Gene name:
JPH1 (JP1;MG72) ;
Protein name:
Junctophilin-1 (JP-1) ;
Alternative:
Mitsugumin-72 (Mg72) ;Junctophilin type 1 ;
Organism:
Rabbit (Oryctolagus cuniculus).
General Annotation
Function:
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Endoplasmic reticulum membrane
Single-pass type IV membrane protein
Sarcoplasmic reticulum membrane
Single-pass type IV membrane protein
Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands.
Protein Attributes:
50:
MTGGRFDFDD | GGTYCGGWEE | GKAHGHGICT | GPKGQGEYSG | SWSHGFEVVG |
100:
GYTWPSGNTY | QGYWAQGKRH | GLGVETKGKW | MYRGEWSHGF | KGRYGVRQSL |
150:
CTPARYEGTW | SNGLQDGYGV | ETYGDGGTYQ | GQWAGGMRHG | YGVRQSVPYG |
200:
MATVIRSPLR | TSLASLRSEQ | SNGSVLHDAA | AAADTPTGTR | GGFVLNFHAD |
250:
AELAGKKKGG | LFRRGSLLGS | MKLRKSESKS | SISSKRSSVR | SDAAMSRISS |
300:
SDANSTISFG | DVDCDFCPVE | DHVDATTTET | YMGEWKNDKR | NGFGISERSN |
350:
GMKYEGEWAN | NKRHGYGCTV | FPDGSKEEGK | YKNNILVRGI | RKQLIPIRNT |
400:
KTREKVDRAI | EGAQRAAAMA | RTKVEIANSR | TAHARAKADA | ADQAALAARQ |
450:
ECDIARAVAR | ELSPDFYQPG | PDYIKQRLQE | GVDAKENPEE | KVPAKPPTPK |
500:
ESPHFYRKGT | TPPGSPEASP | KYSRSPQPSP | PKPAKKQNPS | SGARLNQDKR |
550:
GVAEEQVTAI | VNKPLTSKAP | TKEVGAAVSQ | SKYSGRHHVP | NPSNGELHSQ |
600:
YHGYYVKLHA | PQHPPVDAED | DDRSSPSSSA | LVHKPSPNKW | SPPKSVTKPV |
650:
AKESKAEPKA | KKSELAIPKN | PASNDSCPSM | EREANSGPNS | VMIVLVMLLN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rabbit
Mouse
ELISA Kit for Rabbit JP-1
ELISA Kit for Rabbit JP-1
ELISA Kit for Rabbit JP-1
Polyclonal Antibody for Rabbit JP-1
Polyclonal Antibody for Rabbit JP-1
Polyclonal Antibody for Rabbit JP-1
Monoclonal Antibody for Rabbit JP-1
Monoclonal Antibody for Rabbit JP-1
Monoclonal Antibody for Rabbit JP-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Skeletal muscle .