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Index > Protein center > JOSD2(Gene name) > Human
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  • JOSD2 (Gene name),
  • Josephin-2 (Protein name ),  JOS2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    JOSD2(SBBI54);
    Protein name:
    Josephin-2;
    Alternative:
    Josephin domain-containing protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    188
    Sequence:
    50:
    MSQAPGAQPS | PPTVYHERQR | LELCAVHALN | NVLQQQLFSQ | EAADEICKRL | 
    100:
    APDSRLNPHR | SLLGTGNYDV | NVIMAALQGL | GLAAVWWDRR | RPLSQLALPQ | 
    150:
    VLGLILNLPS | PVSLGLLSLP | LRRRHWVALR | QVDGVYYNLD | SKLRAPEALG | 
    188:
    DEDGVRAFLA | AALAQGLCEV | LLVVTKEVEE | KGSWLRTD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Josephin-2
    ELISA Kit for Human Josephin-2
    CLIA Kit for Human Josephin-2
    CLIA Kit for Human Josephin-2
    Polyclonal Antibody for Human Josephin-2
    Polyclonal Antibody for Human Josephin-2
    Monoclonal Antibody for Human Josephin-2
    Monoclonal Antibody for Human Josephin-2
    Protein for Human Josephin-2
    Protein for Human Josephin-2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Hypothetical transmembrane protein SBBI54."
      Li N. , Wan T. , Zhang W. , Cao X.
      Submitted (2000-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Macrophage.
    3. 3.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Uterus.
    6. 6.
      "Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes."
      Tzvetkov N. , Breuer P.
      Biol. Chem.388:973-978(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION
    7. 7.
      "Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity."
      Weeks S.D. , Grasty K.C. , Hernandez-Cuebas L. , Loll P.J.
      J. Biol. Chem.286:4555-4565(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION
    8. 8.
      "JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis."
      Seki T. , Gong L. , Williams A.J. , Sakai N. , Todi S.V. , Paulson H.L.
      J. Biol. Chem.288:17145-17155(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-24
    9. 9.
      "Structural modeling of ataxin-3 reveals distant homology to adaptins."
      Albrecht M. , Hoffmann D. , Evert B.O. , Schmitt I. , Wuellner U. , Lengauer T.
      Proteins50:355-370(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
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