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Index > Protein center > Jph2(Gene name) > Mouse
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  • Jph2 (Gene name),
  • Junctophilin-2 (Protein name ),  JPH2_MOUSE from NCBI database.
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  • Gene name:
    Jph2(Jp2);
    Protein name:
    Junctophilin-2(JP-2);
    Alternative:
    Junctophilin type 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Endoplasmic reticulum membrane Single-pass type IV membrane protein Sarcoplasmic reticulum membrane Single-pass type IV membrane protein Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands.
    Protein Attributes:
    Sequence length:
    696
    Sequence:
    50:
    MSGGRFDFDD | GGAYCGGWEG | GKAHGHGLCT | GPKGQGEYSG | SWNFGFEVAG | 
    100:
    VYTWPSGNTF | EGYWSQGKRH | GLGIETKGRW | LYKGEWTHGF | KGRYGIRQST | 
    150:
    NSGAKYEGTW | NNGLQDGYGT | ETYADGGTYQ | GQFTNGMRHG | YGVRQSVPYG | 
    200:
    MAVVVRSPLR | TSLSSLRSEH | SNGTVAPDSP | AADGPMLPSP | PVPRGGFALT | 
    250:
    LLATAEAARP | QGLFTRGTLL | GRLRRSESRT | SLGSQRSRLS | FLKSELSSGA | 
    300:
    SDAASTGSLA | EGAEGPDDAA | APFDADIDAT | TTETYMGEWK | NDKRSGFGVS | 
    350:
    ERSSGLRYEG | EWLDNLRHGY | GRTTLPDGHR | EEGKYRHNVL | VKGTKRRVLP | 
    400:
    LKSSKVRQKV | EHGVEGAQRA | AAIARQKAEI | AASRTSHAKA | KAEAAEQAAL | 
    450:
    AANQESNIAR | TLAKELAPDF | YQPGPEYQKR | RLLQEILENS | ESLLEPPERG | 
    500:
    LGTGLPERPR | ESPQLHERET | PQPEGGPPSP | AGTPPQPKRP | RPGASKDGLL | 
    550:
    SPGSWNGEPG | GEGSRPATPS | DGAGRRSPAR | PASEHMAIEA | LQPPPAPSQE | 
    600:
    PEVAMYRGYH | SYAVRTGPPE | PPPLEDEQEP | EPEPEPEVRR | SDSAPPSPVS | 
    650:
    ATVPEEEPPA | PRSPVPAKQA | TLEPKPIVPK | AEPKAKARKT | EARGLSKAGA | 
    696:
    KKKGRKEVAQ | AKEAEVEVEE | VPNTVLICMV | ILLNIGLAIL | FVHLLT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse JP-2
    ELISA Kit for Mouse JP-2
    ELISA Kit for Mouse JP-2
    ELISA Kit for Mouse JP-2
    CLIA Kit for Mouse JP-2
    CLIA Kit for Mouse JP-2
    CLIA Kit for Mouse JP-2
    CLIA Kit for Mouse JP-2
    Polyclonal Antibody for Mouse JP-2
    Polyclonal Antibody for Mouse JP-2
    Polyclonal Antibody for Mouse JP-2
    Polyclonal Antibody for Mouse JP-2
    Monoclonal Antibody for Mouse JP-2
    Monoclonal Antibody for Mouse JP-2
    Monoclonal Antibody for Mouse JP-2
    Monoclonal Antibody for Mouse JP-2
    Protein for Mouse JP-2
    Protein for Mouse JP-2
    Protein for Mouse JP-2
    Protein for Mouse JP-2

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    References
    1. 1.
      "Junctophilins: a novel family of junctional membrane complex proteins."
      Takeshima H. , Komazaki S. , Nishi M. , Iino M. , Kangawa K.
      Mol. Cell6:11-22(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;FUNCTION
      strain: 129.
      strain: C57BL/6J.
      tissue: Heart.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NOD.
      tissue: Spleen.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes."
      Yamazaki D. , Yamazaki T. , Takeshima H.
      Pharmacol. Ther.121:265-272(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
    5. 5.
      "Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice."
      van Oort R.J. , Garbino A. , Wang W. , Dixit S.S. , Landstrom A.P. , Gaur N. , De Almeida A.C. , Skapura D.G. , Rudy Y. , Burns A.R. , Ackerman M.J. , Wehrens X.H.
      Circulation123:979-988(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
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