JPH2 ELISA Kit for Rabbit(Oryctolagus cuniculus) | EIAab.comJPH2 ELISA Kit for Rabbit(Oryctolagus cuniculus)

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Index > Protein center > JPH2(Gene name) > Rabbit

JPH2 (Gene name),

Junctophilin-2 (Protein name ), JPH2_RABIT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

JPH2(JP2);

Protein name:

Junctophilin-2(JP-2);

Alternative:

Junctophilin type 2;

Organism:

Rabbit (Oryctolagus cuniculus).

General Annotation

Sub Unit:

N/A

Function:

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.

Subcellular Location:

Cell membrane Peripheral membrane protein Endoplasmic reticulum membrane Single-pass type IV membrane protein Sarcoplasmic reticulum membrane Single-pass type IV membrane protein Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands.

Protein Attributes:

Sequence length:

694

Sequence:

50:

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450:

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650:

694:

KPRKEAAQAA | EAEVEVEEVP | NTVLICMVIL | LNIGLAILFV | HLLT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9GKY7

STRING:

9986.ENSOCUP00000019570

UniGene:

Ocu.2521

Pfam:

PF02493

Uniprot:

Q9GKY7

FOR

ELISA Kit for Rabbit JP-2

CLIA Kit for Rabbit JP-2

Polyclonal Antibody for Rabbit JP-2

Monoclonal Antibody for Rabbit JP-2

Protein for Rabbit JP-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Structure, distribution and gene mapping of junctophilin/mitsugumin72 subtypes."
Takeshima H.
Submitted (1999-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Heart.

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