MAPK8IP2 ELISA Kit for Human(Homo sapiens) | EIAab.comMAPK8IP2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MAPK8IP2(Gene name) > Human

MAPK8IP2 (Gene name),

C-Jun-amino-terminal kinase-interacting protein 2 (Protein name ), JIP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

MAPK8IP2(IB2;JIP2;PRKM8IPL);

Protein name:

C-Jun-amino-terminal kinase-interacting protein 2(JIP-2;JNK-interacting protein 2);

Alternative:

JNK MAP kinase scaffold protein 2;Islet-brain-2(IB-2);Mitogen-activated protein kinase 8-interacting protein 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK, MAPKK7 and MLK2, MLK3 and DLK. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, Klc1, pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (By similarity). Interacts with the cytoplasmic domain of APP.

Function:

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins.

Subcellular Location:

Cytoplasm Accumulates in cell surface projections.

Protein Attributes:

Sequence length:

824

Sequence:

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