Mapk8ip3 ELISA Kit for Mouse(Mus musculus) | EIAab.comMapk8ip3 ELISA Kit for Mouse(Mus musculus)

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Mapk8ip3 (Gene name),

C-Jun-amino-terminal kinase-interacting protein 3 (Protein name ), JIP3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mapk8ip3(Jip3;Jsap1;Syd2);

Protein name:

C-Jun-amino-terminal kinase-interacting protein 3(JIP-3;JNK-interacting protein 3);

Alternative:

JNK/SAPK-associated protein 1(JSAP1);JNK MAP kinase scaffold protein 3;Sunday driver 2;Mitogen-activated protein kinase 8-interacting protein 3;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal of MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8, MAPK9 and MAPK10 to the N-terminal region, MAP2K4 and MAP2K7 to the central region and MAP3K11 to the C-terminal region. Binds the TPR motif-containing C-terminal of kinesin light chain, pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Interacts with ROCK1 and this interaction is enhanced by ultraviolet-B (UVB) radiation.

Function:

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins.

Subcellular Location:

Cytoplasm Golgi apparatus Cytoplasmic vesicle Cell projection growth cone Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells.

Protein Attributes:

Sequence length:

1337

Sequence:

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1337:

EDDETEECAG | DVNQTKPSLS | KAERSHIIVW | QVSYTPE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF09744

KEGG:

mmu:30957

SMR:

Q9ESN9

String:

Q9ESN9

UniGene:

Mm.43081

Uniprot:

Q9ESN9

FOR

ELISA Kit for Mouse JIP-3

CLIA Kit for Mouse JIP-3

Polyclonal Antibody for Mouse JIP-3

Monoclonal Antibody for Mouse JIP-3

Protein for Mouse JIP-3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a scaffold factor in the JNK signaling pathway."
Ito M. , Yoshioka K. , Akechi M. , Yamashita S. , Takamatsu N. , Sugiyama K. , Hibi M. , Nakabeppu Y. , Shiba T. , Yamamoto K.
Mol. Cell. Biol.19:7539-7548(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A);FUNCTION;PHOSPHORYLATION;INTERACTION WITH MAPK8; MAPK9; MAPK10; MAP2K4 AND MAP3K1
tissue: Brain.
2.

"Isoforms of JSAP1 scaffold protein generated through alternative splicing."
Ito M. , Akechi M. , Hirose R. , Ichimura M. , Takamatsu N. , Xu P. , Nakabeppu Y. , Tadayoshi S. , Yamamoto K. , Yoshioka K.
Gene255:229-234(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1A; 1B; 1C; 1D AND 1E);TISSUE SPECIFICITY
tissue: Brain.
3.

"Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3."
Kelkar N. , Gupta S. , Dickens M. , Davis R.J.
Mol. Cell. Biol.20:1030-1043(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1C AND 3A);FUNCTION;INDUCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;PHOSPHORYLATION AT THR-266; THR-276 AND THR-287;MUTAGENESIS OF ARG-205; PRO-206; THR-207; SER-208; LEU-209; THR-266; THR-276 AND THR-287;INTERACTION WITH MAPK8IP2; MAPK8; MAPK9; MAPK10; MAP2K7 AND MAP3K11
strain: C57BL/6.
tissue: Brain.
tissue: Heart.
4.

"Kinesin-dependent axonal transport is mediated by the Sunday Driver (SYD) protein."
Bowman A.B. , Kamal A. , Ritchings B.W. , Philp A.V. , McGrail M. , Gindhart J.G. , Goldstein L.S.B.
Cell103:583-594(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1C);SUBCELLULAR LOCATION;INTERACTION WITH KLC1
strain: C57BL/6.
tissue: Brain.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1B);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1240-1337 (ISOFORM 1C)
strain: C57BL/6.
tissue: Brain.
6.

"Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules."
Verhey K.J. , Meyer D. , Deehan R. , Blenis J. , Schnapp B.J. , Rapoport T.A. , Margolis B.
J. Cell Biol.152:959-970(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLC
tissue: Brain.
7.

"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-677;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.

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