function:

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.

Subcellular Location:

Cytoplasm Cytoplasm perinuclear region Nucleus Endoplasmic reticulum membrane Mitochondrion membrane Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus.

Protein Attributes:

Sequence length:

708

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

708:

PTEDIYLE

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

Q9R237

KEGG:

rno:116457

Pfam:

PF00640

String:

Q9R237

UniGene:

Rn.44266

STRING:

10116.ENSRNOP00000009725

Uniprot:

Q9R237

FOR

ELISA Kit for Rat JIP-1

CLIA Kit for Rat JIP-1

Polyclonal Antibody for Rat JIP-1

Monoclonal Antibody for Rat JIP-1

Protein for Rat JIP-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"IB1, a JIP-1-related nuclear protein present in insulin-secreting cells."
Bonny C. , Nicod P. , Waeber G.
J. Biol. Chem.273:1843-1846(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Pancreas.
2.

"JIP-1 related protein (JRP)."
Chen Y. , Talmage D.
Submitted (1998-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
strain: Fischer.
tissue: Fibroblast.
3.

"Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brain."
Kim I.-J. , Lee K.-W. , Park B.Y. , Lee J.-K. , Park J. , Choi I.Y. , Eom S.-J. , Chang T.-S. , Kim M.J. , Yeom Y.I. , Chang S.K. , Lee Y.-D. , Choi E.-J. , Han P.-L.
J. Neurochem.72:1335-1343(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
strain: Sprague-Dawley.
tissue: Brain.
4.

"A unique set of SH3-SH3 interactions controls IB1 homodimerization."
Kristensen O. , Guenat S. , Dar I. , Allaman-Pillet N. , Abderrahmani A. , Ferdaoussi M. , Roduit R. , Maurer F. , Beckmann J.S. , Kastrup J.S. , Gajhede M. , Bonny C.
EMBO J.25:785-797(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 487-546;SH3 DOMAIN;SUBUNIT

Product Feedback Wall

* Email:
*Comments: