MAPK8IP3 ELISA Kit for Human(Homo sapiens) | EIAab.comMAPK8IP3 ELISA Kit for Human(Homo sapiens) | EIAab.com

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MAPK8IP3 (Gene name),

C-Jun-amino-terminal kinase-interacting protein 3 (Protein name ), JIP3_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

MAPK8IP3(JIP3;KIAA1066);

Protein name:

C-Jun-amino-terminal kinase-interacting protein 3(JIP-3;JNK-interacting protein 3);

Alternative:

Mitogen-activated protein kinase 8-interacting protein 3;JNK MAP kinase scaffold protein 3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal of MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8, MAPK9 and MAPK10 to the N-terminal region, MAP2K4 and MAP2K7 to the central region and MAP3K11 to the C-terminal region. Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (By similarity). Interacts with ROCK1 and this interaction is enhanced by ultraviolet-B (UVB) radiation.

Function:

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1336

Sequence:

50:

MMEIQMDEGG | GVVVYQDDYC | SGSVMSERVS | GLAGSIYREF | ERLIHCYDEE |

100:

VVKELMPLVV | NVLENLDSVL | SENQEHEVEL | ELLREDNEQL | LTQYEREKAL |

150:

RRQAEEKFIE | FEDALEQEKK | ELQIQVEHYE | FQTRQLELKA | KNYADQISRL |

200:

EERESEMKKE | YNALHQRHTE | MIQTYVEHIE | RSKMQQVGGN | SQTESSLPGR |

250:

RKERPTSLNV | FPLADGTVRA | QIGGKLVPAG | DHWHLSDLGQ | LQSSSSYQCP |

300:

QDEMSESGQS | SAAATPSTTG | TKSNTPTSSV | PSAAVTPLNE | SLQPLGDYGV |

350:

GSKNSKRARE | KRDSRNMEVQ | VTQEMRNVSI | GMGSSDEWSD | VQDIIDSTPE |

400:

LDMCPETRLD | RTGSSPTQGI | VNKAFGINTD | SLYHELSTAG | SEVIGDVDEG |

450:

ADLLGEFSVR | DDFFGMGKEV | GNLLLENSQL | LETKNALNVV | KNDLIAKVDQ |

500:

LSGEQEVLRG | ELEAAKQAKV | KLENRIKELE | EELKRVKSEA | IIARREPKEE |

550:

AEDVSSYLCT | ESDKIPMAQR | RRFTRVEMAR | VLMERNQYKE | RLMELQEAVR |

600:

WTEMIRASRE | HPSVQEKKKS | TIWQFFSRLF | SSSSSPPPAK | RPYPSVNIHY |

650:

KSPTTAGFSQ | RRNHAMCPIS | AGSRPLEFFP | DDDCTSSARR | EQKREQYRQV |

700:

REHVRNDDGR | LQACGWSLPA | KYKQLSPNGG | QEDTRMKNVP | VPVYCRPLVE |

750:

KDPTMKLWCA | AGVNLSGWRP | NEDDAGNGVK | PAPGRDPLTC | DREGDGEPKS |

800:

AHTSPEKKKA | KELPEMDATS | SRVWILTSTL | TTSKVVIIDA | NQPGTVVDQF |

850:

TVCNAHVLCI | SSIPAASDSD | YPPGEMFLDS | DVNPEDPGAD | GVLAGITLVG |

900:

CATRCNVPRS | NCSSRGDTPV | LDKGQGEVAT | IANGKVNPSQ | STEEATEATE |

950:

VPDPGPSEPE | TATLRPGPLT | EHVFTDPAPT | PSSGPQPGSE | NGPEPDSSST |

1000:

RPEPEPSGDP | TGAGSSAAPT | MWLGAQNGWL | YVHSAVANWK | KCLHSIKLKD |

1050:

SVLSLVHVKG | RVLVALADGT | LAIFHRGEDG | QWDLSNYHLM | DLGHPHHSIR |

1100:

CMAVVYDRVW | CGYKNKVHVI | QPKTMQIEKS | FDAHPRRESQ | VRQLAWIGDG |

1150:

VWVSIRLDST | LRLYHAHTHQ | HLQDVDIEPY | VSKMLGTGKL | GFSFVRITAL |

1200:

LVAGSRLWVG | TGNGVVISIP | LTETVVLHRG | QLLGLRANKT | SPTSGEGARP |

1250:

GGIIHVYGDD | SSDRAASSFI | PYCSMAQAQL | CFHGHRDAVK | FFVSVPGNVL |

1300:

ATLNGSVLDS | PAEGPGPAAP | ASEVEGQKLR | NVLVLSGGEG | YIDFRIGDGE |

1336:

DDETEEGAGD | MSQVKPVLSK | AERSHIIVWQ | VSYTPE

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

String:

MIM:

Pfam:

KEGG:

SMR:

UniGene:

STRING:

9606.ENSP00000250894

Uniprot:

FOR

ELISA Kit for Human JIP-3

ELISA Kit for Human JIP-3

CLIA Kit for Human JIP-3

CLIA Kit for Human JIP-3

Polyclonal Antibody for Human JIP-3

Polyclonal Antibody for Human JIP-3

Monoclonal Antibody for Human JIP-3

Monoclonal Antibody for Human JIP-3

Protein for Human JIP-3

Protein for Human JIP-3

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R. , Nagase T. , Ishikawa K. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.6:197-205(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
2.

Ohara O. , Nagase T. , Kikuno R.
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 324; 414 AND 753
3.

"Characterization of long cDNA clones from human adult spleen."
Hattori A. , Okumura K. , Nagase T. , Kikuno R. , Hirosawa M. , Ohara O.
DNA Res.7:357-366(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Spleen.
4.

"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J. , Peden J.F. , Lloyd C. , Horsley S.W. , Clark K. , Tufarelli C. , Kearney L. , Buckle V.J. , Doggett N.A. , Flint J. , Higgs D.R.
Hum. Mol. Genet.10:339-352(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
7.

"Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade."
Matsuura H. , Nishitoh H. , Takeda K. , Matsuzawa A. , Amagasa T. , Ito M. , Yoshioka K. , Ichijo H.
J. Biol. Chem.277:40703-40709(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP2K4/MEK4; MAP2K7/MKK7; MAPK10/JNK3 AND MAP3K5/ASK1;FUNCTION
8.

"Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage."
Ongusaha P.P. , Qi H.H. , Raj L. , Kim Y.B. , Aaronson S.A. , Davis R.J. , Shi Y. , Liao J.K. , Lee S.W.
Sci. Signal.1:RA14-RA14(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ROCK1;PHOSPHORYLATION AT SER-314; SER-364 AND SER-365

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