JPH3 ELISA Kit for Human(Homo sapiens) | EIAab.comJPH3 ELISA Kit for Human(Homo sapiens) | EIAab.com

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JPH3 (Gene name),

Junctophilin-3 (Protein name ), JPH3_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

JPH3(JP3;TNRC22);

Protein name:

Junctophilin-3(JP-3);

Alternative:

Trinucleotide repeat-containing gene 22 protein;Junctophilin type 3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.

Subcellular Location:

Cell membrane Peripheral membrane protein Endoplasmic reticulum membrane Single-pass type IV membrane protein Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane.

Protein Attributes:

Sequence length:

748

Sequence:

50:

MSSGGRFNFD | DGGSYCGGWE | DGKAHGHGVC | TGPKGQGEYT | GSWSHGFEVL |

100:

GVYTWPSGNT | YQGTWAQGKR | HGIGLESKGK | WVYKGEWTHG | FKGRYGVREC |

150:

AGNGAKYEGT | WSNGLQDGYG | TETYSDGGTY | QGQWVGGMRQ | GYGVRQSVPY |

200:

GMAAVIRSPL | RTSINSLRSE | HTNGTALHPD | ASPAVAGSPA | VSRGGFVLVA |

250:

HSDSEILKSK | KKGLFRRSLL | SGLKLRKSES | KSSLASQRSK | QSSFRSEAGM |

300:

STVSSTASDI | HSTISLGEAE | AELAVIEDDI | DATTTETYVG | EWKNDKRSGF |

350:

GVSQRSDGLK | YEGEWASNRR | HGYGCMTFPD | GTKEEGKYKQ | NILVGGKRKN |

400:

LIPLRASKIR | EKVDRAVEAA | ERAATIAKQK | AEIAASRTSH | SRAKAEAALT |

450:

AAQKAQEEAR | IARITAKEFS | PSFQHRENGL | EYQRPKRQTS | CDDIEVLSTG |

500:

TPLQQESPEL | YRKGTTPSDL | TPDDSPLQSF | PTSPAATPPP | APAARNKVAH |

550:

FSRQVSVDEE | RGGDIQMLLE | GRAGDCARSS | WGEEQAGGSR | GVRSGALRGG |

600:

LLVDDFRTRG | SGRKQPGNPK | PRERRTESPP | VFTWTSHHRA | SNHSPGGSRL |

650:

LELQEEKLSN | YRMEMKPLLR | METHPQKRRY | SKGGACRGLG | DDHRPEDRGF |

700:

GVQRLRSKAQ | NKENFRPASS | AEPAVQKLAS | LRLGGAEPRL | LRWDLTFSPP |

748:

QKSLPVALES | DEENGDELKS | STGSAPILVV | MVILLNIGVA | ILFINFFI

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

String:

STRING:

9606.ENSP00000284262

KEGG:

MIM:

Pfam:

UniGene:

Uniprot:

FOR

ELISA Kit for Human JP-3

ELISA Kit for Human JP-3

CLIA Kit for Human JP-3

CLIA Kit for Human JP-3

Polyclonal Antibody for Human JP-3

Polyclonal Antibody for Human JP-3

Monoclonal Antibody for Human JP-3

Monoclonal Antibody for Human JP-3

Protein for Human JP-3

Protein for Human JP-3

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Characterization of human junctophilin subtype genes."
Nishi M. , Mizushima A. , Nakagawara K. , Takeshima H.
Biochem. Biophys. Res. Commun.273:920-927(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Brain.
2.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS THR-376; THR-472 AND LEU-645
tissue: Brain.
4.

"A repeat expansion in the gene encoding junctophilin-3 is associated with Huntington disease-like 2."
Holmes S.E. , O'Hearn E. , Rosenblatt A. , Callahan C. , Hwang H.S. , Ingersoll-Ashworth R.G. , Fleisher A. , Stevanin G. , Brice A. , Potter N.T. , Ross C.A. , Margolis R.L.
Nat. Genet.29:377-378(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-127;IDENTIFICATION (ISOFORM 2);POLYMORPHISM OF POLY-ALA REGION (ISOFORM 2)
5.

"CAG/CTG repeat expansions at the Huntington's disease-like 2 locus are rare in Huntington's disease patients."
Stevanin G. , Camuzat A. , Holmes S.E. , Julien C. , Sahloul R. , Dode C. , Hahn-Barma V. , Ross C.A. , Margolis R.L. , Durr A. , Brice A.
Neurology58:965-967(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HDL2
6.

"Huntington's disease-like 2 can present as chorea-acanthocytosis."
Walker R.H. , Rasmussen A. , Rudnicki D. , Holmes S.E. , Alonso E. , Matsuura T. , Ashizawa T. , Davidoff-Feldman B. , Margolis R.L.
Neurology61:1002-1004(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HDL2

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