JMY ELISA Kit for Human(Homo sapiens) | EIAab.comJMY ELISA Kit for Human(Homo sapiens)

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Index > Protein center > JMY(Gene name) > Human

JMY (Gene name),

Junction-mediating and -regulatory protein (Protein name ), JMY_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

JMY;

Protein name:

Junction-mediating and -regulatory protein;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5.

Function:

Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.

Subcellular Location:

Nucleus Cytoplasm cytoskeleton Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells.

Protein Attributes:

Sequence length:

988

Sequence:

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