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Index > Protein center > Mapk8ip2(Gene name) > Mouse
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  • Mapk8ip2 (Gene name),
  • C-Jun-amino-terminal kinase-interacting protein 2 (Protein name ),  JIP2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Mapk8ip2(Ib2;Jip2);
    Protein name:
    C-Jun-amino-terminal kinase-interacting protein 2(JIP-2;JNK-interacting protein 2);
    Alternative:
    JNK MAP kinase scaffold protein 2;Islet-brain-2(IB-2);Mitogen-activated protein kinase 8-interacting protein 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms homo-or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK, MAPKK7 and MLK2, MLK3 and DLK (By similarity). Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the TPR motif-containing C-terminal of kinesin light chain. Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin).
    Function:
    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells.
    Subcellular Location:
    Cytoplasm Accumulates in cell surface projections.
    Protein Attributes:
    Sequence length:
    830
    Sequence:
    50:
    MADRAEMFSL | STFHSLSPPG | CRPPQDISLE | EFDDEDLSEI | TDDCGLGLSY | 
    100:
    DSDHCEKDSL | SLGRSEQPHP | ICSFQDDFQE | FEMIDDNEEE | DDEEEEEEEE | 
    150:
    EEEDGDRQGK | AGGGPGSQAL | AGDSLIPSPS | LEESHKLRPT | TLHLTTLGAQ | 
    200:
    DSLNNNNGGF | TSAPPSSWQE | TVLRSPAQEP | LKELPAPLLP | AEEERHEVQS | 
    250:
    LARPGCDCEG | NQPPEPPASS | GGASPSSDPG | IEADLRSHSS | GGHEGRRSSQ | 
    300:
    ELSSPGSDSE | DAGGARLGRM | ISSISETELE | LSSDGGSSSG | RSSHLTNSIE | 
    350:
    EASSPASEPE | PEPEPLHEPP | RRPAFLPVGQ | DDTNSEYESG | SESEPDLSED | 
    400:
    ADSPWLLSNL | VSRMISEGSS | PIRCPGQCLS | PAPRLPEEAA | SQANSVPQDC | 
    450:
    QDPEAGPHVE | LVDMDTLCGP | PPPAPAAPRL | GPAQPGPCLF | LSNPTRDTIT | 
    500:
    PLWATPGRTA | RPGRSCSAAC | SEEEEEDEEE | DEEDEEDAED | SVVPPGSRTT | 
    550:
    GSTAPLDASL | VYDAVKYTLV | VDEHTQLELV | SLRRCAGLGN | DSEEDSSCEA | 
    600:
    SEEEAGATLL | GSDQVPEDAS | PDSPDLTFSK | KFLNVFVNST | SRSSSTESFG | 
    650:
    LFSCVVNGEE | REQTHRAVFR | FIPRHPDELE | LDVDDPVLVE | AEEDDFWFRG | 
    700:
    FNMRTGERGV | FPAFYAHAVP | GPAKDLLGSK | RSPCWVDRFD | VQFLGSVEVP | 
    750:
    CHQGNGILCA | AMQKIATARK | LTVHLRPPAS | CDLEISLRGV | KLSLSGGGPE | 
    800:
    FQRCSHFFQM | KNISFCGCHP | RNSCYFGFIT | KHPLLSRFAC | HVFVSQESMR | 
    830:
    PVARSVGRAF | LEYYQEHLAF | ACPTEDIYLE | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse JIP-2
    ELISA Kit for Mouse JIP-2
    CLIA Kit for Mouse JIP-2
    CLIA Kit for Mouse JIP-2
    Polyclonal Antibody for Mouse JIP-2
    Polyclonal Antibody for Mouse JIP-2
    Monoclonal Antibody for Mouse JIP-2
    Monoclonal Antibody for Mouse JIP-2
    Protein for Mouse JIP-2
    Protein for Mouse JIP-2

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2."
      Stockinger W. , Brandes C. , Fasching D. , Hermann M. , Gotthardt M. , Herz J. , Schneider W.J. , Nimpf J.
      J. Biol. Chem.275:25625-25632(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH APOER2
      strain: BALB/c.
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryonic head.
    3. 3.
      "Fibroblast growth factor homologous factors are intracellular signaling proteins."
      Schoorlemmer J. , Goldfarb M.
      Curr. Biol.11:793-797(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF13 AND MAPK13
    4. 4.
      "Common and divergent roles for members of the mouse DCX superfamily."
      Coquelle F.M. , Levy T. , Bergmann S. , Wolf S.G. , Bar-El D. , Sapir T. , Brody Y. , Orr I. , Barkai N. , Eichele G. , Reiner O.
      Cell Cycle5:976-983(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DCLK2
    5. 5.
      "The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module."
      Terawaki S. , Kitano K. , Mori T. , Zhai Y. , Higuchi Y. , Itoh N. , Watanabe T. , Kaibuchi K. , Hakoshima T.
      EMBO J.29:236-250(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TIAM1 AND TIAM2
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